1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0031-9384(95)02119-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0031-9384(95)02119-1</a> Pages 597–604 Issue 4 Volume 59 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference. Publisher An entity responsible for making the resource available Physiology & behavior Date A point or period of time associated with an event in the lifecycle of the resource 1996 1996-05 Subject The topic of the resource Animals; Body Weight/drug effects/physiology; Cocaine/*pharmacology; Conditioning; Male; Narcotics/*pharmacology; Olfaction Disorders/psychology; Olfactory Bulb/anatomy & histology/*physiology; Operant/*drug effects; Rats; Reward; Smell/drug effects/*physiology; Sulfates/pharmacology; Zinc Compounds/pharmacology; Zinc Sulfate Creator An entity primarily responsible for making the resource Calcagnetti D J; Quatrella L A; Schechter M D Description An account of the resource The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p \textless 0.05) increase (double) the seconds spent in their least-preferred chamber following cocaine-chamber pairings. Subsequently, groups of rats underwent one of three treatments: 1) olfactory bulbectomy (BULBX), 2) sham surgery (SHAM), or 3) sham surgery plus intranasal zinc sulfate perfusion (ZnSO4). Zinc sulfate was used to produce a temporary loss of olfaction. In a separate behavioral measure of olfactory acuity, both BULBX and ZnSO4-treated rats performed at an equally deficient level, in contrast to SHAM-treated rats that were not rendered anosmic. A second conditioned place preference test revealed that the ZnSO4-perfused and SHAM groups did not differ from their original postcocaine preference measurements. In contrast, the BULBX group spent significantly fewer seconds in the cocaine-paired chamber. After a 14-day interval, a third preference test revealed that SHAM and ZnSO4-treated rats displayed an equivalent preference for the cocaine-paired chamber (at 2.7 times above baseline). Interestingly, the seconds spent in the cocaine-paired chamber by BULBX rats did not differ from their baseline (e.g., precocaine exposure). These results suggest that bulbectomy disrupts the expression of cocaine-induced place preference. Interpretations of data from BULBX rats involving the production of an anhedonic condition and the relevance of olfactory bulbectomy as an animal model of anhedonic depression are discussed. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0031-9384(95)02119-1" target="_blank" rel="noreferrer noopener">10.1016/0031-9384(95)02119-1</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1996 Animals Body Weight/drug effects/physiology Calcagnetti D J Cocaine/*pharmacology Conditioning Male Narcotics/*pharmacology Olfaction Disorders/psychology Olfactory Bulb/anatomy & histology/*physiology Operant/*drug effects Physiology & behavior Quatrella L A Rats Reward Schechter M D Smell/drug effects/*physiology Sulfates/pharmacology Zinc Compounds/pharmacology Zinc Sulfate Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/0024-3205(94)00414-n" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0024-3205(94)00414-n</a> Pages 475–483 Issue 7 Volume 56 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics. Publisher An entity responsible for making the resource available Life sciences Date A point or period of time associated with an event in the lifecycle of the resource 1995 1905-06 Subject The topic of the resource Animals; Calcium Channel Blockers/pharmacology/therapeutic use; Cocaine/*antagonists & inhibitors; Conditioning (Psychology)/*drug effects; Humans; Narcotic Antagonists/pharmacology; Serotonin Antagonists/pharmacology; Substance-Related Disorders/*drug therapy Creator An entity primarily responsible for making the resource Calcagnetti D J; Keck B J; Quatrella L A; Schechter M D Description An account of the resource Conditioned place preference/aversion testing is a behavioral method believed capable of measuring the affective (positive, neutral or negative) properties of psychoactive drugs. Cocaine injections in rats reliably produces a positive place preference. Drugs that attenuate or block this effect of cocaine have obvious potential for developing treatments to address cocaine addiction as well as to add to the scientific understanding of the mechanism of cocaine's action at the cellular level. To date, six drugs have been reported to block the expression of a cocaine-induced conditioned place preference (CPP) and this review evidences the cocaine-induced CPP blockage by the two potent L-type calcium channel blockers, isradipine and nifedipine, the two serotonin-3 receptor antagonists, MDL72222 and ICS205-930, the delta opioid receptor selective antagonist naltrindole, and lastly, a mixed opioid agonist-antagonist buprenorphine. Additional evidence relating to the blockade of other cocaine behavioral effects by these putative blockers is addressed, where appropriate, from studies employing other procedures such as drug stimulus discrimination, self-administration, electrical brain stimulation and increases in locomotor activity. The significance of these findings is discussed in the context of their relevance to the development of treatment regimens to allow for cessation of cocaine abuse. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/0024-3205(94)00414-n" target="_blank" rel="noreferrer noopener">10.1016/0024-3205(94)00414-n</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 1995 Animals Calcagnetti D J Calcium Channel Blockers/pharmacology/therapeutic use Cocaine/*antagonists & inhibitors Conditioning (Psychology)/*drug effects Humans Keck B J Life sciences Narcotic Antagonists/pharmacology Quatrella L A Schechter M D Serotonin Antagonists/pharmacology Substance-Related Disorders/*drug therapy