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Text
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URL Address
<a href="http://doi.org/10.1016/j.jmig.2007.05.014" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jmig.2007.05.014</a>
Pages
633–637
Issue
5
Volume
14
Dublin Core
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Title
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Phase I/II prospective trial of autologous platelet tissue graft in gynecologic surgery.
Publisher
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Journal of minimally invasive gynecology
Date
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2007
2007-10
Subject
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80 and over; Adult; Aged; Autologous/*adverse effects/methods; Case-Control Studies; Female; Gynecologic Surgical Procedures/adverse effects/*methods; Humans; Middle Aged; Pain; Pain Measurement; Platelet-Rich Plasma/*physiology; Postoperative/*therapy; Transplantation
Creator
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Fanning James; Murrain Luis; Flora Robert; Hutchings Timothy; Johnson Jil M; Fenton Bradford W
Description
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STUDY OBJECTIVE: To perform the original phase I/II trial of autologous platelet tissue graft in gynecologic surgery to evaluate toxicity and efficacy on decreasing pain. DESIGN: Prospective nonrandomized trial (Canadian Task Force classification II-A). SETTING: Teaching hospital. PATIENTS: Fifty-five consecutive patients undergoing major gynecologic surgery were entered into this prospective phase I/II trial and were matched with 55 patients from the previous 6 months. INTERVENTION: After anesthesia was induced, peripheral venous blood (55 mL) was obtained from the patient producing, autologous platelet tissue graft (20 mL). At completion of surgery, autologous platelet tissue graft was directly applied to the surgical site. MEASUREMENTS AND MAIN RESULTS: Median pain on the day of surgery was 2.7 (mild) in the autologous platelet tissue graft group vs 6.7 (severe) in the control group, p \textless.001. Likewise, pain on postoperative day 1 was 2.1 (mild) in the autologous platelet tissue graft group vs 5.5 (moderate) in the control group, p \textless or =.001. Median of morphine per hospital stay for the autologous platelet tissue graft group was 17 mg (range 1-98 mg) vs 26 mg (range
Identifier
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<a href="http://doi.org/10.1016/j.jmig.2007.05.014" target="_blank" rel="noreferrer noopener">10.1016/j.jmig.2007.05.014</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
80 and over
Adult
Aged
Autologous/*adverse effects/methods
Case-Control Studies
Fanning James
Female
Fenton Bradford W
Flora Robert
Gynecologic Surgical Procedures/adverse effects/*methods
Humans
Hutchings Timothy
Johnson Jil M
Journal of minimally invasive gynecology
Middle Aged
Murrain Luis
Pain
Pain Measurement
Platelet-Rich Plasma/*physiology
Postoperative/*therapy
Transplantation