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Text
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URL Address
<a href="http://doi.org/10.1006/bbrc.1995.1885" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/bbrc.1995.1885</a>
Pages
819–825
Issue
3
Volume
211
Dublin Core
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Title
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Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.
Publisher
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Biochemical and biophysical research communications
Date
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1995
1995-06
Subject
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Animals; Anterior/*metabolism; Base Sequence; Binding; Competitive; Cytoplasm/chemistry; Gene Expression Regulation; Genomic Library; Male; Messenger/*metabolism; Molecular Sequence Data; Pituitary Gland; Post-Transcriptional; Protein Binding; Proto-Oncogene Proteins c-fos/genetics; Rats; RNA; RNA Processing; RNA-Binding Proteins/*metabolism; RNA/metabolism; Sprague-Dawley; Subcellular Fractions; Tissue Distribution; Vasoactive Intestinal Peptide/*genetics
Creator
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Wolford J K; Signs S A
Description
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Multimeric AUUUA elements in an AU-rich 3'-untranslated region (3'-UTR) have been shown to confer message instability to numerous ephemeral transcripts through the formation of RNA-protein complexes. We show here that the 3'-UTR of VIP mRNA, which contains 3 AUUUA motifs in an AU-rich context, forms specific complexes with cytoplasmic proteins in a concentration-dependent, tissue-specific manner. We also demonstrate that an AU-rich segment of c-fos mRNA can successfully compete with VIP mRNA for binding with cytoplasmic proteins. These studies provide the first evidence for a mechanism by which VIP is post-transcriptionally regulated through specific sequences in its 3'-UTR.
Identifier
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<a href="http://doi.org/10.1006/bbrc.1995.1885" target="_blank" rel="noreferrer noopener">10.1006/bbrc.1995.1885</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Animals
Anterior/*metabolism
Base Sequence
Binding
Biochemical and biophysical research communications
Competitive
Cytoplasm/chemistry
Gene Expression Regulation
Genomic Library
Male
Messenger/*metabolism
Molecular Sequence Data
Pituitary Gland
Post-Transcriptional
Protein Binding
Proto-Oncogene Proteins c-fos/genetics
Rats
RNA
RNA Processing
RNA-Binding Proteins/*metabolism
RNA/metabolism
Signs S A
Sprague-Dawley
Subcellular Fractions
Tissue Distribution
Vasoactive Intestinal Peptide/*genetics
Wolford J K