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Text
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<a href="http://doi.org/10.1097/RUQ.0b013e318249f594" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/RUQ.0b013e318249f594</a>
Pages
13–20
Issue
1
Volume
28
Dublin Core
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Title
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Shear wave ultrasound elastography of the prostate: initial results.
Publisher
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Ultrasound quarterly
Date
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2012
2012-03
Subject
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*Endosonography; Aged; Biopsy; Biopsy – Methods; Diagnosis; Differential; Elasticity; Elasticity Imaging Techniques/*methods; Equipment and Supplies; Follow-Up Studies; Health Screening; Human; Humans; Magnetic Resonance Imaging; Male; Middle Age; Middle Aged; Ohio; Predictive Value of Tests; Prospective Studies; Prostate – Analysis; Prostate – Anatomy and Histology; Prostate-Specific Antigen – Blood; Prostate/*diagnostic imaging/pathology; Prostatic Hypertrophy; Prostatic Neoplasms – Diagnosis; Prostatic Neoplasms – Pathology; Prostatic Neoplasms/*diagnostic imaging/pathology; Rectum; ROC Curve; Sensitivity and Specificity; Spectrum Analysis; Ultrasonography – Methods
Creator
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Barr Richard G; Memo Richard; Schaub Carl R
Description
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PURPOSE: This prospective study was to evaluate shear wave elastography (SWE) in the detection of prostate cancer (PC). METHODS: Patients scheduled for a transrectal ultrasound (TRUS) biopsy of the prostate because of elevated prostate-specific antigen levels or abnormal digital rectal examination result underwent a standard TRUS and SWE. A second TRUS examination and sextant biopsy by a second physician blinded to SWE results was then performed. Pathologic result was reviewed, and sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were calculated. RESULTS: A total of 53 patients (318 sextants) participated in the study. Mean age was 64.2 years (range, 53-79 years). A total of 26 foci of PC were detected in 11 patients (20.7%). On the basis of the receiver operating characteristic curve, a value of 37 kPa was used as the cutoff between benign and malignant. This produced a sensitivity of 96.2% (25/26), a specificity of 96.2% (281/292), a PPV of 69.4% (25/36), and an NPV of 99.6% (281/282). Six (55%) of 11 false-positive samples were secondary to benign calcifications. The Young modulus of PC ranged from 30 to 110 kPa (mean [SD], 58.0 [20.7] kPa). At the patient level, if a cutoff of 40 kPa was used, all PCs would have been detected, and the positive biopsy rate would be 11 (50%) of 22 compared to 11 (20.8%) of 53 without SWE–a 140% increase in the positive biopsy rate. CONCLUSIONS: Shear wave elastography has a high sensitivity, specificity, PPV, and NPV for the detection of PC. With a high PPV, patients with elevated prostate-specific antigen levels or abnormal results in the digital rectal examination and negative SWE may not require biopsy. This could significantly reduce the negative biopsy rate in PC detection.
Identifier
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<a href="http://doi.org/10.1097/RUQ.0b013e318249f594" target="_blank" rel="noreferrer noopener">10.1097/RUQ.0b013e318249f594</a>
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*Endosonography
2012
Aged
Barr Richard G
Biopsy
Biopsy – Methods
Diagnosis
Differential
Elasticity
Elasticity Imaging Techniques/*methods
Equipment and Supplies
Follow-Up Studies
Health Screening
Human
Humans
Magnetic Resonance Imaging
Male
Memo Richard
Middle Age
Middle Aged
Ohio
Predictive Value of Tests
Prospective Studies
Prostate – Analysis
Prostate – Anatomy and Histology
Prostate-Specific Antigen – Blood
Prostate/*diagnostic imaging/pathology
Prostatic Hypertrophy
Prostatic Neoplasms – Diagnosis
Prostatic Neoplasms – Pathology
Prostatic Neoplasms/*diagnostic imaging/pathology
Rectum
ROC Curve
Schaub Carl R
Sensitivity and Specificity
Spectrum Analysis
Ultrasonography – Methods
Ultrasound quarterly