Browse Items (90 total)
- Tags: RNA
MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1beta-stimulated human chondrocytes.
Tags: 2015, Academic Medical Centers, Aged, Arthritis & rheumatology (Hoboken, N.J.), Articular/drug effects/*metabolism, Cartilage, Cells, Chondrocytes – Physiology, Chondrocytes/drug effects/*metabolism, Cultured, Department of Anatomy & Neurobiology, Enzyme-Linked Immunosorbent Assay, Funding Source, Gene Knockdown Techniques, Haqqi Tariq M, Haseeb Abdul, Hip/*genetics/metabolism, Human, Humans, Immunoblotting – Utilization, Immunoprecipitation, Interleukin-1beta/pharmacology, Interleukin-6/*genetics/metabolism, Interleukins – Physiology, Makki Mohammad S, Messenger/drug effects/*metabolism, MicroRNAs/drug effects/*genetics/metabolism, Middle Aged, NEOMED College of Medicine, Ohio, Osteoarthritis, Osteoarthritis – Complications, Osteoarthritis – Physiopathology, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleases/drug effects/*genetics/metabolism, RNA, T-Tests, Transcription Factors/drug effects/*genetics/metabolism
Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.
Tags: *Gluconeogenesis, 2006, 8-Bromo Cyclic Adenosine Monophosphate/*pharmacology, Adolescent, Bile Acids and Salts/*biosynthesis, Cells, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics, Chromatin/metabolism, Cultured, Cyclic AMP-Dependent Protein Kinases/physiology, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Female, Gene Expression Regulation, Genetic/drug effects, Glucagon/*pharmacology, Hepatocyte Nuclear Factor 4/genetics/metabolism, Hepatocytes/*enzymology, Hepatology (Baltimore, Md.), Humans, Male, Messenger/analysis, Middle Aged, NEOMED College of Medicine, Organ Specificity, Phosphorylation, RNA, Song Kwang-Hoon, Transcription
Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells.
Tags: 2006, Bile Acids and Salts/*metabolism, Cells, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*genetics/metabolism, Cultured, Cytokines/*metabolism, Department of Integrative Medical Sciences, Gene Expression Regulation, Genetic, Hepatocytes/*cytology/drug effects, Hepatology (Baltimore, Md.), Humans, Immunoblotting, In Vitro Techniques, Interleukin-1/pharmacology, Jahan Asmeen, Li Tiangang, Messenger/analysis, NEOMED College of Medicine, Probability, Proto-Oncogene Proteins c-jun/*metabolism, Reverse Transcriptase Polymerase Chain Reaction, RNA, Sensitivity and Specificity, Signal Transduction/genetics, Transcription
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice.
Tags: 2013, Acetyl Coenzyme A/metabolism, Animal, Animals, Bile Acids and Salts/*metabolism, Boehme Shannon, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism, Cholesterol/*metabolism, Department of Integrative Medical Sciences, Francl Jessica M, Hepatology (Baltimore, Md.), Homeostasis/*physiology, Knockout, Li Tiangang, Lipid Metabolism/physiology, Liver/metabolism, Male, Messenger/metabolism, Mice, MicroRNAs/*metabolism, Models, NEOMED College of Medicine, RNA, Signal Transduction/*physiology, Sterol Regulatory Element Binding Protein 2/*metabolism, Transgenic
Coordinate down-regulation of cartilage matrix gene expression in Bcl-2 deficient chondrocytes is associated with decreased SOX9 expression and decreased mRNA stability.
Tags: 2003, Aggrecans, Animals, C-Type, Cell Line, Chondrocytes/*physiology, Collagen Type II/genetics/metabolism, Dactinomycin, Down-Regulation, Extracellular Matrix Proteins/analysis/genetics/*metabolism, Gene Expression Regulation, Glycoproteins/analysis/genetics/*metabolism, High Mobility Group Proteins/genetics/*metabolism, Horton Walter E Jr, Journal of cellular biochemistry, Kinkel Mary D, Lectins, Matrilin Proteins, Messenger/analysis/biosynthesis, Polymerase Chain Reaction/methods, Proteoglycans/genetics/metabolism, Proto-Oncogene Proteins c-bcl-2/deficiency/genetics/*physiology, Rats, RNA, RNA Stability, Signal Transduction, SOX9 Transcription Factor, Transcription Factors/genetics/*metabolism, Transfection
Developmental changes in levels of growth hormone mRNA in Zucker rats.
Tags: 1990, Aging/*metabolism, Ahmad I, Animals, Blotting, Carrillo A J, Finkelstein J A, Glyceraldehyde-3-Phosphate Dehydrogenases/genetics, Growth Hormone/blood/*genetics, Immunoblotting, Journal of cellular biochemistry, Male, Messenger/*metabolism, Northern, Obesity/*genetics, Prolactin/genetics, Rats, RNA, Steggles A W, Zucker
Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.
Tags: *Cell Movement, 2016, Arosarena Oneida A, Barr Eric W, Bryant Evan, Carcinoma, Cell Adhesion, Cell Line, Cell Proliferation, Cell Survival, Dela Cadena Raul A, Denny Michael F, Department of Anatomy & Neurobiology, Enzyme Activation, Gene Expression Regulation, Head and Neck Neoplasms/genetics/*metabolism/pathology, Humans, Integrin beta1/metabolism, Journal of cellular physiology, Membrane Glycoproteins/genetics/*metabolism, Messenger/metabolism, Mitogen-Activated Protein Kinases/metabolism, Mouth Neoplasms/genetics/*metabolism/pathology, NEOMED College of Medicine, Neoplasm Invasiveness, Neoplastic, Protein Binding, RNA, RNA Interference, Safadi Fayez F, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/genetics/*metabolism/pathology, Thorpe Ryan, Time Factors, Transfection, Tumor
Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Tags: *Cell Movement, 2018, Arosarena Oneida A, Barr Eric W, Carcinoma, Cell Line, cell lines, Department of Anatomy & Neurobiology, Enzymologic, Extracellular Matrix, Gene Expression Regulation, Head and Neck Neoplasms/*enzymology/genetics/pathology, Human, Humans, Journal of cellular physiology, matrix metalloproteinases, Membrane Glycoproteins/genetics/*metabolism, Messenger/genetics/metabolism, NEOMED College of Medicine, neoplasm invasion, Neoplasm Invasiveness, Neoplastic, RNA, RNA Interference, Safadi Fayez F, Secreted/genetics/*metabolism, Signal Transduction, Squamous Cell Carcinoma of Head and Neck, Squamous Cell/*enzymology/genetics/pathology, Tarr Joseph T, Thorpe Ryan, Transfection, Tumor, Yankey Hilary
Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition.
Tags: 2007, Animals, Cervix Uteri/*innervation, Department of Anatomy & Neurobiology, Excitatory Amino Acid Antagonists/pharmacology, Female, Ganglia, Gene Expression Regulation/drug effects/*physiology, Ghosh Chaitali, Glutamates/*metabolism, Hafemeister Jen, Journal of neuroscience research, Lumbosacral Region, Messenger/biosynthesis, Metabotropic Glutamate 5, Metabotropic Glutamate/*metabolism, Miller Kenneth E, NEOMED College of Medicine, Neurons/drug effects, Oncogene Proteins v-fos/metabolism, Papka Raymond E, Parturition/*metabolism, Pregnancy/*metabolism, Pyridines/pharmacology, Rats, Receptor, Receptors, Reverse Transcriptase Polymerase Chain Reaction/methods, RNA, Spinal Cord/drug effects/*physiology, Spinal/cytology, Sprague-Dawley, Storey-Workley Megan, Usip Sharon, Vesicular Glutamate Transport Protein 1/metabolism
Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).
Tags: 1993, Amino Acid, Amino Acid Sequence, Animals, Archives of biochemistry and biophysics, Base Sequence, Blotting, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Cloning, Crestani M, Cricetinae, Department of Integrative Medical Sciences, DNA/genetics/isolation & purification, Galli G, Genomic Library, Humans, Liver/enzymology, Mesocricetus/*genetics, Messenger/biosynthesis/metabolism, Molecular, Molecular Sequence Data, NEOMED College of Medicine, Northern, Poly A/biosynthesis/metabolism, Rats, Restriction Mapping, RNA, Sequence Homology, Southern
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells.
Tags: 1994, Animals, Bile Acids and Salts/*pharmacology, Biochemical and biophysical research communications, Cells, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, Crestani M, Cultured, Department of Integrative Medical Sciences, Enzymologic/*drug effects, Gene Expression Regulation, Genetic, Genetic/genetics, Humans, Karam W G, Luciferases/biosynthesis/genetics, Messenger/*biosynthesis, NEOMED College of Medicine, Promoter Regions, Rats, Recombinant Fusion Proteins/biosynthesis, RNA, Steroids/*pharmacology, Thyroid Hormones/*pharmacology, Transcription, Transfection
The isolation and characterization of the human cytochrome b5 gene.
Tags: 1995, Animals, Base Sequence, Biochemical and biophysical research communications, Cattle, Cell Line, Cloning, Cosmids, Cultured, Cytochromes b5/biosynthesis/*genetics, DNA Primers, DNA/genetics/isolation & purification, Gene Library, Genetic, Giordano S J, Hominidae/*genetics, Humans, Introns, Li X R, Luciferases/biosynthesis, Messenger/analysis/biosynthesis, Molecular, Molecular Sequence Data, Polymerase Chain Reaction, Promoter Regions, Rabbits, RNA, Steggles A W, Transfection, Tumor Cells, Yoo M
Binding of sequence-specific proteins to the 3'-untranslated region of vasoactive intestinal peptide mRNA.
Tags: 1995, Animals, Anterior/*metabolism, Base Sequence, Binding, Biochemical and biophysical research communications, Competitive, Cytoplasm/chemistry, Gene Expression Regulation, Genomic Library, Male, Messenger/*metabolism, Molecular Sequence Data, Pituitary Gland, Post-Transcriptional, Protein Binding, Proto-Oncogene Proteins c-fos/genetics, Rats, RNA, RNA Processing, RNA-Binding Proteins/*metabolism, RNA/metabolism, Signs S A, Sprague-Dawley, Subcellular Fractions, Tissue Distribution, Vasoactive Intestinal Peptide/*genetics, Wolford J K
The isolation and characterization of the bovine cytochrome b5 gene, and a transcribed pseudogene.
Tags: *Pseudogenes, 1993, Amino Acid Sequence, Animals, Base Sequence, Blotting, Cattle/*genetics, Cristiano R J, Cytochromes b5/*genetics, DNA/genetics/isolation & purification, Exons, Gene Expression, Genetic, Genomic Library, Genomics, Giordano S J, Humans, Introns, Messenger/biosynthesis/metabolism, Molecular Sequence Data, Nucleic Acid, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Rabbits, Restriction Mapping, Reticulocytes/metabolism, RNA, RNA Precursors/chemistry/metabolism, Sequence Homology, Southern, Steggles A W, Transcription
The antiviral activity of RNA-dye combinations.
A splicing mutation in the cytochrome b5 gene from a patient with congenital methemoglobinemia and pseudohermaphrodism.
Tags: *DNA, *Mutation, 1994, Base Sequence, Cytochromes b5/*genetics, Disorders of Sex Development/*enzymology/genetics, DNA Primers/chemistry, Gene Deletion, Giordano S J, Human genetics, Humans, Kaftory A, Leukocytes/metabolism, Male, Messenger/metabolism, Methemoglobinemia/*congenital/*enzymology, Molecular Sequence Data, Polymerase Chain Reaction, Recombinant, Reticulocytes/metabolism, RNA, Steggles A W
Induction of ethanol dependence increases signal peptidase mRNA levels in rat brain.
Tags: *Membrane Proteins, *Serine Endopeptidases, 1994, Alcoholism/*enzymology, Amino Acid, Amino Acid Sequence, Animals, Base Sequence, Blotting, Brain/*enzymology, Complementary, DNA, Endopeptidases/*biosynthesis/chemistry/genetics, Ethanol/*pharmacology, Jacquet R, Male, Messenger/genetics/metabolism, Molecular and cellular biochemistry, Molecular Sequence Data, Northern, Nucleic Acid, Rats, RNA, Sequence Homology, Signs S A, Sprague-Dawley, Substance Withdrawal Syndrome/enzymology
The large protein 'L' of Peste-des-petits-ruminants virus exhibits RNA triphosphatase activity, the first enzyme in mRNA capping pathway.
Tags: 2019, Acid Anhydride Hydrolases/*metabolism, Animals, Ansari Mohammad Yunus, Baculoviridae/genetics, Bellur Asutosh, Cercopithecus aethiops, Cloning, Conventional mRNA capping, Department of Anatomy & Neurobiology, Enzyme Activation, Gene Expression, Genetic Vectors/genetics, Messenger/*genetics/*metabolism, Molecular, Morbillivirus, mRNA capping, NEOMED College of Medicine, Peste-des-petits-ruminants virus L protein, Peste-des-petits-ruminants virus/*physiology, Peste-des-Petits-Ruminants/*virology, PPRV, Rajagopalan Deepa, RNA, RNA Caps/*metabolism, RNA triphosphatase, Shaila Melkote Subbarao, Shanmugam Purnima, Singh Piyush Kumar, Vero Cells, Viral Proteins/*metabolism, Virus Genes
Differential expression of the mRNAs for the soluble and membrane-bound forms of rabbit cytochrome b5.
Tags: 1993, Agar Gel, Amino Acid Sequence, Animals, Base Sequence, Biochimica et biophysica acta, Blotting, Cell Membrane/metabolism, Cytochromes b5/*genetics, Cytosol/metabolism, DNA/genetics/isolation & purification, Electrophoresis, Exons, Giordano S J, Leukocytes/metabolism, Liver/*metabolism, Messenger/genetics/isolation & purification/*metabolism, Molecular Sequence Data, Oligodeoxyribonucleotides, Polymerase Chain Reaction/methods, Rabbits, Reticulocytes/metabolism, RNA, Southern, Steggles A W
Para-chlorophenylalanine treatment inhibits the expression of vasoactive intestinal peptide messenger RNA in rat anterior pituitary.
Tags: 1993, alpha-Methyltyrosine, Animals, Anterior/*drug effects/metabolism, Brain research. Molecular brain research, Carrillo A J, Chemical, Depression, Dluzen D E, Dopamine/metabolism, Fenclonine/*pharmacology, Gene Expression Regulation/drug effects, Male, Messenger/*biosynthesis, Methyltyrosines/pharmacology, Pituitary Gland, Prolactin/metabolism, Rats, RNA, Serotonin/metabolism, Signs S A, Sprague-Dawley, Tryptophan Hydroxylase/antagonists & inhibitors, Vasoactive Intestinal Peptide/*biosynthesis/genetics
Serotonergic involvement in the regulation of prolactin and vasoactive intestinal peptide mRNA expression in the rat anterior pituitary.
Tags: 1994, 5-Hydroxytryptophan/pharmacology, alpha-Methyltyrosine, Animals, Anterior/*chemistry/drug effects/metabolism, Blotting, Bromocriptine/pharmacology, Carrillo A J, Gene Expression Regulation/drug effects/physiology, Genetic, Haloperidol/pharmacology, Ketanserin/pharmacology, Liu B, Male, Messenger/*analysis/genetics, Methiothepin/pharmacology, Methoxydimethyltryptamines/pharmacology, Methyltyrosines/pharmacology, Molecular and cellular endocrinology, Northern, Pituitary Gland, Prolactin/analysis/*genetics/metabolism, Quipazine/pharmacology, Rats, RNA, Serotonin/*physiology, Signs S A, Sprague-Dawley, Time Factors, Transcription, Vasoactive Intestinal Peptide/analysis/*genetics/metabolism, Wolford J
Expression of alpha-cardiac myosin heavy chain in normal and denervated rat muscle spindles.
Analysis of connective tissues by laser capture microdissection and reverse transcriptase-polymerase chain reaction.
Tags: *Microdissection, 2005, Analytical biochemistry, Animals, Cell Separation/*methods, Chondrocytes/chemistry/cytology, Connective Tissue Cells/chemistry/*cytology, Gene Expression Profiling/*methods, Growth Plate/cytology, Hillyer Jennifer, Inbred Strains, Jacquet Robin, Landis William J, Lasers, Messenger/analysis/*isolation & purification, Methods, Mice, Newborn, Reverse Transcriptase Polymerase Chain Reaction, RNA, Tibia/cytology
An effective and efficient method of transfecting primary human chondrocytes in suspension.
Tags: *CHONDROCYTES, *OSTEOARTHRITIS, *siRNA, *Transfection, 2017, Aggrecans/genetics, Akhtar Nahid, Analytical biochemistry, Articular/metabolism/pathology, Cartilage, Cells, Chondrocytes/cytology/*metabolism, Collagen Type II/genetics, Cultured, Department of Anatomy & Neurobiology, Haqqi Tariq M, Humans, Makki Mohammad Shahidul, Messenger/*genetics, mRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors/genetics, NEOMED College of Medicine, Nucleotidyltransferases/antagonists & inhibitors/genetics, Plasmids/*genetics, RNA, Small Interfering/*genetics, Transfection/*methods
Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells.
Tags: 2006, Animals, Antiviral Agents/*pharmacology, Antiviral research, Bailey Erin, Booth Tristan, Cell Nucleus/chemistry, Cercopithecus aethiops, Cytoplasm/chemistry, DNA, Docherty John J, Electrophoretic Mobility Shift Assay, Faith Seth A, Fluorescence, Herpesvirus 1, Herpesvirus 2, Human/drug effects/genetics/*growth & development, Human/drug effects/genetics/*physiology, I-kappa B Proteins/metabolism, Messenger/biosynthesis, Microscopy, NF-kappa B/*metabolism, NF-KappaB Inhibitor alpha, Polymerase Chain Reaction, Resveratrol, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stilbenes/*pharmacology, Sweet Thomas J, Transcription Factor RelA/metabolism, Vero Cells, Viral/biosynthesis, Virus Replication/*drug effects
Resveratrol inhibition of varicella-zoster virus replication in vitro.
Tags: 2006, Antiviral Agents/*pharmacology, Antiviral research, Bailey Erin, Blotting, Booth Tristan, Cell Line, Docherty John J, Dose-Response Relationship, Drug, Faith Seth A, Fibroblasts/virology, Herpesvirus 3, Human/*drug effects/physiology, Humans, Immediate-Early Proteins/biosynthesis, Messenger/biosynthesis, Resveratrol, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stilbenes/*pharmacology, Sweet Thomas J, Trans-Activators/biosynthesis, Viral Envelope Proteins/biosynthesis, Viral Plaque Assay, Viral/biosynthesis, Virus Attachment/drug effects, Virus Inactivation/drug effects, Virus Replication/*drug effects, Western
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice.
Tags: 2009, Adenoviridae/genetics, Animals, Bile Acids and Salts/biosynthesis, Biochimica et biophysica acta, Cell Line, Cell Nucleus/drug effects/metabolism, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/*antagonists & inhibitors/genetics/metabolism, Department of Integrative Medical Sciences, Dietary Fats/*administration & dosage/*pharmacology, Down-Regulation/drug effects, Enzymologic/drug effects, Feeding Behavior/*drug effects, Forkhead Box Protein O1, Forkhead Transcription Factors/genetics/*metabolism, Gene Expression Regulation, Gene Knockdown Techniques, Gene Transfer Techniques, Hepatocytes/drug effects/*enzymology, Humans, Inbred C57BL, Insulin Resistance, Insulin/metabolism, Lee Yoon-Kwang, Li Tiangang, Ma Huiyan, Male, Messenger/genetics/metabolism, Mice, Moore David D, NEOMED College of Medicine, Park Young Joo, RNA, RNA Interference/drug effects, Strom Stephen, Tumor
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Tags: 2009, Animals, Biochemical pharmacology, Bourque Melanie, Corpus Striatum/*metabolism, Di Paolo Therese, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins/*genetics, Female, Ji Jing, Male, Messenger/biosynthesis, Mice, Mutant Strains, Protein Binding, Reserpine/pharmacology, RNA, Sex Characteristics, Substantia Nigra/*metabolism, Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus.
Tags: 2005, 3' Untranslated Regions/genetics, Amino Acid, Animals, Antisense/*genetics/isolation & purification/*metabolism, Brain research. Molecular brain research, Conserved Sequence/genetics, DNA-Binding Proteins/genetics/*metabolism, Gainer Harold, Gene Expression Regulation/*genetics, Genetic/genetics, Genomic Imprinting/genetics, Glasgow Eric, Hypothalamo-Hypophyseal System/cytology/metabolism, Kruppel-Like Transcription Factors, Male, Messenger/genetics/metabolism, Molecular Sequence Data, Mutsuga Noriko, Neurons/*metabolism, Nucleic Acid, Protein Kinases/genetics/*metabolism, Rats, RNA, Ryu Seung-Lim, Sequence Homology, Sprague-Dawley, Supraoptic Nucleus/cytology/*metabolism, Transcription, Transcription Factors/genetics/*metabolism, Vasopressins/*metabolism, Water-Electrolyte Balance/genetics, Yamashita Mitsuo, Zhang Bing-Jun
Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide.
Tags: 2017, Alam Gelerah, Animals, Astrocytes/immunology/pathology, Beier Eric E, Cell Death/physiology, Corpus Striatum/immunology/pathology, Cytokines/metabolism, Department of Pharmaceutical Sciences, Disease Progression, Dopaminergic Neurons/*immunology/pathology, Edler Melissa, Inbred C57BL, Inflammation/pathology/physiopathology, Lipopolysaccharides/*toxicity, Male, Messenger/metabolism, Mice, Microglia/*immunology/pathology, Neal Matthew, NEOMED College of Pharmacy, Nerve Degeneration/*immunology/pathology, Neurobiology of disease, Neurodegenerative Diseases/immunology/pathology, Neuroimmunomodulation/physiology, Random Allocation, Richardson Jason R, RNA, Time Factors, Wu Long-Jun
Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression.
Tags: 2017, Animals, BDNF, Brain-Derived Neurotrophic Factor/metabolism, Cerebral Cortex/*drug effects/growth & development/metabolism, Corpus Striatum/*drug effects/growth & development/metabolism, Deltamethrin, Department of Pharmaceutical Sciences, Female, Inbred C57BL, Insecticides/*toxicity, Magby Jason P, Male, Messenger/metabolism, Mice, NEOMED College of Pharmacy, Neurodevelopmental, Neurons/*drug effects/metabolism, Neurotoxicology, Nitriles/*toxicity, Pregnancy, Prenatal Exposure Delayed Effects/*metabolism, Pyrethrins/*toxicity, Pyrethroid, Richardson Jason R, RNA, Sodium channel, Voltage-Gated Sodium Channels/*metabolism
Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Tags: 2017, Acetylation/drug effects, Animals, Butyrates/pharmacology, Cell Line, Cell Survival/drug effects, Department of Pharmaceutical Sciences, Dopamine Plasma Membrane Transport Proteins/*metabolism, Dopamine transporter, Dopaminergic Neurons/cytology/drug effects/metabolism, Dose-Response Relationship, Drug, Eid Aseel, Epigenesis, Epigenetics, Genetic, Genetic/drug effects, Green Ashley L, Group A, Guo Grace L, HDAC, Histone deacetylase, Histone Deacetylase Inhibitors/*pharmacology, Histone Deacetylases/metabolism, Histones/*drug effects/metabolism, Homeodomain Proteins/metabolism, Hydroxamic Acids/pharmacology, Member 2/*metabolism, Messenger/metabolism, NEOMED College of Pharmacy, Neuropharmacology, Nuclear Receptor Subfamily 4, Nurr1, Pitx3, Promoter Regions, Rats, Richardson Jason R, RNA, Transcription Factors/metabolism, Valproate, Valproic Acid/*pharmacology, Zarbl Helmut, Zhan Le
Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target.
Tags: 2013, Animal, Animals, Astrocytes/*metabolism, Axonal Transport/*physiology, Balaram P, Brain-Derived Neurotrophic Factor/*metabolism, Calkins D J, Crish S D, Dapper J D, Department of Pharmaceutical Sciences, Disease Models, Glaucoma/genetics/*metabolism, Lambert W S, MacNamee S E, Messenger/genetics/metabolism, Mice, NEOMED College of Pharmacy, Neuroscience, Optic Nerve Diseases/genetics/metabolism, Rats, Retinal Ganglion Cells/*metabolism, RNA, Sidorova T N, Superior Colliculi/metabolism, Synapses/*metabolism, Visual Pathways/metabolism
Inhibition of cartilage degradation and suppression of PGE2 and MMPs expression by pomegranate fruit extract in a model of posttraumatic osteoarthritis.
Tags: *Phytotherapy, *Punicaceae, 2017, ACLT, Akhtar Nahid, Animal, Animals, Anterior Cruciate Ligament/drug effects/metabolism/pathology, Apoptosis, Ashruf Omer S, Cartilage/cytology/*drug effects/metabolism/pathology, Chondrocytes/drug effects/metabolism/pathology, Collagen Type II/genetics/metabolism, Department of Anatomy & Neurobiology, Dinoprostone/*metabolism, Disease Models, Disease Progression, Female, Fruit, Haqqi Tariq M, Interleukins/metabolism, Joints/cytology/*drug effects/metabolism/pathology, Khan Nazir M, Male, Messenger/metabolism, Metalloproteases/genetics/*metabolism, Mitogen-Activated Protein Kinases/metabolism, MMPs, NEOMED College of Medicine, NF-kappa B/metabolism, Nutrition (Burbank, Los Angeles County, Calif.), Osteoarthritis, Osteoarthritis/*drug therapy/etiology/metabolism/pathology, PGE(2), Plant Extracts/pharmacology/therapeutic use, Pomegranate, Rabbit, Rabbits, RNA, Synovial Fluid/metabolism
Intrajoint comparisons of gene expression patterns in human osteoarthritis suggest a change in chondrocyte phenotype.
Tags: *Gene Expression Profiling, 2005, 80 and over, Aged, Articular/*metabolism, Cartilage, Chondrocytes/*metabolism, Collagen Type II/genetics, Department of Anatomy & Neurobiology, Glycosaminoglycans/analysis, High Mobility Group Proteins/genetics, Horton Walter E Jr, Humans, Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Laverty David, Matrix Metalloproteinase 3/genetics, Matrix Metalloproteinase 9/genetics, McBurney Denise, Messenger/analysis, NEOMED College of Medicine, Osteoarthritis/*metabolism, Phenotype, Proto-Oncogene Proteins c-bcl-2/genetics, RNA, SOX9 Transcription Factor, Transcription Factors/genetics, Weiner Scott, Yagi Rieko
The effects of pregnancy and estrogen on the expression of calcitonin gene-related peptide (CGRP) in the uterine cervix, dorsal root ganglia and spinal cord.
Tags: 2003, Animals, Calcitonin Gene-Related Peptide/analysis/biosynthesis/*genetics, Cervix Uteri/*physiology, Collins J, Department of Anatomy & Neurobiology, Estrogens/*physiology, Female, Ganglia, Hargreaves K M, Immunohistochemistry, In Situ Hybridization, Messenger/metabolism, Mowa C N, NEOMED College of Medicine, Papka R E, Peptides, Pregnancy, Radioimmunoassay, Rats, RNA, Spinal Cord/*physiology, Spinal/*physiology, Sprague-Dawley, Storey-Workley M, Usip S
Expression of pituitary adenylate cyclase activating peptide in the uterine cervix, lumbosacral dorsal root ganglia and spinal cord of rats during pregnancy.
Tags: *Gene Expression Regulation, 2006, Animals, Cervix Uteri/*metabolism, Department of Anatomy & Neurobiology, Fahrenkrug J, Female, Ganglia, Messenger, Mowa C N, NEOMED College of Medicine, Papka R E, Peptides, Pituitary Adenylate Cyclase-Activating Polypeptide/*genetics/*metabolism, Pregnancy, Rats, RNA, Spinal Cord/*metabolism, Spinal/*metabolism, Time Factors, Usip S, Workley M
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals.
Tags: *Calcium Signaling, *Cell Differentiation, *Mechanotransduction, 2013, Adapala Ravi K, Animals, Cellular, Chilian William M, Department of Integrative Medical Sciences, Extracellular Matrix/metabolism/physiology, Fibroblasts/*physiology, Gene Knockdown Techniques, Journal of molecular and cellular cardiology, Luther Daniel J, Male, Meszaros J Gary, Monoterpenes/pharmacology, Myocardium/cytology, Myofibroblasts/metabolism, NEOMED College of Medicine, Paruchuri Sailaja, Rats, RNA, Small Interfering/genetics, Sprague-Dawley, Thodeti Charles K, Thoppil Roslin J, Transforming Growth Factor beta1/physiology, TRPM Cation Channels/antagonists & inhibitors/metabolism, TRPV Cation Channels/genetics/*metabolism
Ultrastructural nucleolar alterations induced by an ametantrone–poly r(A-U) complex.
Tags: 1998, Antineoplastic Agents/*pharmacology, Authelet M, Carcinoma, Cell Nucleolus/*chemistry/drug effects/ultrastructure, Cultured/chemistry/drug effects/ultrastructure, DNA, Gilloteaux J, Goessens G, Humans, Immunoelectron, Jamison J M, Microscopy, Mitoxantrone/*analogs & derivatives/pharmacology, Neoplasm/*analysis, Neoplasm/analysis, Poly A-U/*pharmacology, Ribosomal/analysis, Ribosomal/analysis/ultrastructure, RNA, Summers J L, Thiry M, Tissue & cell, Transitional Cell, Tumor Cells, Urinary Bladder Neoplasms