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Text
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URL Address
<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jnutbio.2010.09.001</a>
Pages
1035–1046
Issue
11
Volume
22
Dublin Core
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Title
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Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.
Publisher
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The Journal of nutritional biochemistry
Date
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2011
2011-11
Subject
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Animals; Anthocyanins/*therapeutic use; Anticarcinogenic Agents/therapeutic use; Apoptosis/drug effects; bcl-2-Associated X Protein/metabolism; Cell Proliferation/drug effects; Chemoprevention; Diethylnitrosamine; Down-Regulation; Experimental/metabolism/pathology; Liver Neoplasms; Liver Neoplasms/chemically induced/*prevention & control; Liver/pathology; Male; Phenobarbital; Plant Extracts/*therapeutic use; Proliferating Cell Nuclear Antigen/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; Ribes/chemistry; Sprague-Dawley; Up-Regulation
Creator
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Bishayee Anupam; Mbimba Thomas; Thoppil Roslin J; Haznagy-Radnai Erzsebet; Sipos Peter; Darvesh Altaf S; Folkesson Hans G; Hohmann Judit
Description
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Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This "superfruit" is known to possess various pharmacological effects including alleviation of chronic oxidative stress and inflammation. In contrast to a large volume of literature on the health benefits of black currant, limited evidence on antitumor effects of black currant exists with virtually no data on the prevention of experimental carcinogenesis. In the current study, we have investigated the chemopreventive effects of an anthocyanin-rich black currant skin extract (BCSE) utilizing our well-characterized model of rat liver carcinogenesis. Initiation of hepatocarcinogenesis was done by intraperitoneal injection of diethylnitrosamine (DENA) followed by promotion with phenobarbital. The rats were exposed to dietary BCSE for 4 weeks prior to initiation, and the treatment was continued for 22 consecutive weeks. BCSE dose-dependently decreased the incidence, total number, multiplicity, size and volume of preneoplastic hepatic nodules. The antihepatocarcinogenic effect of BCSE was confirmed by histopathological examination of liver sections. Immunohistochemical analysis of proliferating cell nuclear antigen and DNA fragmentation revealed BCSE-mediated inhibition of abnormal cell proliferation and induction of apoptosis in
Identifier
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<a href="http://doi.org/10.1016/j.jnutbio.2010.09.001" target="_blank" rel="noreferrer noopener">10.1016/j.jnutbio.2010.09.001</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Anthocyanins/*therapeutic use
Anticarcinogenic Agents/therapeutic use
Apoptosis/drug effects
bcl-2-Associated X Protein/metabolism
Bishayee Anupam
Cell Proliferation/drug effects
Chemoprevention
Darvesh Altaf S
Department of Pharmaceutical Sciences
Diethylnitrosamine
Down-Regulation
Experimental/metabolism/pathology
Folkesson Hans G
Haznagy-Radnai Erzsebet
Hohmann Judit
Liver Neoplasms
Liver Neoplasms/chemically induced/*prevention & control
Liver/pathology
Male
Mbimba Thomas
NEOMED College of Pharmacy
Phenobarbital
Plant Extracts/*therapeutic use
Proliferating Cell Nuclear Antigen/metabolism
Proto-Oncogene Proteins c-bcl-2/metabolism
Rats
Ribes/chemistry
Sipos Peter
Sprague-Dawley
The Journal of nutritional biochemistry
Thoppil Roslin J
Up-Regulation