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Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis

Liver cancer, predominantly hepatocellular carcinoma (HCC), represents a complex and fatal malignancy driven primarily by oxidative stress and inflammation. Due to dismal prognosis and limited therapeutic intervention, chemoprevention has emerged as…

Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis

Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway.

Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.

Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a…

Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.

Breast cancer is the second leading cause of cancer-related death in women in the United States and discovery and development of safe chemopreventive drugs is urgently needed. The fruit pomegranate (Punica granatum) is gaining importance because of…

Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.

OBJECTIVE: Osteoarthritis (OA) is characterized by cartilage degradation in the affected joints. Pomegranate fruit extract (PFE) inhibits cartilage degradation in vitro. The aim of this study was to determine whether oral consumption of PFE inhibits…

Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.

Pomegranate fruit extract (PE) rich in polyphenols has been shown to exert chondroprotective effects, but the mechanism is not established. Here, we used an in vitro model of inflammation in osteoarthritis (OA) to investigate the potential of PE to…

Tags: 2017, Ashruf Omer S, Chondrocytes, Chondrocytes – Drug Effects, Chondrocytes/drug effects, Department of Anatomy & Neurobiology, Fruit, Fruit/chemistry, Gene Expression Regulation/drug effects, Genes – Drug Effects, Haqqi Tariq M, Haseeb Abdul, Humans, I-kappa B Kinase/genetics/*metabolism, IkappaB, IKKbeta, IL-1beta, Interleukin 1 – Metabolism, Interleukin-1beta/metabolism, Interleukin-6/genetics/*metabolism, Interleukins, Interleukins – Metabolism, Khan Nazir M, NEOMED College of Medicine, NF-kappa B, NF-kappa B – Metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, NIK, Osteoarthritis, Phosphorylation – Drug Effects, Phosphorylation/drug effects, Phytotherapy research : PTR, Plant Extracts, Plant Extracts – Pharmacodynamics, Plant Extracts/chemistry/*pharmacology, Polyphenols – Pharmacodynamics, Polyphenols/pharmacology, Pomegranate, Protein-Serine-Threonine Kinases/genetics/*metabolism, Proteins – Metabolism, Punicaceae/*chemistry, Signal Transduction – Drug Effects, Signal Transduction/drug effects, Transcription Factor RelA/metabolism, Transferases, Transferases – Metabolism

Browse Items (7 total)

Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis

Pomegranate Phytoconstituents Blunt The Inflammatory Cascade In A Chemically Induced Rodent Model Of Hepatocellular Carcinogenesis

Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway.

Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.

Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis.

Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.

A Polyphenol-rich Pomegranate Fruit Extract Suppresses NF-kappaB and IL-6 Expression by Blocking the Activation of IKKbeta and NIK in Primary Human Chondrocytes.