Browse Items · NEOMED Bibliography Database

Efficacy and Safety of Intravenous-to-oral Lefamulin, a Pleuromutilin Antibiotic, for the Treatment of Community-acquired Bacterial Pneumonia: The Phase III Lefamulin Evaluation Against Pneumonia (LEAP 1) Trial.

BACKGROUND: Lefamulin, a pleuromutilin antibiotic, is active against pathogens commonly causing community-acquired bacterial pneumonia (CABP). The Lefamulin Evaluation Against Pneumonia (LEAP 1) study was a global noninferiority trial to evaluate…

Tags: 2019, Administration Intravenous, Adult, Aged, Anti-Bacterial Agents/administration & dosage/adverse effects/therapeutic use, antibiotic, Clinical Infectious Diseases, Das A, Diterpenes/administration & dosage/adverse effects/therapeutic use, Double-Blind Method, Female, File TM, Gasink LB, Gelone SP, Goldberg L, Hospital List, Humans, journalArticle, lefamulin, Linezolid/adverse effects/therapeutic use, Male, Microbial Sensitivity Tests, Middle Aged, Moxifloxacin, Moxifloxacin/administration & dosage/adverse effects/therapeutic use, Paukner S, pleuromutilin, Pneumonia, Pneumonia Bacterial/drug therapy/metabolism, Polycyclic Compounds/administration & dosage/adverse effects/therapeutic use, Randomized Controlled Trials as Topic, Saviski J, Seltzer E, Sweeney C, Talbot GH, Thioglycolates/administration & dosage/adverse effects/therapeutic use, Wicha WW

Outcomes with drug-coated balloons in small-vessel coronary artery disease.

BACKGROUND: Percutaneous coronary intervention (PCI) of small-vessel coronary artery disease (SVD) is associated with increased risk of restenosis. The use of drug-coated balloons (DCBs) in SVD has received limited study. OBJECTIVES: To assess the…

Tags: 2019, Abbott JD, Aged, Angioplasty Balloon Coronary/adverse effects/instrumentation/mortality, Brilakis ES, Cardiac Catheters, Cardiovascular Agents/administration & dosage/adverse effects, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Cleveland Clinic Akron General Hospital, Coated Materials Biocompatible, Coronary Artery Disease/diagnostic imaging/mortality/therapy, Coronary Restenosis/epidemiology, Department of Internal Medicine, drug-coated balloons, drug-eluting balloons, Drug-Eluting Stents, Female, Humans, journalArticle, June2020SubmittedList, Kalra A, Kohl LP, Male, Megaly M, Middle Aged, NEOMED College of Medicine, Observational Studies as Topic, Randomized Controlled Trials as Topic, Rezq A, Risk Assessment, Risk Factors, Rofael M, Saad M, Shishehbor M, small-vessel disease coronary disease, Soukas P, Treatment Outcome

Neoadjuvant chemotherapy for operable breast cancer: is this the future?

The idea of using preoperative or neoadjuvant chemotherapy in patients with operable breast cancer originated from experimental and clinical observations as well as theoretical hypotheses on tumor cell growth and dissemination. Initially,…

Common fungal infections of the feet in patients with diabetes mellitus.

Superficial fungal infections of the foot (tinea pedis and onychomycosis) are common among elderly patients. Although most authorities believe that patients with diabetes mellitus have an increased predisposition to dermatophytic infections, some…

Tags: *Diabetes Complications, *Onychomycosis/diagnosis/drug therapy/physiopathology, *Tinea Pedis/diagnosis/drug therapy/physiopathology, 2004, Aged, Antifungal Agents/adverse effects/pharmacokinetics/*therapeutic use, Arthrodermataceae/*pathogenicity, Biological Availability, Diabetes Mellitus/drug therapy, Drug Interactions, Drugs & aging, Humans, Hypoglycemic Agents/therapeutic use, Joseph Warren S, Metabolic Clearance Rate, Randomized Controlled Trials as Topic, Tan James S

Is combination therapy for carbapenem-resistant Klebsiella pneumoniae the new standard of care?

Carbapenem-resistant Klebsiella pneumoniae causes serious nosocomial infections and therapeutic options are limited. There is increasing evidence suggesting that combination antibiotic therapy is more effective than monotherapy and leads to better…

Tags: 2015, Anti-Bacterial Agents/*therapeutic use, beta-Lactam Resistance/genetics, carbapenem-resistant Klebsiella pneumoniae, Carbapenems/*therapeutic use, combination antibiotic therapy, Combination/*statistics & numerical data, Department of Internal Medicine, Deresinski Stan, Drug Therapy, Expert review of anti-infective therapy, Humans, Klebsiella Infections/*drug therapy/microbiology, Klebsiella pneumoniae/*drug effects/genetics/pathogenicity, NEOMED College of Medicine, Randomized Controlled Trials as Topic, Watkins Richard R

A Review of Treatment for Breast Cancer-Related Lymphedema: Paradigms for Clinical Practice.

OBJECTIVES: Breast cancer-related lymphedema (BCRL) represents a major complication of breast cancer treatment, impacting the quality of life for breast cancer survivors that develop it. The purpose of this review is to evaluate the literature…

The effect of race on outcomes of surgical or nonsurgical treatment of patients in the Spine Patient Outcomes Research Trial (SPORT).

STUDY DESIGN: Retrospective review of the data collected prospectively through the Spine Patient Outcomes Research Trial (SPORT). OBJECTIVE: To determine the effect that race or ethnicity had on outcomes after spine surgery in the 3 arms of SPORT.…

Ceftaroline fosamil versus ceftriaxone for the treatment of community-acquired pneumonia: individual patient data meta-analysis of randomized controlled trials.

BACKGROUND: We conducted a meta-analysis of clinical trials of adults hospitalized with pneumonia outcomes research team (PORT) risk class 3-4 community-acquired pneumonia (CAP) receiving ceftaroline fosamil versus ceftriaxone. METHODS: Three Phase…

Remission of nephrotic syndrome in type 1 diabetes: long-term follow-up of patients in the Captopril Study.

In 1994, we reported a 3.4 +/- 0.8 year follow-up of the eight patients who experienced remission of nephrotic syndrome during the Collaborative Study Group-sponsored, multicenter trial of captopril therapy in patients with type 1 diabetes with…

Tags: 1999, Adult, American journal of kidney diseases : the official journal of the National Kidney Foundation, Angiotensin-Converting Enzyme Inhibitors/*therapeutic use, Antihypertensive Agents/*therapeutic use, Bain R P, Blood Pressure/drug effects, Blumenthal S, Captopril/*therapeutic use, Cattran D, Chronic/etiology, Creatinine/blood, Department of Internal Medicine, Diabetes Mellitus, Diabetic Nephropathies/*drug therapy/physiopathology, Disease Progression, Female, Follow-Up Studies, Hebert L A, Humans, Kidney Failure, Levey A S, Lewis E J, Lewis J B, Male, Middle Aged, NEOMED College of Medicine, Nephrotic Syndrome/complications/*drug therapy/physiopathology, Prospective Studies, Proteinuria, Randomized Controlled Trials as Topic, Remission Induction, Rohde R D, Spitalewitz S, Type 1/*complications, Whittier F, Wilmer W A

Macrolide therapy for community-acquired pneumonia due to atypical pathogens: outcome assessment at an early time point.

BACKGROUND: Therapy directed against atypical pathogens in patients with community-acquired pneumonia (CAP) is often recommended. This post-hoc analysis evaluated the effect of addition of a macrolide to ceftaroline fosamil or ceftriaxone treatment…

Tags: 2017, 80 and over, Adult, Aged, Anti-Bacterial Agents/adverse effects/*therapeutic use, Atypical pathogen, Bacterial/*drug therapy, Ceftaroline fosamil, Ceftriaxone/adverse effects/*therapeutic use, Cephalosporins/adverse effects/*therapeutic use, Chlamydial Pneumonia, Chlamydophila pneumoniae, Clinical Trials, Combination/adverse effects/methods, Community-Acquired Infections/*drug therapy, Community-acquired pneumonia, Department of Internal Medicine, Double-Blind Method, Drug Therapy, Eckburg Paul B, Female, File Thomas M Jr, Friedland H David, Humans, International journal of antimicrobial agents, Legionella pneumophila, Llorens Lily, Macrolide, Macrolides/adverse effects/*therapeutic use, Male, Middle Aged, Mycoplasma, Mycoplasma pneumoniae, NEOMED College of Medicine, Phase III as Topic, Pneumonia, Randomized Controlled Trials as Topic, Talbot George H, Time Factors, Treatment Outcome

Prediction of cardiac death in patients with a very low ejection fraction after myocardial infarction: a Cardiac Arrhythmia Suppression Trial (CAST) study.

The Cardiac Arrhythmia Suppression Trial (CAST) database was analyzed with a Cox proportional hazards regression model to predict the mortality of patients with very poor left ventricular systolic function (ejection fraction \textless or = .20).…

Browse Items (11 total)