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Text
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URL Address
<a href="http://doi.org/10.1097/00003086-199605000-00010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/00003086-199605000-00010</a>
Pages
80–85
Issue
326
Dublin Core
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Title
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Immune response to nonspecific and altered tissue antigens in soft tissue allografts.
Publisher
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Clinical orthopaedics and related research
Date
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1996
1996-05
Subject
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Anti-Infective Agents; Articular/immunology/physiology/*transplantation; Biomechanical Phenomena; Bone Transplantation/*immunology; Cells; Cultured; Ethanol/pharmacology; Fibroblasts/drug effects; Homologous; Humans; Hydrogen Peroxide/pharmacology; Ligaments; Local/pharmacology; Povidone-Iodine/pharmacology; Therapeutic Irrigation; Tissue Preservation; Transplantation
Creator
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Pinkowski J L; Rodrigo J J; Sharkey N A; Vasseur P B
Description
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Soft tissue allografts have many uses in orthopaedic surgery, including knee ligament reconstruction, hand tendon surgery, shoulder instability, and rotator cuff reconstruction. The predictable biologic incorporation of soft tissue allografts without rejection or fear of disease transmission continues to be a goal of basic science researchers. A review of the current knowledge if the immune system response to donor specific, nonspecific, and altered tissue antigens in soft tissue or tendon allografts is presented. An in vitro study was done in an attempt to decrease immunogenicity of a frozen bone-ligament graft by adding irrigation with Betadine scrub solution and hydrogen peroxide to the conventional storage process of freezing. Although the irrigation with cytotoxic agents would undoubtedly further decrease immunogenicity, it also decreased stiffness and maximum load by 15%. Whether this decreased strength and stiffness would compromise the incorporation and long term success of soft tissue allografts would need to be studied by in vitro experiments.
Identifier
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<a href="http://doi.org/10.1097/00003086-199605000-00010" target="_blank" rel="noreferrer noopener">10.1097/00003086-199605000-00010</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Anti-Infective Agents
Articular/immunology/physiology/*transplantation
Biomechanical Phenomena
Bone Transplantation/*immunology
Cells
Clinical orthopaedics and related research
Cultured
Ethanol/pharmacology
Fibroblasts/drug effects
Homologous
Humans
Hydrogen Peroxide/pharmacology
Ligaments
Local/pharmacology
Pinkowski J L
Povidone-Iodine/pharmacology
Rodrigo J J
Sharkey N A
Therapeutic Irrigation
Tissue Preservation
Transplantation
Vasseur P B