1
40
14
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00428115" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00428115</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
277-281
Issue
3
Volume
68
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
ABILITY OF 3-CARBOXYSALSOLINOL TO PRODUCE ETHANOL-LIKE DISCRIMINATION IN RATS
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1980
1980
Subject
The topic of the resource
Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
Creator
An entity primarily responsible for making the resource
Schechter M D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00428115" target="_blank" rel="noreferrer noopener">10.1007/bf00428115</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1980
Journal Article
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.biopsych.2004.06.023</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
301-307
Issue
5
Volume
56
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Dublin Core
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Title
A name given to the resource
Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria
Publisher
An entity responsible for making the resource available
Biological Psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-09
Subject
The topic of the resource
cognition; cognitive assessment; cognitive enhancement; impairment; memory; neural basis; neurocognition; neurocognitive deficits; neuroleptic-naive; neuropsychological function; Neurosciences & Neurology; performance; Psychiatry; psychopharmacology; risperidone; schizophrenia; siblings; thought-disorder
Creator
An entity primarily responsible for making the resource
Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R
Description
An account of the resource
To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) establisbed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference . The goals of the meeting were to 1) the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria, for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literatum and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory. Reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizopbrenia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">10.1016/j.biopsych.2004.06.023</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2004
Barch D M
Biological psychiatry
Cognition
cognitive assessment
cognitive enhancement
Cohen J
Essock S
Fenton W S
Frese F
Gold J M
Goldberg T E
Green M F
Heaton R K
impairment
Journal Article or Conference Abstract Publication
Keefe R S E
Kern R S
Kraemer H
Marder S R
Memory
neural basis
neurocognition
neurocognitive deficits
neuroleptic-naive
neuropsychological function
Neurosciences & Neurology
Nuechterlein K H
Performance
Psychiatry
Psychopharmacology
risperidone
Schizophrenia
siblings
Stover E
thought-disorder
Weinberger D R
Zalcman S
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S44-S44
Issue
4
Volume
89
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
COMPARISON OF NORFENFLURAMINE (NF) DISCRIMINATION IN DRUG (NF)-DRUG (AMPHETAMINE) AND DRUG (NF)-SALINE TRAINED RATS
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1986
1986
Subject
The topic of the resource
Psychiatry; Neurosciences & Neurology; Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1986
Boja J W
Journal Article or Conference Abstract Publication
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02245271" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02245271</a>
Pages
564–568
Issue
4
Volume
107
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1905-6
Subject
The topic of the resource
Animals; Avoidance Learning/*drug effects; Conditioning; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Motor Activity/drug effects; Operant/drug effects; Rats; Sleep/drug effects; Species Specificity
Creator
An entity primarily responsible for making the resource
Schechter M D; Krimmer E C
Description
An account of the resource
Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontaneous locomotor activity over a 30-min period, as well as the loss of righting reflex with a higher ethanol dose (3.0 g/kg), were determined in these animals. The LAS rats reacted more aversively to 1.0 g/kg during conditioned place aversion testing than the HAS animals and also had a shorter mean sleeping time following 3.0 g/kg ethanol. Furthermore, dose-related depression of spontaneous motor activity was seen in the HAS animals and not in the LAS animals over a 30-min period using doses of 0.3, 0.6, or 1.0 g/kg (10% w/v) ethanol. Taken together, the results indicate that the intoxicating sequelae of high ethanol doses, such as ataxia and sedation, may not be correlated with the aversive effects of low ethanol doses.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02245271" target="_blank" rel="noreferrer noopener">10.1007/bf02245271</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Animals
Avoidance Learning/*drug effects
Conditioning
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Krimmer E C
Motor Activity/drug effects
Operant/drug effects
Psychopharmacology
Rats
Schechter M D
Sleep/drug effects
Species Specificity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00427431" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00427431</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
99-103
Issue
1
Volume
83
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
DIFFERENTIAL-EFFECTS OF APOMORPHINE IN 6-HYDROXYDOPAMINE-TREATED AND AGED RATS
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1984
1984
Subject
The topic of the resource
Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
Creator
An entity primarily responsible for making the resource
Schechter M D; Concannon J T
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00427431" target="_blank" rel="noreferrer noopener">10.1007/bf00427431</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1984
Concannon J T
Journal Article
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S13-S13
Issue
1
Volume
96
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
EFFECT OF PLG ON AMPHETAMINE DRUG DISCRIMINATION IN RATS
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988
Subject
The topic of the resource
Psychiatry; Neurosciences & Neurology; Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Davy S J; Schechter M D
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1988
Davy S J
Journal Article or Conference Abstract Publication
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.7759/cureus.1772" target="_blank" rel="noreferrer noopener">http://doi.org/10.7759/cureus.1772</a>
Pages
e1772–e1772
Issue
10
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ethnic and Age Disparities in Patients Taking Long-acting Injectable Atypical Antipsychotics.
Publisher
An entity responsible for making the resource available
Cureus
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-10
Subject
The topic of the resource
antipsychotics; asian americans; duration of untreated psychosis; inpatient psychiatry; long-acting injections; psychopharmacology; racial disparities; schizophrenia
Creator
An entity primarily responsible for making the resource
Soleman Mateen; Lam Nikki; Woo Benjamin K
Description
An account of the resource
Introduction This study will determine whether different ethnicities and different age groups receive equal amounts of long-acting atypical antipsychotics in comparison to their oral equivalents. Methods Secondary analyses of data from the Los Angeles County Department of Health Services Electronic Health Record (total N=63,134 inpatient visits) were performed. Chi-squared statistics were used to compare ethnicity and age with the use of either risperidone injectable or paliperidone palmitate (r-LAIs) versus risperidone oral. Results Among the 63,134 total inpatient visits, there were 3,011 patient visits that included the use of an atypical antipsychotic. Of these 3,011 visits, 452 (15.0%) were on r-LAIs and 2,559 (85.0%) were on risperidone oral. No statistically significant disparities were identified with the use of r-LAIs as compared to oral risperidone amongst ethnic groups (chi-square = 0.88, df = 3, p = 0.831). However, there was a statistically significant difference with the use of r-LAIs as compared to oral Risperidone amongst age groups, favoring younger patients (chi-square = 13.46, df = 3, p \textless 0.004). Conclusion Our data indicate a lack of ethnic disparities in prescribing long-acting atypical antipsychotics and an increased percentage of younger patients being treated with atypical depot antipsychotics over their oral equivalents.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.7759/cureus.1772" target="_blank" rel="noreferrer noopener">10.7759/cureus.1772</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
antipsychotics
Asian Americans
Cureus
duration of untreated psychosis
inpatient psychiatry
Lam Nikki
long-acting injections
Psychopharmacology
racial disparities
Schizophrenia
Soleman Mateen
Woo Benjamin K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S57-S57
Issue
1
Volume
96
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
HPLC EVALUATION OF TET-INDUCED NEUROCHEMICAL CHANGES INVIVO - CORRELATION WITH BEHAVIORAL OBSERVATIONS
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988
Subject
The topic of the resource
Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
Creator
An entity primarily responsible for making the resource
Ting Y L T; Fountain S B; Teyler T J
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1988
Fountain S B
Journal Article
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Teyler T J
Ting Y L T
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02245925</a>
Pages
221–226
Issue
2
Volume
102
Dublin Core
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Title
A name given to the resource
Increased drug sensitivity in the drug discrimination procedure afforded by drug versus drug training.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Amphetamine/pharmacology; Discrimination Learning/*drug effects; Discrimination (Psychology)/*drug effects; Norfenfluramine/pharmacology; Reinforcement Schedule; Pentobarbital/pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Rats were trained to discriminate norfenfluramine (NF) 1.4 mg/kg from its vehicle or amphetamine (AMPH) 0.8 mg/kg or pentobarbital (PB) 6.0 mg/kg in order to determine the role that drug combination training plays in the rate of learning and sensitivity to lower drug doses. The results suggest that drug versus drug training can increase the rate of drug discrimination learning for some drugs that are learned slowly when trained in a drug versus vehicle training procedure, whereas drug versus drug training does not increase the rate of learning for other drugs that are learned rapidly. Drug versus drug training does, however, appear to increase the level of stimulus control of the training drug for all drugs examined in this study.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02245925" target="_blank" rel="noreferrer noopener">10.1007/bf02245925</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Amphetamine/pharmacology
Animals
Boja J W
Discrimination (Psychology)/*drug effects
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Inbred Strains
Male
Norfenfluramine/pharmacology
Pentobarbital/pharmacology
Psychopharmacology
Rats
Reinforcement Schedule
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf00426820" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf00426820</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
105-106
Issue
1
Volume
61
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interaction Between Discrimination Of Drug States And External Stimuli
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1979
1979
Subject
The topic of the resource
Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
Creator
An entity primarily responsible for making the resource
Duncan P M; Phillips J; Reints J; Schechter M D
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf00426820" target="_blank" rel="noreferrer noopener">10.1007/bf00426820</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1979
Duncan P M
Neurosciences & Neurology
Pharmacology & Pharmacy
Phillips J
Psychiatry
Psychopharmacology
Reints J
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S6-S6
Issue
1
Volume
96
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
IS INCREASED CUE SENSITIVITY OF THE DRUG VS DRUG DISCRIMINATION DUE TO AROUSAL OR PHARMACOLOGICAL DIFFERENCES
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988
Subject
The topic of the resource
Psychiatry; Neurosciences & Neurology; Pharmacology & Pharmacy
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1988
Boja J W
Journal Article or Conference Abstract Publication
Neurosciences & Neurology
Pharmacology & Pharmacy
Psychiatry
Psychopharmacology
Schechter M D
-
Hyperlink
A link, or reference, to another resource on the Internet.
URL
https://doi.org/10.1016/j.psc.2022.07.004
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Psychopharmacology in the Elderly: Why Does Age Matter?
Creator
An entity primarily responsible for making the resource
Kripa Balaram
Date
A point or period of time associated with an event in the lifecycle of the resource
2022
Description
An account of the resource
A growing percentage of the population is aging, with a large subset of this group meeting criteria for one or more neuropsychiatric disorders. Generally, physiological changes due to aging affect most of the pharmacokinetic processes in the body, with age-related physiologic changes in cardiovascular, gastric, hepatic, and renal function leading to changes in the pharmacokinetics of medications that can affect the absorption, distribution, accumulation, and clearance and elimination of various medications. This article aims to discuss the common pharmacodynamic and pharmacokinetic changes associated with physiologic aging and their impacts on the use of psychotropic medications in the elderly.
Source
A related resource from which the described resource is derived
Psychiatr Clin North Am
. 2022 Dec;45(4):735-744. doi: 10.1016/j.psc.2022.07.004. Epub 2022 Oct 14.
Language
A language of the resource
English
2022
Antidepressants
antipsychotics
Elderly
Metabolism
Mood stabilizers
Psychopharmacology
Psychotropics
Sedative-hypnotics.
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02253729</a>
Pages
126–131
Issue
1
Volume
101
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rats become acutely tolerant to cathine after amphetamine or cathinone administration.
Publisher
An entity responsible for making the resource available
Psychopharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1905-06
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Discrimination (Psychology)/drug effects; Psychotropic Drugs/*pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Phenylpropanolamine/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
The drug discrimination paradigm was used to evaluate in rats the ability of the discriminate response to either 0.8 mg/kg d-amphetamine or 0.8 mg/kg l-cathinone to generalize to 2.4-6.0 mg/kg of the active cathinone metabolite d-norpseudoephedrine, also known as cathine. When tested 24 h after vehicle administration, cathine generalized in a dose-related fashion in rats (n = 6) trained with cathinone (ED50 = 3.03 mg/kg) and in rats (n = 8) trained with amphetamine (ED50 = 2.93 mg/kg). In contrast, when cathine was tested 24 h after the administration of either amphetamine or cathinone, it produced significantly decreased discriminative performance. The possibility that this acute tolerance may have been produced by release, and subsequent depletion, of brain dopamine was tested by pretreating rats with the dopamine release inhibitor CGS 10746B. When CGS 10746B was administered prior to cathinone it significantly decreased cathinone discrimination. In addition, acute tolerance to cathine at 24 h after vehicle-cathinone co-administration was reversed when cathine was tested 24 h after CGS 10746B-cathinone co-administration. The results suggest that cathinone-produced discriminative stimulus, as well as the acute tolerance to cathine, may be dopaminergically mediated.
Identifier
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<a href="http://doi.org/10.1007/bf02253729" target="_blank" rel="noreferrer noopener">10.1007/bf02253729</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Discrimination (Psychology)/drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Inbred Strains
Male
Phenylpropanolamine/*pharmacology
Psychopharmacology
Psychotropic Drugs/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
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URL Address
<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf02246057</a>
Pages
79–84
Issue
1
Volume
119
Dublin Core
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Title
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The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.
Publisher
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Psychopharmacology
Date
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1995
1995-05
Subject
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Amphetamine/pharmacology; Animals; Apomorphine/pharmacology; Benzazepines/pharmacology; Cocaine/pharmacology; Discrimination (Psychology); Dopamine Agonists/pharmacology; Dopamine D1/*agonists; Dose-Response Relationship; Drug; Male; Phenanthridines/*pharmacology; Rats; Receptors; Sprague-Dawley
Creator
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Schechter M D
Description
An account of the resource
The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist dihydrexidine (DHX) within 20 sessions using a training dose of 3.0 mg/kg. DHX (0.75-4.5 mg/kg) dose-dependently increased DHX-appropriate responding with an ED50 = 1.44 mg/kg. The selective D1 agonist SKF 38398 (2.0-8.0 mg/kg) dose-responsively generalized with an ED50 = 3.54 mg/kg; significantly less potent than DHX. The selective D1 antagonist SCH 23390 (0.06-0.12 mg/kg) dose-responsively decreased DHX-appropriate discriminative performance. These data would indicate that DHX is a selective D1 agonist that may allow for testing of the selectivity of other putative D1 agonists in this experimental procedure. Administration of non-selective dopaminergically active drugs, including apomorphine, amphetamine and cocaine, were each shown to produce intermediate
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf02246057" target="_blank" rel="noreferrer noopener">10.1007/bf02246057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Amphetamine/pharmacology
Animals
Apomorphine/pharmacology
Benzazepines/pharmacology
Cocaine/pharmacology
Discrimination (Psychology)
Dopamine Agonists/pharmacology
Dopamine D1/*agonists
Dose-Response Relationship
Drug
Male
Phenanthridines/*pharmacology
Psychopharmacology
Rats
Receptors
Schechter M D
Sprague-Dawley