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Text
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URL Address
<a href="http://doi.org/10.1002/jnr.10421" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/jnr.10421</a>
Pages
808–816
Issue
6
Volume
70
Dublin Core
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Title
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Estrogen receptor-alpha and neural circuits to the spinal cord during pregnancy.
Publisher
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Journal of neuroscience research
Date
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2002
2002-12
Subject
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Afferent/*metabolism; Animal/*physiology; Animals; Autonomic/anatomy & histology/metabolism; Blotting; Estrogen Receptor alpha; Estrogen/*biosynthesis; Estrogens/*physiology; Female; Ganglia; Immunohistochemistry; Neurons; Parturition/physiology; Pregnancy; Proto-Oncogene Proteins c-fos/*biosynthesis; Rats; Receptors; Sensory/anatomy & histology/metabolism; Spinal Cord/anatomy & histology/metabolism; Sprague-Dawley; Time Factors; Uterus/innervation; Western
Creator
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Papka R E; Hafemeister J; Puder B A; Usip S; Storey-Workley M
Description
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Estrogen receptor immunoreactivity and mRNAs are present in spinal cord neurons in locations that are associated with sensory and autonomic innervation of female reproductive organs. The present study was undertaken to examine the expression of estrogen receptor-alpha in the spinal cord during different stages of pregnancy and to determine whether estrogen receptor-alpha-expressing neurons are related to uterine afferent nerves bringing information to the spinal cord at parturition. Immunohistochemistry showed estrogen receptor-alpha-immunoreactive neurons in the dorsal one-half of the spinal cord, i.e., dorsal horn, dorsal intermediate gray areas (dorsal commissural nucleus), and around the central canal and sacral parasympathetic autonomic nucleus of the lumbosacral spinal cord. Neurons in these areas corresponded topographically to the distribution of central processes of visceral primary afferent neurons (e.g., containing calcitonin gene-related peptide and substance P) that innervate and activate second-order spinal cord neurons (evidenced by their expression of Fos) at parturition. Western blots showed that estrogen receptor-alpha increases in the spinal cord, with a peak at day 20 of gestation, followed by a slight decrease by 2 days postpartum. These studies show that estrogen receptor-alpha is expressed by neurons in autonomic and sensory areas of the lumbosacral spinal cord that have connections with the female reproductive system and that the level of estrogen receptor-alpha changes over the course of pregnancy, which may follow profiles of steroid hormones. Many of these neurons may be involved in processing information related to reproductive organ function, changes during pregnancy, and relays to other CNS centers.
Identifier
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<a href="http://doi.org/10.1002/jnr.10421" target="_blank" rel="noreferrer noopener">10.1002/jnr.10421</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Afferent/*metabolism
Animal/*physiology
Animals
Autonomic/anatomy & histology/metabolism
Blotting
Department of Anatomy & Neurobiology
Estrogen Receptor alpha
Estrogen/*biosynthesis
Estrogens/*physiology
Female
Ganglia
Hafemeister J
Immunohistochemistry
Journal of neuroscience research
NEOMED College of Medicine
Neurons
Papka R E
Parturition/physiology
Pregnancy
Proto-Oncogene Proteins c-fos/*biosynthesis
Puder B A
Rats
Receptors
Sensory/anatomy & histology/metabolism
Spinal Cord/anatomy & histology/metabolism
Sprague-Dawley
Storey-Workley M
Time Factors
Usip S
Uterus/innervation
Western