1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0196-9781(03)00064-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0196-9781(03)00064-0</a>
Pages
469–475
Issue
3
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Tachykinin peptide-induced activation and desensitization of neurokinin 1 receptors.
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-03
Subject
The topic of the resource
Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Down-Regulation/*drug effects; Electrophysiology; Ligands; Neurokinin-1/*agonists/*metabolism; Potassium/metabolism; Protein Binding; Rana catesbeiana; Receptors; Tachykinins/chemistry/*pharmacology
Creator
An entity primarily responsible for making the resource
Perrine S A; Bennett V J; Simmons M A
Description
An account of the resource
The actions of four tachykinins on inhibition and desensitization of the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0196-9781(03)00064-0" target="_blank" rel="noreferrer noopener">10.1016/s0196-9781(03)00064-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
Amino Acid Sequence
Animals
Bennett V J
CHO Cells
Cricetinae
Down-Regulation/*drug effects
Electrophysiology
Ligands
Neurokinin-1/*agonists/*metabolism
Peptides
Perrine S A
Potassium/metabolism
Protein Binding
Rana catesbeiana
Receptors
Simmons M A
Tachykinins/chemistry/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/jpet.106.109512" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/jpet.106.109512</a>
Pages
907–913
Issue
2
Volume
319
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Functional selectivity of NK1 receptor signaling: peptide agonists can preferentially produce receptor activation or desensitization.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-11
Subject
The topic of the resource
Animals; CHO Cells; Cricetinae; Dose-Response Relationship; Drug; Humans; Neurokinin-1/agonists/drug effects/*physiology; Rana catesbeiana; Rats; Receptors; Signal Transduction/*physiology; Substance P/metabolism/pharmacology; Tachykinins/metabolism/pharmacology
Creator
An entity primarily responsible for making the resource
Simmons Mark A
Description
An account of the resource
A cascade of events follows binding of an agonist ligand to the tachykinin NK(1) receptor. These events include activation of multiple signal transduction pathways as well as cellular modulation of receptor function by the process of desensitization. This study examines the differences in the abilities of naturally occurring peptide agonist ligands of the tachykinin NK(1) receptor to preferentially direct signaling through the receptor to produce signal activation versus receptor desensitization. The differential effects of tachykinin peptides with respect to ligand competition binding, receptor-G protein coupling, intracellular Ca(2+) elevations, and receptor desensitization have been measured. In relation to its potency in competition binding studies, substance P produces desensitization at lower concentrations, whereas higher concentrations are required to elicit a Ca(2+) response. In contrast to this, a related peptide, ranatachykinin C, is more effective at activating a Ca(2+) response relative to its ability to produce desensitization. This difference in functional selectivity is conserved for an amphibian and two mammalian ortholog tachykinin receptors. The present study demonstrates that peptide agonist ligands of NK(1) receptors can preferentially produce signal activation or desensitization.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/jpet.106.109512" target="_blank" rel="noreferrer noopener">10.1124/jpet.106.109512</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Animals
CHO Cells
Cricetinae
Dose-Response Relationship
Drug
Humans
Neurokinin-1/agonists/drug effects/*physiology
Rana catesbeiana
Rats
Receptors
Signal Transduction/*physiology
Simmons Mark A
Substance P/metabolism/pharmacology
Tachykinins/metabolism/pharmacology
The Journal of pharmacology and experimental therapeutics