1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0026-2862(92)90006-b" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0026-2862(92)90006-b</a> Pages 60–72 Issue 1 Volume 43 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Effect of extreme elevations in venous pressure on reflection coefficient in the lung. Publisher An entity responsible for making the resource available Microvascular research Date A point or period of time associated with an event in the lifecycle of the resource 1992 1992-01 Subject The topic of the resource Animals; Blood Pressure/*physiology; Blood Proteins/analysis; Capillary Permeability/*physiology; Dogs; Endothelium; Female; Forelimb/physiology; Hematocrit; In Vitro Techniques; Lung/*drug effects/physiology; Male; Perfusion; Pulmonary Veins/*physiology; Solvents/*chemistry; Vascular/*drug effects Creator An entity primarily responsible for making the resource Maron M B; Lang S A Description An account of the resource We determined whether the solvent drag reflection coefficient (sigma f) for total proteins of a canine perfused left lower lung lobe (LLL) preparation decreases at elevated venous pressures (Pv). We found that sigma f (estimated using the hematocrit-protein technique) remained constant at all Pv's (30-95 mm Hg) evaluated. These results were unanticipated, since previous studies reported increases in protein permeability at Pv's within this range. We conducted two additional studies to better understand the basis for these observations. In the first, we evaluated the effect of high Pv (85 mm Hg) on sigma f of a canine perfused forelimb preparation and found sigma f to be reduced. This difference in response suggests that the normal sigma f's observed in the LLL were not due to high Pv per se, but rather that there is some intrinsic difference between the pulmonary and the systemic circulations that accounts for the difference. The second study was designed to determine whether the normal sigma f's observed in the LLL at high Pv's provide meaningful information about pulmonary vascular endothelial permeability. We damaged LLL's with alloxan, oleic acid, or HCl and obtained near normal estimates of sigma f at high Pv. These results indicated that it is not possible to easily distinguish between a normal and a damaged pulmonary vasculature when sigma f is measured at high Pv. We suggest that the normal estimates of sigma f obtained at high Pv in the LLL results from an increased fraction of the transvascular flow occurring through pathways that exclude macromolecules. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0026-2862(92)90006-b" target="_blank" rel="noreferrer noopener">10.1016/0026-2862(92)90006-b</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1992 Animals Blood Pressure/*physiology Blood Proteins/analysis Capillary Permeability/*physiology Dogs Endothelium Female Forelimb/physiology Hematocrit In Vitro Techniques Lang S A Lung/*drug effects/physiology Male Maron M B Microvascular research Perfusion Pulmonary Veins/*physiology Solvents/*chemistry Vascular/*drug effects