1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0892-0362(88)90090-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0892-0362(88)90090-6</a> Pages 539–548 Issue 6 Volume 10 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Triethyltin exposure suppresses synaptic transmission in area CA1 of the rat hippocampal slice. Publisher An entity responsible for making the resource available Neurotoxicology and teratology Date A point or period of time associated with an event in the lifecycle of the resource 1988 1988-12 Subject The topic of the resource Female; Animals; Rats; In Vitro Techniques; Synapses/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Hippocampus/drug effects/*pathology/physiology; Pyramidal Tracts/drug effects/*pathology/physiology; Trialkyltin Compounds/*toxicity; Triethyltin Compounds/*toxicity Creator An entity primarily responsible for making the resource Fountain S B; Ting Y L; Hennes S K; Teyler T J Description An account of the resource To examine the effects of TET on the electrophysiology of area CA1 of hippocampus, hippocampal slices were obtained from adult hooded rats and were maintained in vitro using standard techniques. Stimulating and recording electrodes were placed in the Schaffer collaterals and CA1 pyramidal cell body layer, respectively. Following baseline measurements, slices were exposed to either 0, 1, 3, 6, or 10 microM TET in the incubating medium. Both pyramidal cell excitability and recurrent/feedforward inhibition were suppressed in a dose-dependent manner within 3 hr postexposure. The evoked population spike and population excitatory postsynaptic potential (EPSP) were suppressed significantly by 2 hr postexposure for 1 and 3 microM TET exposures, and by 45 min postexposure for 6 and 10 microM exposures. A similar dose-dependency was observed for the suppression of recurrent/feedforward inhibition in hippocampal CA1. A second procedure tested the specificity of TET effects to axonal conduction of Schaffer collaterals. Both the stimulating and recording electrode were placed in the Schaffer collaterals so that both the Schaffer collateral population fiber volley and the CA1 pyramidal cell population EPSP could be recorded. TET exposure suppressed pyramidal cell EPSPs without significantly affecting the amplitude of Schaffer collateral fiber volleys. The results support the view that acute TET exposure suppresses synaptic transmission in area CA1 of hippocampus. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0892-0362(88)90090-6" target="_blank" rel="noreferrer noopener">10.1016/0892-0362(88)90090-6</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1988 Animals Evoked Potentials/drug effects Female Fountain S B Hennes S K Hippocampus/drug effects/*pathology/physiology In Vitro Techniques Neurotoxicology and teratology Pyramidal Tracts/drug effects/*pathology/physiology Rats Synapses/drug effects/*physiology Synaptic Transmission/*drug effects Teyler T J Ting Y L Trialkyltin Compounds/*toxicity Triethyltin Compounds/*toxicity