1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2013.01.061" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2013.01.061</a>
Pages
170–183
Volume
237
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Analysis of excitatory synapses in the guinea pig inferior colliculus: a study using electron microscopy and GABA immunocytochemistry.
Publisher
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Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
*Inferior Colliculi/cytology/metabolism/ultrastructure; *Microscopy; Animals; Female; gamma-Aminobutyric Acid/*metabolism; Guinea Pigs; Immunoelectron; Male; NADPH Dehydrogenase/metabolism; Neurons/metabolism/*ultrastructure; Presynaptic Terminals/metabolism/ultrastructure; Synapses/*physiology/*ultrastructure
Creator
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Nakamoto K T; Mellott J G; Killius J; Storey-Workley M E; Sowick C S; Schofield B R
Description
An account of the resource
The inferior colliculus (IC) integrates ascending auditory input from the lower brainstem and descending input from the auditory cortex. Understanding how IC cells integrate these inputs requires identification of their synaptic arrangements. We describe excitatory synapses in the dorsal cortex, central nucleus, and lateral cortex of the IC (ICd, ICc and IClc) in guinea pigs. We used electron microscopy (EM) and post-embedding anti-GABA immunogold histochemistry on aldehyde-fixed tissue from pigmented adult guinea pigs. Excitatory synapses were identified by round vesicles, asymmetric synaptic junctions, and gamma-aminobutyric acid-immunonegative (GABA-negative) presynaptic boutons. Excitatory synapses constitute approximately 60% of the synapses in each IC subdivision. Three types can be distinguished by presynaptic profile area and number of mitochondrial profiles. Large excitatory (LE) boutons are more than 2 mum(2) in area and usually contain five or more mitochondrial profiles. Small excitatory (SE) boutons are usually less than 0.7 mum(2) in area and usually contain 0 or 1 mitochondria. Medium excitatory (ME) boutons are intermediate in size and usually contain 2 to 4 mitochondria. LE boutons are mostly confined to the ICc, while the other two types are present throughout the IC. Dendritic spines are the most common target of excitatory boutons in the IC dorsal cortex, whereas dendritic shafts are the most common target in other IC subdivisions. Finally, each bouton type terminates on both gamma-aminobutyric acid-immunopositive (GABA+) and GABA-negative (i.e., glutamatergic) targets, with terminations on GABA-negative profiles being much more frequent. The ultrastructural differences between the three types of boutons presumably reflect different origins and may indicate differences in postsynaptic effect. Despite such differences in origins, each of the bouton types contact both GABAergic and non-GABAergic IC cells, and could be expected to activate both excitatory and inhibitory IC circuits.
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<a href="http://doi.org/10.1016/j.neuroscience.2013.01.061" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2013.01.061</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Inferior Colliculi/cytology/metabolism/ultrastructure
*Microscopy
2013
Animals
Department of Anatomy & Neurobiology
Female
gamma-Aminobutyric Acid/*metabolism
Guinea Pigs
Immunoelectron
Killius J
Male
Mellott J G
NADPH Dehydrogenase/metabolism
Nakamoto K T
NEOMED College of Medicine
Neurons/metabolism/*ultrastructure
Neuroscience
Presynaptic Terminals/metabolism/ultrastructure
Schofield B R
Sowick C S
Storey-Workley M E
Synapses/*physiology/*ultrastructure
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/jnr.10033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.10033</a>
Pages
1217–1225
Issue
6
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Distribution and origin of corticotropin-releasing factor-immunoreactive axons in the female rat lumbosacral spinal cord.
Publisher
An entity responsible for making the resource available
Journal of neuroscience research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-12
Subject
The topic of the resource
Animals; Axons/*metabolism/ultrastructure; Brain/cytology/*metabolism; Corticotropin-Releasing Hormone/*metabolism; Efferent Pathways/cytology/*metabolism; Female; Fluorescent Dyes; Herpesvirus 1; Immunohistochemistry; Lumbar Vertebrae; NADPH Dehydrogenase/metabolism; Nitrergic Neurons/cytology/metabolism; Parasympathetic Nervous System/cytology/*metabolism; Paraventricular Hypothalamic Nucleus/cytology/metabolism; Pons/cytology/metabolism; Pregnancy; Presynaptic Terminals/metabolism/ultrastructure; Rats; Reproduction/physiology; Sacrum; Spinal Cord/cytology/*metabolism; Sprague-Dawley; Suid; Uterus/*innervation
Creator
An entity primarily responsible for making the resource
Puder B A; Papka R E
Description
An account of the resource
Corticotropin-releasing factor (CRF) is a neuropeptide traditionally known for its hormonal role in the hypothalamic/pituitary/adrenal stress axis. However, CRF has been reported in axons in sites that may be considered outside of the direct stress axis, e.g., in axons in the lumbosacral spinal cord associated with the micturition response. Whether any of these CRF-immunoreactive axons interacts with uterine-related preganglionic autonomic neurons or projection neurons in the lumbosacral spinal cord is unknown. Thus, immunohistochemistry and retrograde tracing were employed to determine the presence, distribution, and origin of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/jnr.10033" target="_blank" rel="noreferrer noopener">10.1002/jnr.10033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Animals
Axons/*metabolism/ultrastructure
Brain/cytology/*metabolism
Corticotropin-Releasing Hormone/*metabolism
Efferent Pathways/cytology/*metabolism
Female
Fluorescent Dyes
Herpesvirus 1
Immunohistochemistry
Journal of neuroscience research
Lumbar Vertebrae
NADPH Dehydrogenase/metabolism
Nitrergic Neurons/cytology/metabolism
Papka R E
Parasympathetic Nervous System/cytology/*metabolism
Paraventricular Hypothalamic Nucleus/cytology/metabolism
Pons/cytology/metabolism
Pregnancy
Presynaptic Terminals/metabolism/ultrastructure
Puder B A
Rats
Reproduction/physiology
Sacrum
Spinal Cord/cytology/*metabolism
Sprague-Dawley
Suid
Uterus/*innervation