1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/exer.1996.0033</a>
Pages
271–283
Issue
3
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spatial and temporal variations in extracellular matrix of periocular and corneal regions during corneal stromal development.
Publisher
An entity responsible for making the resource available
Experimental eye research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-03
Subject
The topic of the resource
*Extracellular Matrix; Animals; Cell Differentiation; Chick Embryo; Collagen/biosynthesis; Cornea/chemistry/*embryology/metabolism; Eye Proteins/analysis; Fibroblasts/cytology; Glycoproteins/analysis; Neural Crest/cytology; Proteoglycans/biosynthesis; Time Factors
Creator
An entity primarily responsible for making the resource
Doane K J; Ting W H; McLaughlin J S; Birk D E
Description
An account of the resource
The development of the avian corneal stroma occurs in discrete developmental stages. During this sequence of events, the neural crest-derived corneal fibroblast precursor cells are surrounded by distinct extracellular matrices which change both spatially and temporally. To elucidate the role of these matrices, extracellular matrix components in the periocular mesenchyme and cornea were analysed prior to and during migration and differentiation of corneal fibroblasts using antibodies against collagens, proteoglycans and glycoproteins. Previous work has concentrated on the matrix of the corneal stroma rather than the matrix of the periocular mesenchyme. Since the precursors of the corneal fibroblasts are present within the must migrate through the periocular mesenchyme prior to entry into the cornea proper, this environment was fully evaluated. The present study documents the matrix composition of both the cornea and periocular mesenchyme at developmental stages that are prior to and after initiation of corneal invasion by the corneal fibroblast precursors. Variations in matrix molecules comprising both the periocular mesenchyme and cornea were demonstrated. These include changes in the distribution of collagen types I, II, III, IV and VI; the proteoglycans decorin and lumican; as well as the adhesive glycoproteins tenascin, fibronectin and laminin. It is hypothesized that the variations in matrix localization are important in the regulation of cell migration and differentiation during normal corneal development. Any regulation is likely to involve a combination of components found in the extracellular matrices and therefore, a consideration of the matrix rather than isolated components is required.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/exer.1996.0033" target="_blank" rel="noreferrer noopener">10.1006/exer.1996.0033</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Extracellular Matrix
1996
Animals
Birk D E
Cell Differentiation
Chick Embryo
Collagen/biosynthesis
Cornea/chemistry/*embryology/metabolism
Doane K J
Experimental eye research
Eye Proteins/analysis
Fibroblasts/cytology
Glycoproteins/analysis
McLaughlin J S
Neural Crest/cytology
Proteoglycans/biosynthesis
Time Factors
Ting W H
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajpheart.00653.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.00653.2016</a>
Pages
H541–H545
Issue
3
Volume
312
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The JCR:LA-cp rat: a novel rodent model of cystic medial necrosis.
Publisher
An entity responsible for making the resource available
American journal of physiology. Heart and circulatory physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-03
Subject
The topic of the resource
*Rats; Animal; Animals; Aortic Aneurysm; Atherosclerosis/pathology; Blood Glucose/metabolism; Blood Vessels/pathology; Body Weight; Collagen/biosynthesis; Cysts/*genetics/pathology; Disease Models; hypoxia; Hypoxia; Inbred Strains; leptin; Lipids/blood; Male; metabolic syndrome; Metabolic Syndrome/*genetics/pathology; Necrosis; Proteoglycans/biosynthesis; Rats; rodent model; Thoracic/*genetics/pathology
Creator
An entity primarily responsible for making the resource
Pung Yuh Fen; Chilian William M; Bennett Martin R; Figg Nichola; Kamarulzaman Mohd Hamzah
Description
An account of the resource
Although there are multiple rodent models of the metabolic syndrome, very few develop vascular complications. In contrast, the JCR:LA-cp rat develops both metabolic syndrome and early atherosclerosis in predisposed areas. However, the pathology of the normal vessel wall has not been described. We examined JCR:LA control (+/+) or cp/cp rats fed normal chow diet for 6 or 18 mo. JCR:LA-cp rats developed multiple features of advanced cystic medial necrosis including "cysts," increased collagen formation and proteoglycan deposition around cysts, apoptosis of vascular smooth muscle cells, and spotty medial calcification. These appearances began within 6 mo and were extensive by 18 mo. JCR:LA-cp rats had reduced medial cellularity, increased medial thickness, and vessel hypoxia that was most marked in the adventitia. In conclusion, the normal chow-fed JCR:LA-cp rat represents a novel rodent model of cystic medial necrosis, associated with multiple metabolic abnormalities, vascular smooth muscle cell apoptosis, and vessel hypoxia.NEW & NOTEWORTHY Triggers for cystic medial necrosis (CMN) have been difficult to study due to lack of animal models to recapitulate the pathologies seen in humans. Our study is the first description of CMN in the rat. Thus the JCR:LA-cp rat represents a useful model to investigate the underlying molecular changes leading to the development of CMN.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajpheart.00653.2016" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.00653.2016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Rats
2017
American journal of physiology. Heart and circulatory physiology
Animal
Animals
Aortic Aneurysm
Atherosclerosis/pathology
Bennett Martin R
Blood Glucose/metabolism
Blood Vessels/pathology
Body Weight
Chilian William M
Collagen/biosynthesis
Cysts/*genetics/pathology
Department of Integrative Medical Sciences
Disease Models
Figg Nichola
hypoxia
Inbred Strains
Kamarulzaman Mohd Hamzah
leptin
Lipids/blood
Male
Metabolic syndrome
Metabolic Syndrome/*genetics/pathology
Necrosis
NEOMED College of Medicine
Proteoglycans/biosynthesis
Pung Yuh Fen
Rats
rodent model
Thoracic/*genetics/pathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1369/jhc.2009.953893" target="_blank" rel="noreferrer noopener">http://doi.org/10.1369/jhc.2009.953893</a>
Pages
923–931
Issue
10
Volume
57
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Publisher
An entity responsible for making the resource available
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-10
Subject
The topic of the resource
Adult; Humans; Middle Aged; Osteoarthritis; Biomarkers/metabolism; Proteoglycans/biosynthesis; Down-Regulation; Up-Regulation; Cartilage; Antigens/biosynthesis; Bone Neoplasms/metabolism; Chondrosarcoma/metabolism; Collagen Type VI/*biosynthesis; DNA-Binding Proteins/*biosynthesis; Endoplasmic Reticulum/*metabolism; Heat-Shock Proteins/*biosynthesis; Osteosarcoma/metabolism; Transcription Factors/*biosynthesis; Articular/metabolism; Knee/*metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Nugent Ashleigh E; Speicher Danielle M; Gradisar Ian; McBurney Denise L; Baraga Anthony; Doane Kathleen J; Horton Walter E Jr
Description
An account of the resource
To test the hypothesis that a perturbation of endoplasmic reticulum (ER) function is involved in the pathogenesis of osteoarthritis (OA), articular cartilage was isolated from non-OA patients secondary to resection of osteo- or chondrosarcomas. Intra-joint samples of minimal and advanced osteoarthritic cartilage were isolated from patients undergoing total knee arthroplasty and scored for disease severity. Glucose-regulated protein-78 (grp78) and bcl-2-associated athanogene-1 (bag-1) were detected via immunofluorescence as markers of non-homeostatic ER function. Additionally, the expression of type VI collagen and its integrin receptor, NG2, was determined to examine cartilage matrix health and turnover. There was an upregulation of grp78 in advanced OA, and variable expression in minimal OA. Non-OA cartilage was consistently grp78 negative. The downstream regulator bag-1 was also upregulated in OA compared with normal cartilage. Collagen VI was mainly cell-associated in non-OA cartilage, with a more widespread distribution observed in OA cartilage along with increased intracellular staining intensity. The collagen VI integral membrane proteoglycan receptor NG2 was downregulated in advanced OA compared with its patient-matched minimally involved cartilage sample. These results suggest that chondrocytes exhibit ER stress during OA, in association with upregulation of a large secreted molecule, type VI collagen.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1369/jhc.2009.953893" target="_blank" rel="noreferrer noopener">10.1369/jhc.2009.953893</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Adult
Antigens/biosynthesis
Articular/metabolism
Baraga Anthony
Biomarkers/metabolism
Bone Neoplasms/metabolism
Cartilage
Chondrosarcoma/metabolism
Collagen Type VI/*biosynthesis
Department of Anatomy & Neurobiology
DNA-Binding Proteins/*biosynthesis
Doane Kathleen J
Down-Regulation
Endoplasmic Reticulum/*metabolism
Gradisar Ian
Heat-Shock Proteins/*biosynthesis
Horton Walter E Jr
Humans
Knee/*metabolism/physiopathology
McBurney Denise L
Middle Aged
NEOMED College of Medicine
Nugent Ashleigh E
Osteoarthritis
Osteosarcoma/metabolism
Proteoglycans/biosynthesis
Speicher Danielle M
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Transcription Factors/*biosynthesis
Up-Regulation