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Text
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<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0303-7207(94)90168-6</a>
Pages
183–191
Issue
2
Volume
105
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Title
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Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Publisher
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Molecular and cellular endocrinology
Date
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1994
1994-11
Subject
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5-Hydroxytryptophan/pharmacology; alpha-Methyltyrosine; Animals; Anterior/*chemistry/drug effects/metabolism; Blotting; Bromocriptine/pharmacology; Gene Expression Regulation/drug effects/physiology; Genetic; Haloperidol/pharmacology; Ketanserin/pharmacology; Male; Messenger/*analysis/genetics; Methiothepin/pharmacology; Methoxydimethyltryptamines/pharmacology; Methyltyrosines/pharmacology; Northern; Pituitary Gland; Prolactin/analysis/*genetics/metabolism; Quipazine/pharmacology; Rats; RNA; Serotonin/*physiology; Sprague-Dawley; Time Factors; Transcription; Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Creator
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Signs S A; Liu B; Wolford J; Carrillo A J
Description
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These studies examined the contribution of serotonin (5-HT) to the control of prolactin (PRL) and vasoactive intestinal peptide (VIP) messenger RNA expression in rat anterior pituitary. Daily injection of rats with the biosynthetic precursor to serotonin, 5-hydroxytryptophan (5-HTP; 25 mg/kg, q.i.d.), resulted on day 5 in a 50% increase in the expression of PRL mRNA in the pituitary while at the same time reducing the levels of both the 1.0 and 1.7 kb VIP mRNA transcripts. Co-treatment of rats with 5-HTP plus the catecholamine biosynthesis inhibitor, alpha-methyl-tyrosine (alpha-MT; 150 mg/kg, q.d. x 2 days), or the dopamine receptor antagonist haloperidol (1.25 mg/kg, b.i.d. x 5 days), resulted in increases in pituitary PRL message levels that were greater than those observed with either anti-dopaminergic agent alone. In contrast, 5-HTP was unable to reverse the inhibition of PRL mRNA expression caused by treatment with the dopamine receptor agonist bromocriptine (2.5 mg/kg, b.i.d. x 5 days). Neither alpha-MT, haloperidol nor bromocriptine had a significant effect on pituitary VIP mRNA expression. Administration of the direct-acting 5-HT receptor agonist quipazine (5 mg/kg, b.i.d.) for 14 consecutive days caused a significant increase in pituitary PRL mRNA levels on day 1 and reached a plateau of 90% above control levels on days 7 and 14. VIP mRNA levels rose significantly on day 1 of quipazine treatment but thereafter fell to a minimum of 22% (1.0 kb) and 52% (1.7 kb) of control by day 14.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
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<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">10.1016/0303-7207(94)90168-6</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5-Hydroxytryptophan/pharmacology
alpha-Methyltyrosine
Animals
Anterior/*chemistry/drug effects/metabolism
Blotting
Bromocriptine/pharmacology
Carrillo A J
Gene Expression Regulation/drug effects/physiology
Genetic
Haloperidol/pharmacology
Ketanserin/pharmacology
Liu B
Male
Messenger/*analysis/genetics
Methiothepin/pharmacology
Methoxydimethyltryptamines/pharmacology
Methyltyrosines/pharmacology
Molecular and cellular endocrinology
Northern
Pituitary Gland
Prolactin/analysis/*genetics/metabolism
Quipazine/pharmacology
Rats
RNA
Serotonin/*physiology
Signs S A
Sprague-Dawley
Time Factors
Transcription
Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Wolford J