1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(96)00668-6</a>
Pages
PL83–90
Issue
6
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic mediation of fenfluramine discriminative stimuli in fawn-hooded rats.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1905-06
Subject
The topic of the resource
*Discrimination Learning; 4-methylenedioxyamphetamine/pharmacology; Animals; Dose-Response Relationship; Drug; Fenfluramine/administration & dosage/*pharmacology; Fluoxetine/pharmacology; Ibogaine/pharmacology; Male; Methoxydimethyltryptamines/pharmacology; N-Methyl-3; Piperazines/pharmacology; Quipazine/pharmacology; Rats; Serotonin Agents/administration & dosage/*pharmacology; Serotonin Receptor Agonists/pharmacology; Serotonin/*metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Fenfluramine, a drug that induces increased synaptic serotonin, was used to train Fawn-Hooded rats in a drug discrimination paradigm. This strain of rats is thought to possess a genetic serotonin storage abnormality. The intent of the study was to see if the Fawn-Hooded rat was similar or dissimilar to the more frequently used strain of Sprague-Dawley rat in its ability to learn to discriminate 2.0 mg/kg fenfluramine administered intraperitoneally. In addition, drugs presumed to work upon central serotonergic neurons were given to the fenfluramine-trained Fawn-Hooded rats to investigate if the cueing properties of the training drug generalized to other agents. Results indicate that the Fawn-Hooded rats learn to discriminate fenfluramine from its vehicle at the same rate, and with a similar sensitivity to lower doses, as do the Sprague-Dawley rats. Furthermore, fenfluramine was shown to completely generalize to MDMA (over 90%); TFMPP, m-CPP, quipazine and fluoxetine produced intermediate results (over 70%) and 5-MeODMT and ibogaine were vehicle-like (less than 70%). As these results coincide with those previously found in Sprague-Dawley rats, the conclusion is that the functional capacity to discriminate fenfluramine appears to be like that of other rat lines, and serotonergically-mediated, in the Fawn-Hooded rat. Suggestions to explain these results are offered and discussed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(96)00668-6" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(96)00668-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Discrimination Learning
1997
4-methylenedioxyamphetamine/pharmacology
Animals
Dose-Response Relationship
Drug
Fenfluramine/administration & dosage/*pharmacology
Fluoxetine/pharmacology
Ibogaine/pharmacology
Life sciences
Male
Methoxydimethyltryptamines/pharmacology
N-Methyl-3
Piperazines/pharmacology
Quipazine/pharmacology
Rats
Schechter M D
Serotonin Agents/administration & dosage/*pharmacology
Serotonin Receptor Agonists/pharmacology
Serotonin/*metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0303-7207(94)90168-6</a>
Pages
183–191
Issue
2
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Publisher
An entity responsible for making the resource available
Molecular and cellular endocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-11
Subject
The topic of the resource
5-Hydroxytryptophan/pharmacology; alpha-Methyltyrosine; Animals; Anterior/*chemistry/drug effects/metabolism; Blotting; Bromocriptine/pharmacology; Gene Expression Regulation/drug effects/physiology; Genetic; Haloperidol/pharmacology; Ketanserin/pharmacology; Male; Messenger/*analysis/genetics; Methiothepin/pharmacology; Methoxydimethyltryptamines/pharmacology; Methyltyrosines/pharmacology; Northern; Pituitary Gland; Prolactin/analysis/*genetics/metabolism; Quipazine/pharmacology; Rats; RNA; Serotonin/*physiology; Sprague-Dawley; Time Factors; Transcription; Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Creator
An entity primarily responsible for making the resource
Signs S A; Liu B; Wolford J; Carrillo A J
Description
An account of the resource
These studies examined the contribution of serotonin (5-HT) to the control of prolactin (PRL) and vasoactive intestinal peptide (VIP) messenger RNA expression in rat anterior pituitary. Daily injection of rats with the biosynthetic precursor to serotonin, 5-hydroxytryptophan (5-HTP; 25 mg/kg, q.i.d.), resulted on day 5 in a 50% increase in the expression of PRL mRNA in the pituitary while at the same time reducing the levels of both the 1.0 and 1.7 kb VIP mRNA transcripts. Co-treatment of rats with 5-HTP plus the catecholamine biosynthesis inhibitor, alpha-methyl-tyrosine (alpha-MT; 150 mg/kg, q.d. x 2 days), or the dopamine receptor antagonist haloperidol (1.25 mg/kg, b.i.d. x 5 days), resulted in increases in pituitary PRL message levels that were greater than those observed with either anti-dopaminergic agent alone. In contrast, 5-HTP was unable to reverse the inhibition of PRL mRNA expression caused by treatment with the dopamine receptor agonist bromocriptine (2.5 mg/kg, b.i.d. x 5 days). Neither alpha-MT, haloperidol nor bromocriptine had a significant effect on pituitary VIP mRNA expression. Administration of the direct-acting 5-HT receptor agonist quipazine (5 mg/kg, b.i.d.) for 14 consecutive days caused a significant increase in pituitary PRL mRNA levels on day 1 and reached a plateau of 90% above control levels on days 7 and 14. VIP mRNA levels rose significantly on day 1 of quipazine treatment but thereafter fell to a minimum of 22% (1.0 kb) and 52% (1.7 kb) of control by day 14.(ABSTRACT TRUNCATED AT 250 WORDS)
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0303-7207(94)90168-6" target="_blank" rel="noreferrer noopener">10.1016/0303-7207(94)90168-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5-Hydroxytryptophan/pharmacology
alpha-Methyltyrosine
Animals
Anterior/*chemistry/drug effects/metabolism
Blotting
Bromocriptine/pharmacology
Carrillo A J
Gene Expression Regulation/drug effects/physiology
Genetic
Haloperidol/pharmacology
Ketanserin/pharmacology
Liu B
Male
Messenger/*analysis/genetics
Methiothepin/pharmacology
Methoxydimethyltryptamines/pharmacology
Methyltyrosines/pharmacology
Molecular and cellular endocrinology
Northern
Pituitary Gland
Prolactin/analysis/*genetics/metabolism
Quipazine/pharmacology
Rats
RNA
Serotonin/*physiology
Signs S A
Sprague-Dawley
Time Factors
Transcription
Vasoactive Intestinal Peptide/analysis/*genetics/metabolism
Wolford J