Management of solitary and multiple brain metastases from breast cancer.
breast cancer; Brain metastasis; gamma knife; radiosurgery; whole brain radiation
As local and systemic control of breast cancer improves, metastasis to the brain remains a common event requiring a specialized management approach. Women diagnosed with breast cancer who develop brain metastases have superior overall survival compared to patients with other forms of metastatic carcinoma. This article summarizes some of the unique aspects of care for patients with breast cancer metastases to the brain.
Willett Addison; Wilkinson J Ben; Shah Chirag; Mehta Minesh P
Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology
2015
2015-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.4103/0971-5851.158835" target="_blank" rel="noreferrer noopener">10.4103/0971-5851.158835</a>
Malignant peripheral nerve sheath tumor at the cerebellopontine angle treated with Gamma Knife radiosurgery: case report and review of the literature.
Cerebellopontine angle; Gamma Knife; Malignant peripheral nerve sheath tumor; Radiosurgery; Skull base; Stereotaxy
BACKGROUND AND IMPORTANCE: Malignant peripheral nerve sheath tumor (MPNST) is a rare lesion that may arise de novo or develop from an existing benign neurofibroma. Very rarely, MPNST may develop from an existing schwannoma. Intracranial MPNST is rare, and most commonly affects thevestibulocochlear nerve. Surgery is the mainstay of treatment for these lesions, but gross total resection is often difficult given the proximity of adjacent neurovascular structures. Gamma knife radiosurgery (GKS) may represent a useful adjunct to subtotal resection or biopsy of these lesions, but its use for this tumor type has not been well defined. CLINICAL PRESENTATION: The patient, who had a long history of progressive sub-clinical hearing loss, presented with facial droop and decreased facial sensation. Imaging revealed a large left cerebellopontine angle tumor extending into the internal auditory canal. The mass was subtotally resected, and pathology revealed a malignant peripheral nerve sheath tumor. The patient underwent fractionated external beam radiotherapy two months later to the resection cavity, followed by Gamma Knife radiosurgery (GKRS) to the residual tumor. Follow up imaging eight months after GKRS revealed a substantial reduction in tumor size. The patient has remained clinically stable. CONCLUSION: GKS may be a useful adjunct to multimodality treatment for malignant tumors of the CPA, such as MPNST, after subtotal resection and/or radiotherapy. Close ongoing follow up with periodic MR imaging is essential to monitor for recurrence.
Raper Daniel M S; Sweiss Fadi; Almira-Suarez M Isabel; Helm Gregory; Sheehan Jason P
Journal of radiosurgery and SBRT
2013
2013
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).