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Text
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URL Address
<a href="http://doi.org/10.1164/ajrccm.158.3.9802031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1164/ajrccm.158.3.9802031</a>
Pages
760–768
Issue
3
Volume
158
Dublin Core
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Title
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Adrenal epinephrine increases alveolar liquid clearance in a canine model of neurogenic pulmonary edema.
Publisher
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American journal of respiratory and critical care medicine
Date
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1998
1998-09
Subject
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Adrenal Glands/*metabolism; Adrenalectomy; Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use; Adrenergic beta-Antagonists/therapeutic use; Amiloride/therapeutic use; Animal; Animals; Blood; Blood Pressure; Brain Diseases/chemically induced/*complications; Central Nervous System Agents/adverse effects; Cisterna Magna; Disease Models; Diuretics/therapeutic use; Dogs; Epinephrine/blood/*physiology/therapeutic use; Extravascular Lung Water/chemistry/*metabolism; Female; Hypertension; Injections; Male; Propanolamines/therapeutic use; Proteins/analysis; Pulmonary Alveoli/*metabolism; Pulmonary Artery; Pulmonary Edema/etiology/*metabolism/prevention & control; Pulmonary/prevention & control; Sodium Channel Blockers; Veratrine/adverse effects
Creator
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Lane S M; Maender K C; Awender N E; Maron M B
Description
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Case reports of neurogenic pulmonary edema (NPE) often indicate that the edema resolves quickly. Because plasma epinephrine concentration may be elevated in NPE, and epinephrine has been shown to increase the rate of alveolar liquid clearance (ALC), we determined if ALC was increased in a canine model of NPE produced by the intracisternal administration of veratrine. ALC was determined by instilling autologous plasma into a lower lung lobe and using the increase in instillate protein concentration after 4 h to calculate the volume of fluid cleared from the airspaces by mass balance. To prevent pulmonary hypertension and edema, which would confound the mass balance analysis, carotid arterial blood was allowed to drain into a reservoir as pulmonary arterial pressure started to rise after veratrine administration. ALC in animals administered veratrine (n = 6) was 30.4 +/- 1.6 (SE)% of the instilled volume compared with 14.1 +/- 2.1% observed in control animals. The increase in ALC could be inhibited by adrenalectomy, beta2-adrenergic blockade using ICI 118,551, or sodium channel blockade using amiloride and could be duplicated by infusing epinephrine to increase plasma epinephrine concentration to levels observed in NPE. These data indicate that the increased ALC was mediated by adrenal epinephrine and suggest that edema resolution in patients with NPE might be accelerated by endogenous epinephrine.
Identifier
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<a href="http://doi.org/10.1164/ajrccm.158.3.9802031" target="_blank" rel="noreferrer noopener">10.1164/ajrccm.158.3.9802031</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Adrenal Glands/*metabolism
Adrenalectomy
Adrenergic beta-Agonists/blood/*pharmacology/therapeutic use
Adrenergic beta-Antagonists/therapeutic use
American journal of respiratory and critical care medicine
Amiloride/therapeutic use
Animal
Animals
Awender N E
Blood
Blood Pressure
Brain Diseases/chemically induced/*complications
Central Nervous System Agents/adverse effects
Cisterna Magna
Disease Models
Diuretics/therapeutic use
Dogs
Epinephrine/blood/*physiology/therapeutic use
Extravascular Lung Water/chemistry/*metabolism
Female
Hypertension
Injections
Lane S M
Maender K C
Male
Maron M B
Propanolamines/therapeutic use
Proteins/analysis
Pulmonary Alveoli/*metabolism
Pulmonary Artery
Pulmonary Edema/etiology/*metabolism/prevention & control
Pulmonary/prevention & control
Sodium Channel Blockers
Veratrine/adverse effects