1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(93)90860-p" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(93)90860-p</a>
Pages
98–102
Issue
1
Volume
609
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-04
Subject
The topic of the resource
*Social Behavior; 1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*analogs & derivatives/pharmacology; Animals; Brain Chemistry/drug effects; Catecholamines/metabolism; Cognition/*drug effects; Dopamine Agents/*pharmacology; Dopamine/metabolism; Habituation; Levodopa/pharmacology; Male; Memory/*drug effects; Mice; Psychophysiologic/drug effects
Creator
An entity primarily responsible for making the resource
Dluzen D E; Kreutzberg J D
Description
An account of the resource
Male mice treated with MPTP or vehicle were tested for their ability to demonstrate a memory-recognition response as evaluated in a habituation-dishabituation task. Treatment with MPTP severely disrupted the male's habituation-dishabituation response profile compared to vehicle treated animals. Administration of L-DOPA at 45 min prior to behavioral testing in MPTP animals restored their performance on the habituation-dishabituation test to levels observed in vehicle treated animals. There was also a tendency for L-DOPA to produce enhanced responsiveness in vehicle treated animals. Mice treated with MPTP had significantly reduced concentrations of norepinephrine within the olfactory bulb and hippocampus. Vehicle treated mice administered L-DOPA had significantly increased dopamine concentrations within the corpus striatum. These results suggest that, in addition to its putative effects upon the nigrostriatal dopaminergic system and motor behavior, MPTP is also exerting substantial effects upon other systems. In particular, the noradrenergic system and its potential involvement with memory/recognition processes in the CD-1 mouse appears to be very sensitive to the neurotoxic effects of MPTP.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(93)90860-p" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(93)90860-p</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
1-Methyl-4-phenyl-1
1993
2
3
6-tetrahydropyridine/*analogs & derivatives/pharmacology
Animals
Brain Chemistry/drug effects
Brain research
Catecholamines/metabolism
Cognition/*drug effects
Dluzen D E
Dopamine Agents/*pharmacology
Dopamine/metabolism
Habituation
Kreutzberg J D
Levodopa/pharmacology
Male
Memory/*drug effects
Mice
Psychophysiologic/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(94)90014-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(94)90014-0</a>
Pages
575–584
Issue
3
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
Animals; Avoidance Learning/*drug effects; Blood Platelets/metabolism; Brain Chemistry/genetics; Fenfluramine/*pharmacology; Habituation; Inbred Strains; Platelet Storage Pool Deficiency/physiopathology; Psychophysiologic/drug effects; Rats; Serotonin/metabolism/physiology; Species Specificity; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Meehan S M; Schechter M D
Description
An account of the resource
The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain serotonergic levels or function remains unclear, numerous behavioral studies have indicated that FH rats exhibit differential responses to serotonergic agonists and antagonist relative to other strains. The current study used the conditioned place preference paradigm to examine the ability of fenfluramine to produce a conditioned place preference (CPP) or aversion (CPA) in FH and Sprague-Dawley (SD) rats. Results indicated that fenfluramine failed to produce CPP or CPA in SD rats, but did produce a CPA in FH rats. Results are discussed in terms of the use of conditioned place preference to assess putative differences in serotonergic functioning in FH rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(94)90014-0" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(94)90014-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Animals
Avoidance Learning/*drug effects
Blood Platelets/metabolism
Brain Chemistry/genetics
Fenfluramine/*pharmacology
Habituation
Inbred Strains
Meehan S M
Platelet Storage Pool Deficiency/physiopathology
Progress in neuro-psychopharmacology & biological psychiatry
Psychophysiologic/drug effects
Rats
Schechter M D
Serotonin/metabolism/physiology
Species Specificity
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(93)90102-h" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(93)90102-h</a>
Pages
695–700
Issue
5
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Extinction of cocaine-induced place approach in rats: a validation of the "biased" conditioning procedure.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1905-06
Subject
The topic of the resource
Animals; Classical; Cocaine/*pharmacology; Conditioning; Extinction; Habituation; Inbred Strains; Male; Operant/*drug effects; Psychological/*drug effects; Psychophysiologic/drug effects; Rats; Reward
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
It has often been demonstrated that when a rat is conditioned in a cue-specific environment that has been repeatedly paired with cocaine injections, it will spend more time in that environment than it does in a saline-paired environment. This behavioral procedure is commonly known as the conditioned place preference (CPP)-test. At present, a firm theoretical understanding of the mechanisms underlying the production of a CPP are unknown. It is insufficient merely to know that a CPP can result after repeated drug pairings. Rather, it is necessary that the procedure is validated within a learning theory framework. The objective of the present study was, therefore, to establish that what is observed in place preference studies was, indeed, conditioning. This was accomplished by determining whether a cocaine-induced increase in time spent in a drug-paired environment was subject to attenuation following extinction trials. Rats were tested for their initial bias in spending more time in one of two stimulus-specific chambers of a place-conditioning apparatus. On four occasions, rats were injected with 2.5 mg/kg cocaine and confined to their less-preferred chamber whereas, on four alternating sessions, they were conditioned with saline (vehicle) in their preferred chamber. Subsequent testing in the nondrugged state revealed that these rats displayed a significant increase in the time spent in their initially least-preferred environment compared to baseline measurements. Following establishment of this cocaine-induced CPP, the rats were injected only with saline and conditioned for an equal number of sessions (i.e., four).(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(93)90102-h" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(93)90102-h</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Animals
Brain research bulletin
Calcagnetti D J
Classical
Cocaine/*pharmacology
Conditioning
Extinction
Habituation
Inbred Strains
Male
Operant/*drug effects
Psychological/*drug effects
Psychophysiologic/drug effects
Rats
Reward
Schechter M D