1
40
11
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90831-d</a>
Pages
101–104
Issue
1
Volume
124
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence for mu opiate receptors on inhibitory terminals in area CA1 of rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
Animals; Rats; Action Potentials/drug effects; Quinoxalines/pharmacology; Bicuculline/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Ion Channel Gating/drug effects; Barium/pharmacology; Dendrites/chemistry; Enkephalins/metabolism/pharmacology; Hippocampus/*chemistry/ultrastructure; Naloxone/pharmacology; Nerve Endings/chemistry; Potassium Channels/drug effects; Receptors; Enkephalin; Opioid; Ala(2)-MePhe(4)-Gly(5)-; GABA-A/drug effects/physiology; mu; Opioid/*analysis
Creator
An entity primarily responsible for making the resource
Lambert N A; Harrison N L; Teyler T J
Description
An account of the resource
The mechanism of disinhibition produced by opioid peptides was studied using intracellular recording in area CA1 of rat hippocampal slices. The mu-selective opioid peptide [D-Ala2,N-Me-Phe4,Gly-ol5]-enkephalin (DAGO) reversibly depressed directly-activated, monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV) in a naloxone-sensitive manner. Depression of monosynaptic inhibitory postsynaptic potentials (IPSPs) by DAGO was not prevented by 1-2 mM Ba2+. DAGO reversibly depressed monosynaptic IPSPs when applied locally close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that DAGO disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating mu opiate receptors located on the terminals of inhibitory neurons, and by a Ba(2+)-insensitive mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90831-d" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90831-d</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Ala(2)-MePhe(4)-Gly(5)-
Animals
Barium/pharmacology
Bicuculline/pharmacology
Dendrites/chemistry
Enkephalin
Enkephalins/metabolism/pharmacology
GABA-A/drug effects/physiology
Harrison N L
Hippocampus/*chemistry/ultrastructure
Ion Channel Gating/drug effects
Lambert N A
mu
Naloxone/pharmacology
Nerve Endings/chemistry
Neuroscience letters
Opioid
Opioid/*analysis
Potassium Channels/drug effects
Quinoxalines/pharmacology
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)90985-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)90985-5</a>
Pages
349–352
Issue
2
Volume
547
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Baclofen-induced disinhibition in area CA1 of rat hippocampus is resistant to extracellular Ba2+.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-05
Subject
The topic of the resource
Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Hippocampus/*drug effects; Evoked Potentials/drug effects; Baclofen/antagonists & inhibitors/*pharmacology; Barium/*pharmacology; Drug Resistance/physiology; Interneurons/drug effects; Neural Inhibition/drug effects; Receptors; GABA-A/*drug effects
Creator
An entity primarily responsible for making the resource
Lambert N A; Harrison N L; Teyler T J
Description
An account of the resource
The mechanism of disinhibition produced by (+/-)-baclofen was studied using intracellular recording in area CA1 of rat hippocampal slices. Baclofen reversibly depressed monosynaptic IPSPs evoked by direct activation of interneurons in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Ba2+ prevented baclofen-induced hyperpolarization of pyramidal neurons but not depression of monosynaptic IPSPs by baclofen. Baclofen reversibly depressed monosynaptic IPSPs when applied close to the recording site, but was ineffective when applied close to the stimulating site in stratum radiatum. These results suggest that baclofen disinhibits pyramidal neurons in area CA1 of the rat hippocampus by activating receptors on the terminals of inhibitory neurons that are coupled to a Ba(2+)-insensitive effector mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)90985-5" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)90985-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Baclofen/antagonists & inhibitors/*pharmacology
Barium/*pharmacology
Brain research
Drug Resistance/physiology
Evoked Potentials/drug effects
GABA-A/*drug effects
Harrison N L
Hippocampus/*drug effects
In Vitro Techniques
Interneurons/drug effects
Lambert N A
Neural Inhibition/drug effects
Quinoxalines/pharmacology
Rats
Receptors
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90190-5</a>
Pages
50–52
Issue
1
Volume
122
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Animals; Rats; In Vitro Techniques; Quinoxalines/pharmacology; 2-Amino-5-phosphonovalerate/pharmacology; Membrane Potentials/drug effects; Hippocampus/drug effects/*physiology; Evoked Potentials/drug effects; Synaptic Transmission/*drug effects; Adenosine/*pharmacology; Synapses/*drug effects; Theophylline/analogs & derivatives/pharmacology
Creator
An entity primarily responsible for making the resource
Lambert N A; Teyler T J
Description
An account of the resource
The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late IPSPs evoked by direct activation of interneurons in the presence of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). Directly activated IPSPs were unchanged by the selective adenosine A1 receptor antagonist 8-cyclopentyltheophylline (CPT), but CPT reversed hyperpolarization and depression of late IPSPs produced by adenosine. These results indicate that adenosine depresses disynaptic IPSPs in area CA1 by decreasing synaptic activation of inhibitory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90190-5" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90190-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Adenosine/*pharmacology
Animals
Evoked Potentials/drug effects
Hippocampus/drug effects/*physiology
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neuroscience letters
Quinoxalines/pharmacology
Rats
Synapses/*drug effects
Synaptic Transmission/*drug effects
Teyler T J
Theophylline/analogs & derivatives/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.2894-06.2007</a>
Pages
1954–1963
Issue
8
Volume
27
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Contribution of NMDA and AMPA receptors to temporal patterning of auditory responses in the inferior colliculus.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Neurons/physiology; Action Potentials/drug effects; Excitatory Amino Acid Antagonists/pharmacology; Quinoxalines/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Piperazines/pharmacology; *Acoustic Stimulation; Reaction Time/drug effects/*physiology; N-Methyl-D-Aspartate/*physiology; Receptors; AMPA/*physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
Although NMDA receptors (NMDARs) are associated with synaptic plasticity, they form an essential part of responses to sensory stimuli. We compared contributions of glutamatergic NMDARs and AMPA receptors (AMPARs) to auditory responses in the inferior colliculus (IC) of awake, adult mustached bats. We examined the magnitude and temporal pattern of responses to tonal signals in single units before, during, and after local micro-iontophoretic application of selective antagonists to AMPARs [NBQX (1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide)] and NMDARs [CPP ((+/-)3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid)]. Combined blockade of AMPARs and NMDARs eliminated excitatory responses in nearly all neurons, whereas separate blockade of each receptor was quantitatively similar, causing substantial (\textgreater 50%) spike reductions in approximately 75% of units. The major result was that effects of receptor blockade were most closely related to the first-spike latency of a unit. Thus, AMPAR blockade substantially reduced spikes in all short-latency units (\textless 12 ms) but never in long-latency units (\textgreater or = 12 ms). NMDAR blockade had variable effects on short-latency units but reduced spikes substantially for all long-latency units. There were no distinct contributions of AMPARs and NMDARs to early and late elements of responses. Thus, AMPAR blockade reduced early (onset) spikes somewhat more effectively than NMDAR blockade in short-latency units, but NMDAR blockade reduced onset spikes more effectively in long-latency units. AMPAR and NMDAR blockade were equally effective in reducing later elements of sustained responses in short-latency units, whereas NMDAR blockade was much more effective in long-latency units. These results indicate that NMDARs play multiple roles for signal processing in adult IC neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.2894-06.2007" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.2894-06.2007</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2007
Action Potentials/drug effects
AMPA/*physiology
Animals
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Excitatory Amino Acid Antagonists/pharmacology
Gans Donald
Inferior Colliculi/cytology/drug effects/*physiology
N-Methyl-D-Aspartate/*physiology
NEOMED College of Medicine
Neurons/physiology
Piperazines/pharmacology
Quinoxalines/pharmacology
Reaction Time/drug effects/*physiology
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.1991.66.5.1538</a>
Pages
1538–1548
Issue
5
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Hyperpolarizing and depolarizing GABAA receptor-mediated dendritic inhibition in area CA1 of the rat hippocampus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-11
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Animals; Bicuculline/analogs & derivatives/pharmacology; Chlorides/pharmacology; Dendrites/drug effects/*physiology; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; GABA-A/drug effects/*physiology; Hippocampus/*physiology; In Vitro Techniques; Kinetics; Mathematics; Membrane Potentials/drug effects; Models; Neurological; Neurons/drug effects/*physiology; Organophosphorus Compounds/pharmacology; Pyramidal Tracts/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Borroni A M; Grover L M; Teyler T J
Description
An account of the resource
1. gamma-Aminobutyric acidA (GABAA) receptor-mediated inhibition of pyramidal neuron dendrites was studied in area CA1 of the rat hippocampal slice preparation with the use of intracellular and extracellular recording and one-dimensional current source-density (CSD) analysis. 2. Electrical stimulation of Schaffer collateral/commissural fibers evoked monosynaptic excitatory postsynaptic potentials (EPSPs) and population EPSPs, which were followed by biphasic inhibitory postsynaptic potentials (IPSPs). In the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV), stimulation in stratum radiatum evoked monosynaptic fast, GABAA and late, GABAB receptor-mediated IPSPs and fast and late positive field potentials recorded in s. radiatum. 3. Fast monosynaptic IPSPs and fast positive field potentials evoked in the presence of DNQX and APV were reversibly abolished by the GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) and were not changed by the GABAB receptor antagonist
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.1991.66.5.1538" target="_blank" rel="noreferrer noopener">10.1152/jn.1991.66.5.1538</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Animals
Bicuculline/analogs & derivatives/pharmacology
Borroni A M
Chlorides/pharmacology
Dendrites/drug effects/*physiology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
GABA-A/drug effects/*physiology
Grover L M
Hippocampus/*physiology
In Vitro Techniques
Journal of neurophysiology
Kinetics
Lambert N A
Mathematics
Membrane Potentials/drug effects
Models
Neurological
Neurons/drug effects/*physiology
Organophosphorus Compounds/pharmacology
Pyramidal Tracts/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00657.2016</a>
Pages
2550–2563
Issue
6
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-type calcium channels refine the neural population code of sound level.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
*auditory midbrain; *dynamic range; *inferior colliculus; *level tuning; *local circuits; *rate-level functions; *Sound; 4-Aminopyridine/analogs & derivatives/pharmacology; Acoustic Stimulation; Action Potentials/drug effects/*physiology; Amifampridine; Animals; Biophysical Phenomena/drug effects; Calcium Channel Blockers/pharmacology; Calcium Channels; Calcium/metabolism; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Inbred CBA; Inferior Colliculi/*cytology; L-Type/*metabolism; Mice; Neurons/*physiology; Nimodipine/pharmacology; omega-Conotoxin GVIA/pharmacology; Potassium Channel Blockers/pharmacology; Quinoxalines/pharmacology; Wakefulness
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Green David Brian; Sivaramakrishnan Shobhana
Description
An account of the resource
The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises approximately 50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">10.1152/jn.00657.2016</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*auditory midbrain
*dynamic range
*Inferior colliculus
*level tuning
*local circuits
*rate-level functions
*Sound
2016
4-Aminopyridine/analogs & derivatives/pharmacology
Acoustic Stimulation
Action Potentials/drug effects/*physiology
Amifampridine
Animals
Biophysical Phenomena/drug effects
Calcium Channel Blockers/pharmacology
Calcium Channels
Calcium/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Green David Brian
Grimsley Calum Alex
In Vitro Techniques
Inbred CBA
Inferior Colliculi/*cytology
Journal of neurophysiology
L-Type/*metabolism
Mice
Neurons/*physiology
Nimodipine/pharmacology
omega-Conotoxin GVIA/pharmacology
Potassium Channel Blockers/pharmacology
Quinoxalines/pharmacology
Sivaramakrishnan Shobhana
Wakefulness
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-3806(98)00100-x</a>
Pages
115–119
Issue
1
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
GABAa receptor-mediated field potentials are enhanced in area CA1 following prenatal cocaine exposure.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-09
Subject
The topic of the resource
*Prenatal Exposure Delayed Effects; AMPA/physiology; Animals; Bicuculline/analogs & derivatives/pharmacology; Cocaine/*pharmacology; Female; GABA-A/*physiology; GABA-B/physiology; Hippocampus/drug effects/*physiology; In Vitro Techniques; Membrane Potentials/drug effects/physiology; N-Methyl-D-Aspartate/physiology; Pregnancy; Quinoxalines/pharmacology; Rabbits; Receptors; Synapses/drug effects/physiology
Creator
An entity primarily responsible for making the resource
Little J Z; Teyler T J
Description
An account of the resource
Prenatal cocaine exposure results in several documented changes in neurotransmitter receptor number and structure. Increases have been reported for cortical catecholamine and indoleamine receptor number and binding affinity, in the subunit expression of glutamatergic NMDA and AMPA receptors in the striatum, and in GABA immunoreactivity in the anterior cingulate cortex. We sought information on the functional consequences of cocaine-induced alterations in receptor structure/number. Since hippocampal amino acid neurotransmitters are of critical importance and have been shown to be affected by cocaine, we studied field potentials produced by synaptic activation of isolated glutamatergic NMDA and AMPA receptors and GABAa and GABAb responsive receptors in area CA1 of rabbit hippocampal slices. We found the GABAa receptor population produced significantly larger field potentials in cocaine-exposed offspring compared to controls, while other receptors produced responses similar to controls.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-3806(98)00100-x" target="_blank" rel="noreferrer noopener">10.1016/s0165-3806(98)00100-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prenatal Exposure Delayed Effects
1998
AMPA/physiology
Animals
Bicuculline/analogs & derivatives/pharmacology
Brain research. Developmental brain research
Cocaine/*pharmacology
Female
GABA-A/*physiology
GABA-B/physiology
Hippocampus/drug effects/*physiology
In Vitro Techniques
Little J Z
Membrane Potentials/drug effects/physiology
N-Methyl-D-Aspartate/physiology
Pregnancy
Quinoxalines/pharmacology
Rabbits
Receptors
Synapses/drug effects/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2008.08.037" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2008.08.037</a>
Pages
987–994
Issue
4
Volume
156
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Localization and function of NK(3) subtype tachykinin receptors of layer V pyramidal neurons of the guinea-pig medial prefrontal cortex.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
Animals; Autoradiography/methods; Dose-Response Relationship; Drug; Drug Interactions; Excitatory Amino Acid Antagonists/pharmacology; Excitatory Postsynaptic Potentials/drug effects/radiation effects; Guinea Pigs; In Vitro Techniques; Iodine Isotopes/pharmacokinetics; Male; Membrane Potentials/drug effects/physiology/radiation effects; Neurokinin B/analogs & derivatives/pharmacokinetics; Neurokinin-3/agonists/antagonists & inhibitors/*metabolism; Patch-Clamp Techniques; Peptide Fragments/pharmacology; Prefrontal Cortex/*cytology; Protein Binding/drug effects; Pyramidal Cells/drug effects/*metabolism; Quinolines/pharmacology; Quinoxalines/pharmacology; Receptors; Substance P/analogs & derivatives/pharmacology; Valine/analogs & derivatives/pharmacology
Creator
An entity primarily responsible for making the resource
Simmons M A; Sobotka-Briner C D; Medd A M
Description
An account of the resource
The NK(3) subtype of tachykinin receptor has been implicated as a modulator of synaptic transmission in several brain regions, including the cerebral cortex. The localization and expression of NK(3) receptors within the brain vary from species to species. In addition, the pharmacology of NK(3) receptor-specific antagonists shows significant species variability. Among commonly used animal models, the pharmacology of the guinea-pig NK(3) receptor most closely resembles that of the human NK(3) receptor. Here, we provide anatomical localization studies, receptor binding studies, and studies of the electrophysiological effects of NK(3) receptor ligands of guinea-pig cortex using two commercially available ligands, the NK(3) receptor peptide analog agonist senktide, and the quinolinecarboxamide NK(3) receptor antagonist SB-222,200. Saturation binding studies with membranes isolated from guinea-pig cerebral cortex showed saturable binding consistent with a single high affinity site. Autoradiographic studies revealed dense specific binding in layers II/III and layer V of the cerebral cortex. For electrophysiological studies, brain slices were prepared from prefrontal cortex of 3- to 14-day-old guinea pigs. Whole cell recordings were made from layer V pyramidal neurons. In current clamp mode with a K(+)-containing pipette solution, senktide depolarized the pyramidal neurons and led to repetitive firing of action potentials. In voltage clamp mode with a Cs(+)-containing pipette solution, senktide application produced an inward current and a concentration-dependent enhancement of the amplitude and the frequency of spontaneous excitatory postsynaptic potentials. The glutamatergic nature of these events was demonstrated by block by glutamate receptor antagonists. The effects of senktide were blocked by SB-222,200, an NK(3) receptor antagonist. Taken together, these results are consistent with a functional role for NK(3) receptors located on neurons in the cerebral cortex. In layer V pyramidal neurons of the medial prefrontal cortex, activation of the NK(3) receptor system plays an excitatory role in modulating synaptic transmission.
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<a href="http://doi.org/10.1016/j.neuroscience.2008.08.037" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2008.08.037</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
Animals
Autoradiography/methods
Dose-Response Relationship
Drug
Drug Interactions
Excitatory Amino Acid Antagonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects/radiation effects
Guinea Pigs
In Vitro Techniques
Iodine Isotopes/pharmacokinetics
Male
Medd A M
Membrane Potentials/drug effects/physiology/radiation effects
Neurokinin B/analogs & derivatives/pharmacokinetics
Neurokinin-3/agonists/antagonists & inhibitors/*metabolism
Neuroscience
Patch-Clamp Techniques
Peptide Fragments/pharmacology
Prefrontal Cortex/*cytology
Protein Binding/drug effects
Pyramidal Cells/drug effects/*metabolism
Quinolines/pharmacology
Quinoxalines/pharmacology
Receptors
Simmons M A
Sobotka-Briner C D
Substance P/analogs & derivatives/pharmacology
Valine/analogs & derivatives/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(92)90439-e" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(92)90439-e</a>
Pages
215–218
Issue
2
Volume
135
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Induction of giant depolarizing potentials by zinc in area CA1 of the rat hippocampus does not result from block of GABAB receptors.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-02
Subject
The topic of the resource
*GABA-A Receptor Antagonists; 2-Amino-5-phosphonovalerate/pharmacology; Animals; Baclofen/pharmacology; Hippocampus/cytology/*drug effects; In Vitro Techniques; Interneurons/drug effects/physiology; Membrane Potentials/drug effects; Quinoxalines/pharmacology; Rats; Synapses/drug effects; Zinc/*pharmacology
Creator
An entity primarily responsible for making the resource
Lambert N A; Levitin M; Harrison N L
Description
An account of the resource
The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potentials (IPSPs) were evoked in the presence of the excitatory amino acid (EAA) receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-amino-5-phosphonovalerate (APV). Addition of Zn2+ (0.3 mM) resulted in the appearance of long-lasting GDPs which obscured monosynaptic late IPSPs. The GABAA receptor antagonist bicuculline methiodide (BMI; 30 microM) blocked fast monosynaptic IPSPs and GDPs, revealing a monosynaptic late IPSP that was prolonged in the presence of Zn2+ and blocked by the GABAB receptor antagonist CGP 35,348 (100 microM). The selective GABAB receptor agonist baclofen (10 microM) depressed monosynaptic IPSPs and population excitatory postsynaptic potentials (pEPSPs) by acting at presynaptic GABAB receptors. Depression of synaptic potentials by baclofen was unaffected by Zn2+. These results suggest that induction of GDPs in area CA1 does not result from an action of Zn2+ at GABAB receptors. We suggest instead that Zn2+ induces GDPs by inducing synchronized discharge of GABAergic interneurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(92)90439-e" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(92)90439-e</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*GABA-A Receptor Antagonists
1992
2-Amino-5-phosphonovalerate/pharmacology
Animals
Baclofen/pharmacology
Harrison N L
Hippocampus/cytology/*drug effects
In Vitro Techniques
Interneurons/drug effects/physiology
Lambert N A
Levitin M
Membrane Potentials/drug effects
Neuroscience letters
Quinoxalines/pharmacology
Rats
Synapses/drug effects
Zinc/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90801-v</a>
Pages
129–131
Issue
1
Volume
203
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Action Potentials/drug effects; Adenosine/pharmacology; Animals; Baclofen/pharmacology; Carbachol/pharmacology; Cholinergic/*drug effects; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; Hippocampus/*drug effects; In Vitro Techniques; Membrane Potentials/drug effects; Neurons/*drug effects; Parasympathetic Nervous System/*drug effects; Phorbol Esters/pharmacology; Quinoxalines/pharmacology; Rats; Receptors; Synaptic Transmission/physiology
Creator
An entity primarily responsible for making the resource
Lambert N A; Teyler T J
Description
An account of the resource
We studied the effects of carbamylcholine (carbachol; CCh) on monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). CCh (30 microM) blocked late afterhyperpolarizations but did not depress GABAA receptor-mediated fast monosynaptic IPSPs or GABAB receptor-mediated late monosynaptic IPSPs. In the presence of CCh the GABAB receptor agonist (+/- )-baclofen (2 microM) reversibly hyperpolarized pyramidal neurons and depressed monosynaptic IPSPs as under control conditions. Phorbol-12,13-diacetate (PDAc; 10 microM) increased fast and depressed late monosynaptic IPSPs, and prevented depression of IPSPs by baclofen. These results suggest that cholinergic disinhibition in area CA1 of the hippocampus results from decreased synaptic excitation of inhibitory neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90801-v</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Adenosine/pharmacology
Animals
Baclofen/pharmacology
Carbachol/pharmacology
Cholinergic/*drug effects
European journal of pharmacology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
Hippocampus/*drug effects
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neurons/*drug effects
Parasympathetic Nervous System/*drug effects
Phorbol Esters/pharmacology
Quinoxalines/pharmacology
Rats
Receptors
Synaptic Transmission/physiology
Teyler T J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(91)91197-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(91)91197-9</a>
Pages
136–143
Issue
1
Volume
562
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
*Cortical Spreading Depression/drug effects; 2-Amino-5-phosphonovalerate/pharmacology; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Chloride/pharmacology; Electric Stimulation; Evoked Potentials/drug effects; Ibotenic Acid/analogs & derivatives/pharmacology; In Vitro Techniques; Kainic Acid/pharmacology; Magnesium/pharmacology; N-Methyl-D-Aspartate/drug effects/*physiology; Quinoxalines/pharmacology; Rats; Receptors; Synapses/physiology; Time Factors; Visual Cortex/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Aroniadou V A; Teyler T J
Description
An account of the resource
The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation consisted of two components with peak latencies at 5-8 ms (EPSP1) and 12-19 ms (EPSP2). EPSP2 appeared to be polysynaptic since it did not follow stimulation at 0.5 Hz. EPSP1 consisted of both kainate/AMPA and NMDA receptor activity, as revealed by bath application of DNQX and APV. EPSP2 displayed a variable sensitivity to bath-applied APV. Tetanic stimulation of the white matter in normal medium consistently induced long-term potentiation of EPSP1. In the presence of APV, LTP of EPSP1 was induced only when EPSP2 was still present, while there was no change, or LTD was induced, when EPSP2 was completely blocked by APV. In rat visual cortex, blockade of NMDA receptor participation in the postsynaptic response to tetanic stimulation reduces the probability for LTP induction but does not necessarily prevent LTP; synaptic strength may still change in either direction depending, in part, on factors affecting the magnitude of postsynaptic depolarization during tetanus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(91)91197-9" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(91)91197-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cortical Spreading Depression/drug effects
1991
2-Amino-5-phosphonovalerate/pharmacology
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Animals
Aroniadou V A
Brain research
Calcium Chloride/pharmacology
Electric Stimulation
Evoked Potentials/drug effects
Ibotenic Acid/analogs & derivatives/pharmacology
In Vitro Techniques
Kainic Acid/pharmacology
Magnesium/pharmacology
N-Methyl-D-Aspartate/drug effects/*physiology
Quinoxalines/pharmacology
Rats
Receptors
Synapses/physiology
Teyler T J
Time Factors
Visual Cortex/drug effects/*physiology