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<a href="http://doi.org/10.1016/j.bbi.2012.08.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bbi.2012.08.001</a>
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Pages
1249-1255
Issue
8
Volume
26
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Title
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Repeated stressor exposure regionally enhances beta-adrenergic receptor-mediated brain IL-1 beta production
Publisher
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Brain Behavior and Immunity
Date
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2012
2012-11
Subject
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Anhedonia; antidepressant treatments; Chronic mild stress; chronic psychosocial stress; Cytokine; depression; depressive-like behavior; hippocampal neurogenesis; Immunology; inflammatory cytokines; ligand-binding; messenger-rna; Neurosciences & Neurology; Norepinephrine; paraventricular nucleus; prefrontal cortex; Psychiatry; rat; rat-brain; Receptor binding; Sensitization
Creator
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Porterfield V M; Gabella K M; Simmons M A; Johnson J D
Description
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It has been proposed that increased brain cytokines during repeated stressor exposure can contribute to neuropathological changes that lead to the onset of depression. Previous studies demonstrate that norepinephrine acting via beta-adrenergic receptors (beta-ARs) mediate brain IL-1 production during acute stressor exposure. The aim of the current studies was to examine how the regulation of brain cytokines by adrenergic signaling might change following repeated stressor exposure. Fischer rats were exposed to four days of chronic mild stress and 24 h after the last stressors beta-AR expression, norepinephrine turnover, and beta-AR-mediated induction of brain IL-1 were measured in limbic areas (e.g. hypothalamus, hippocampus, amygdala, and prefrontal cortex) and brainstem. Repeated stressor exposure resulted in decreases in beta-AR expression (B-max) measured by saturation binding curves in many limbic brain areas, while an increase was observed in the brainstem. This coincided with significant increases in norepinephrine turnover in the prefrontal cortex, hypothalamus, and amygdala, a significant increase in norepinephrine turnover was not observed in the hippocampus or brainstem. Stress increased overall IL-1 production in the amygdala (both basal and stimulated). While stress did not affect basal IL-1 levels in any other brain area, central administration of isoproterenol (a beta-AR agonist) augmented IL-1 production in the hypothalamus of stressed animals. These data indicate that repeated stressor exposure results in brain area specific enhancements in beta-AR-mediated IL-1 production and extends current knowledge of stress-induced enhancement of brain cytokine beyond sensitized response to immunological stimuli. (C) 2012 Elsevier Inc. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.bbi.2012.08.001" target="_blank" rel="noreferrer noopener">10.1016/j.bbi.2012.08.001</a>
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Journal Article
2012
Anhedonia
antidepressant treatments
Brain Behavior and Immunity
Chronic mild stress
chronic psychosocial stress
Cytokine
Depression
depressive-like behavior
Gabella K M
hippocampal neurogenesis
Immunology
inflammatory cytokines
Johnson J D
Journal Article
ligand-binding
messenger-rna
Neurosciences & Neurology
Norepinephrine
paraventricular nucleus
Porterfield V M
prefrontal cortex
Psychiatry
rat
rat-brain
Receptor binding
Sensitization
Simmons M A