1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.4103/jcrt.JCRT_22_17" target="_blank" rel="noreferrer noopener">http://doi.org/10.4103/jcrt.JCRT_22_17</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 1476-1481 Issue 6 Volume 16 ISSN 0973-1482 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.4103/jcrt.JCRT_22_17" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.4103/jcrt.JCRT_22_17</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number February 2021 List NEOMED College NEOMED College of Medicine NEOMED Department Department of Internal Medicine Affiliated Hospital Aultman Hospital Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Yet another utility for isocitrate dehydrogenase.1: Can it serve as an immunomarker to assess tumor margins in gliomas? Journal Of Cancer Research And Therapeutics Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-12 Subject The topic of the resource Glioma; infiltration; isocitrate dehydrogenase-1; surgical margin Creator An entity primarily responsible for making the resource Rao S;Rajkumar A;Sundaram S;Joyce ME;Duvuru P Description An account of the resource Background: Isocitrate dehydrogenase-1 (IDH1) mutation is now an established early event in gliomagenesis. The ability to detect this mutation by several techniques including immunohistochemistry makes it a significant marker for diagnosing and prognosticating gliomas. This study was done to assess the expression of mutant IDH1 in different grades of gliomas and evaluate its utility in differentiating reactive gliosis from glioma and defining surgical margins of these tumors in the operative specimens. Materials and Methods: A total of fifty cases including equal number of Grade I, II, III, and IV gliomas and gliosis were included in the study. Formalin-fixed, paraffin-embedded tissue sections from these lesions were immunostained with IDH1 and Ki-67 antibody, and percentage of tumor cells that stained positive with these markers was assessed. Results: Grades II, III, and IV showed consistent immunopositivity for IDH1. No immunostaining was noted in Grade I glioma and gliosis. Mean Ki-67 labeling index correlated with grades of gliomas with low activity in Grade I and high activity in Grade IV. Individual tumor cells infiltrating into adjacent normal brain parenchyma also stained positive with IDH1 antibody. Conclusion: Immunostaining for IDH1 mutation can be utilized as a reliable marker in the precise diagnosis of diffuse gliomas and also in objective assessment of surgical margins to differentiate gliomas from gliosis. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.4103/jcrt.JCRT_22_17" target="_blank" rel="noreferrer noopener">10.4103/jcrt.JCRT_22_17</a> Format The file format, physical medium, or dimensions of the resource journalArticle Publisher An entity responsible for making the resource available Journal Of Cancer Research And Therapeutics 2020 Aultman Hospital Department of Internal Medicine Duvuru P February 2021 List Glioma infiltration isocitrate dehydrogenase-1 Journal Of Cancer Research And Therapeutics journalArticle Joyce ME NEOMED College of Medicine Rajkumar A Rao S Sundaram S surgical margin