Browse Items · NEOMED Bibliography Database

A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.

The antinociceptive properties of intrathecally (i.t.) administered [D-Ala2,

Tags: 1989, 5)-, Ala(2)-MePhe(4)-Gly(5)-, Amines – Physiology, Anesthetics – Pharmacodynamics, Anesthetics/*pharmacology, Animals, Biogenic Monoamines/*physiology, Cell Surface – Drug Effects, Cell Surface – Physiology, Crisp T, D-Penicillamine (2, Dose-Response Relationship, Drug, Enkephalin, Enkephalins, Enkephalins – Pharmacodynamics, Enkephalins/*pharmacology, Inbred Strains, Injections, Intraspinal, Male, Naloxone – Pharmacodynamics, Naloxone/pharmacology, Opioid/drug effects/*physiology, Pain, Pain – Metabolism, Pain/*metabolism, Rats, Receptors, Spanos L J, Spinal, Spinal Cord – Drug Effects, Spinal Cord – Metabolism, Spinal Cord – Physiopathology, Spinal Cord/drug effects/metabolism/*physiopathology, Stafinsky J L

A critical period for long-term potentiation in the developing rat visual cortex.

The in vitro rodent visual cortical slice preparation demonstrates a critical period for long-term potentiation (LTP). Current source density (CSD) analysis reveals peak potentiation of both supra-(layers II-III) and infragranular (layers V) layers…

Tags: 1988, Aging, Animals, Brain research, Electric Stimulation, In Vitro Techniques, Neuronal Plasticity, Newborn, Perkins A T 4th, Rats, Teyler T J, Visual Cortex/*growth & development/physiology

A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.

1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted…

A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.

The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist,…

Tags: 1990, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Amphetamines/*pharmacology, Animals, Brain research, Corpus Striatum/*metabolism, Dopamine D2, Dopamine/*metabolism, Dopamine/drug effects, Electrochemistry, Inbred Strains, Male, Pehek E A, Rats, Receptors, Sulpiride/*pharmacology, Yamamoto B K

A novel mechanism of neurokinin-1 receptor resensitization.

Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the…

Tags: 2002, Animals, Bennett V J, Cell Membrane/drug effects/metabolism, CHO Cells, Concanavalin A/pharmacology, Cricetinae, Monensin/pharmacology, Neurokinin-1/*agonists/*metabolism, Perrine S A, Phosphorylation/drug effects, Rats, Receptors, Simmons M A, The Journal of pharmacology and experimental therapeutics

A novel role for Bcl-2 associated-athanogene-1 (Bag-1) in regulation of the endoplasmic reticulum stress response in mammalian chondrocytes.

BAG-1 (Bcl-2 associated athanogene-1) is a multifunctional protein, linking cell proliferation, cell death, protein folding, and cell stress. In vivo, BAG-1 is expressed in growth plate and articular cartilage, and the expression of BAG-1 is…

A rapid and simple HPLC microassay for biogenic amines in discrete brain regions.

A rapid microassay is described for the measurement of biogenic amines using an isocratic HPLC system with electrochemical detection. Catecholamines, indoleamines and their major metabolites were extracted with 150 microliters of perchloric acid from…

Tags: *Brain Chemistry, 1988, Animals, Biogenic Amines/*analysis, Chromatography, Corpus Striatum/analysis, Donzanti B A, High Pressure Liquid/methods, Inbred Strains, Indicators and Reagents, Male, Nucleus Accumbens/analysis, Organ Specificity, Pharmacology, biochemistry, and behavior, Rats, Reference Values, Yamamoto B K

A single restraint stress exposure potentiates analgesia induced by intrathecally administered DAGO.

In rats, restraint exposure potentiates the magnitude and duration of analgesia following both the peripheral and intracerebroventricular administration of several opioid agonists as compared to non-stressed controls. It has been suggested that the…

A slice preparation preserving the callosal projection to contralateral visual cortex.

Due to the curved path they follow, the visual callosal projections to areas OC1 and OC2 of the rat visual cortex have been inaccessible to studies using brain slices. In this paper we describe a new slice preparation in which a curved cutting blade…

Tags: *Synaptic Transmission, 1990, Animals, Berry R L, Corpus Callosum/*physiology, Electrophysiology, Female, In Vitro Techniques, Inbred Strains, Journal of neuroscience methods, Male, Neurology/instrumentation, Nowicky A, Rats, Teyler T J, Visual Cortex/*physiology

A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.

A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric…

Ablation of the hypothalamic arcuate-median eminence region reduces the concentration of vasoactive intestinal peptide in the anterior pituitary gland of male rats.

This study was designed to determine the influence of the hypothalamus on the content of vasoactive intestinal peptide (VIP) in the anterior pituitary. Disruption of the hypothalamic-pituitary connection was performed by ablating the arcuate-median…

Activation and circuitry of uterine-cervix-related neurons in the lumbosacral dorsal root ganglia and spinal cord at parturition.

Stimulation of the uterine cervix at parturition activates neural circuits involving primary sensory nerves and supraspinally projecting neurons of the lumbosacral spinal cord, resulting in output of hypothalamic neurohormones. Dorsal root ganglia…

Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.

Specific behaviors comprising the serotonin syndrome (low body posture, forepaw treading, headweaving) and the autonomic signs of piloerection and salivation were determined and analyzed with locomotor activity in response to MDMA at three doses…

Acute exercise and gender alter cardiac autonomic tonus differently in hypertensive and normotensive rats.

Arterial pressure (AP), heart rate (HR), cardiac sympathetic tonus (ST), and parasympathetic tonus (PT) were determined in spontaneously hypertensive rats (SHR, 8 male and 8 female) and Wistar-Kyoto normotensive rats (WKY, 8 male and 12 female)…

Acute exercise attenuates cardiac autonomic regulation in hypertensive rats.

Dynamic exercise may be used as a safe, therapeutic approach to reduce sympathetic nerve activity at rest and thus may be beneficial for individuals with hypertension. Therefore, we tested the hypothesis that a single bout of mild to moderate dynamic…

Acute exercise enhances nitric oxide modulation of vascular response to phenylephrine.

The influence of the release of endothelium-derived nitric oxide (NO) on the vasoconstrictor response to phenylephrine (PE) was evaluated before and after a single bout of dynamic exercise. Each rat ran on a motor-driven treadmill at

Acute nicotine and phencyclidine increase locomotor activity of the guinea pig with attenuated potencies relative to their effects on rat or mouse.

Behavioral assays of the responses to psychomotor stimulants can be used to model certain aspects of CNS pathologies such as psychosis and addiction. However, species-dependent differences in the effects of neuromodulators in these assays can…

Tags: 2010, Animals, Dizocilpine Maleate/pharmacology, Excitatory Amino Acid Antagonists/pharmacology, Guinea Pigs, Hudzik Thomas J, Locomotion/*drug effects, Mice, Nicotine/*pharmacology, Pharmacology, biochemistry, and behavior, Phencyclidine/*pharmacology, Rats, Simmons Mark A, Werkheiser Jennifer L

Adenosine depresses excitatory but not fast inhibitory synaptic transmission in area CA1 of the rat hippocampus.

The effects of adenosine on inhibitory synaptic transmission in area CA1 were examined using the rat hippocampal slice preparation and intracellular recording. Adenosine did not change fast inhibitory synaptic potentials (IPSPs) but depressed late…

Tags: 1991, 2-Amino-5-phosphonovalerate/pharmacology, Adenosine/*pharmacology, Animals, Evoked Potentials/drug effects, Hippocampus/drug effects/*physiology, In Vitro Techniques, Lambert N A, Membrane Potentials/drug effects, Neuroscience letters, Quinoxalines/pharmacology, Rats, Synapses/*drug effects, Synaptic Transmission/*drug effects, Teyler T J, Theophylline/analogs & derivatives/pharmacology

Advantages and disadvantages of a rapid method to train drug discrimination.

In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training…

Tags: 1988, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Tolerance, Male, Methods, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Afferent-inherent regulation of myosin heavy chain isoforms in rat muscle spindles.

Whether afferents exert their morphogenetic influence on spindles through release of trophic factors at intrafusal fiber junctions or via participation in proprioceptive pathways which modulate the motor activity to muscles was investigated by…

Aflatoxin B1 metabolism by 3-methylcholanthrene-induced hamster hepatic cytochrome P-450s.

We have studied the activation of aflatoxin B1 by hamster liver microsomes and purified hamster cytochrome P-450 isozymes using a umu mutagen test. The hamster liver microsomes or S-9 fractions were much more active than rat liver microsomes or S-9…

Age related changes of social memory/recognition in male Fischer 344 rats.

Two different habituation-dishabituation test paradigms were used to evaluate differences in social memory/recognition among 3-, 15- and 22-month-old male Fischer 344 rats. For test 1, males received three 2-min exposures to the same stimulus…

Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.

In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were…

Tags: 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Biogenic Monoamines/*metabolism, Dluzen D E, Dopamine/metabolism, Inbred F344, Male, Mechanisms of ageing and development, Olfactory Bulb/*metabolism, Rats, Serotonin/metabolism

Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.

These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu…

Aging and neuropathic pain.

Although chronic neuropathic pain disorders are more prevalent in the senescent population, little is known about how the aging process alters the thermal hyperalgesic sensitivity to peripheral nerve injury. In this study, neuropathic pain was…

Alignment of inducible vascular progenitor cells on a micro-bundle scaffold improves cardiac repair following myocardial infarction.

Ischemic heart disease is still the leading cause of death even with the advancement of pharmaceutical therapies and surgical procedures. Early vascularization in the ischemic heart is critical for a better outcome. Although stem cell therapy has…

Tags: *Cardiovascular regeneration, *Ischemic heart diseases, *Micro-bundle scaffold, *Myocardial infarction, *Neovascularization, *Stem cells, *Tissue Scaffolds, *Vascular progenitor cells, 2017, Animal, Animals, Basic research in cardiology, Cell Differentiation, Cell Proliferation, Cell Survival, Cells, Chilian William M, Coculture Techniques, Cultured, Cumpston Devan, Department of Integrative Medical Sciences, Disease Models, Dong Feng, Endothelial Progenitor Cells/metabolism/*transplantation, Enrick Molly, Fibroblast Growth Factor 2/metabolism, Hakobyan Tatev, Jamaiyar Anurag, Janota Danielle, Kolz Christopher L, Lactic Acid/*chemistry, Muscle, Myocardial Infarction/metabolism/pathology/physiopathology/*surgery, Myocardium/metabolism/*pathology, Myocytes, NEOMED College of Medicine, Newby Bi-Min Zhang, Ohanyan Vahagn, Paracrine Communication, Phenotype, Physiologic, Polyglycolic Acid/*chemistry, Polylactic Acid-Polyglycolic Acid Copolymer, Rats, Signal Transduction, Smooth, Smooth Muscle/metabolism/*transplantation, Song Hokyung, Sprague-Dawley, Stevanov Kelly, Time Factors, Tissue Engineering/*methods, Vascular Endothelial Growth Factor A/metabolism, Vascular/metabolism/*transplantation, Ventricular Remodeling, Wan Weiguo, Yin Liya

Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.

We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats.…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Dluzen D E, Dopamine Agents/*pharmacology, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Pharmaceutical Vehicles, Rats, Reserpine/pharmacology, Sprague-Dawley, Synaptic Vesicles/*drug effects/metabolism, Tetrabenazine/pharmacology, Xu K

Alteration of dopamine release by rat caudate putamen tissues superfused with alpha 2-macroglobulin.

Monoamine-activated alpha-2-macroglobulin (alpha 2M) has been shown to decrease the dopamine concentrations in rat caudate putamen (CP) in vivo as well as inhibit choline acetyltransferase activities in the culture of basal forebrain neurons. In this…

Alteration of hepatic proinflammatory cytokines is involved in the resveratrol-mediated chemoprevention of chemically-induced hepatocarcinogenesis.

Hepatocellular carcinoma (HCC), one of the most common cancers in the world, is a leading cause of cancerrelated mortality. HCC develops most frequently in the background of oxidative stress and chronic hepatic inflammation due to viral infections,…

Alterations in neurotransmitter amino acid content in the aging rat striatum are subregion dependent.

The topographical distribution of putative neurotransmitter amino acids in both

Tags: 1990, Aging/*metabolism, Amino Acids/*analysis, Animals, Corpus Striatum/*analysis, Donzanti B A, Inbred F344, Male, Neurobiology of aging, Neurotransmitter Agents/*analysis, Rats, Ung A K

An improved and rapid HPLC-EC method for the isocratic separation of amino acid neurotransmitters from brain tissue and microdialysis perfusates.

An improved, HPLC with electrochemical detection method for the isocratic separation and determination of amino acids from post-mortem brain tissue and from microdialysates of awake-behaving animals is described. Optimal conditions that maximize…

Tags: *Brain Chemistry, 1988, Amino Acids/*analysis, Animals, Chromatography, Corpus Striatum/analysis, Dialysis, Donzanti B A, Electrochemistry, High Pressure Liquid/*methods, Inbred Strains, Life sciences, Male, Neurotransmitter Agents/*analysis, Rats, Yamamoto B K

An integrated multielectrode electrophysiology system.

An integrated system for recording and analyzing electrophysiological data from multiple channels is described. The system uses an MS-DOS microcomputer, a

Tags: *Electrodes, 1991, Amplifiers, Animals, Borroni A, Chen F M, Computer Graphics, Data Display, Electronic, Electrophysiology/*instrumentation, Grover L M, Journal of neuroscience methods, LeCursi N, Microcomputers, Rats, Software, Teyler T J, Visual Cortex/physiology

Analgesic effects of serotonin and receptor-selective serotonin agonists in the rat spinal cord.

1. Serotonin (5-HT) and selective 5-HT receptor agonists were administered intrathecally (i.t.) in rats, and the antinociceptive efficacy of these agents was assessed on the tail-flick and hot plate tests. 2. The 5-HT receptor agonists examined in…

Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.

Angiotensin II (Ang II)-induced proliferation of cardiac fibroblasts is a major contributing factor to the pathogenesis of cardiac fibrosis. Ang II activates extracellular signal-regulated kinase (ERK) 1/2 to induce cardiac fibroblast proliferation,…

Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.

Whether to stage degeneration or investigate early pathology in glaucoma, examination of axonal structure and function is essential. There are a wide variety of methods available to investigators using animal models of glaucoma, with varying…

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.

Anthocyanins are known to possess potent anticarcinogenic properties against several cancers thus demonstrating potential for cancer prevention. Black currant (Ribes nigrum L., Grossulariaceae) fruits have a high anthocyanin content. This…

Anthocyanin-rich black currant (Ribes nigrum L.) extract affords chemoprevention against diethylnitrosamine-induced hepatocellular carcinogenesis in rats.

Anti-Inflammatory Mechanism Involved in Pomegranate-Mediated Prevention of Breast Cancer: the Role of NF-kappaB and Nrf2 Signaling Pathways.

Pomegranate (Punica granatum L.), a nutrient-rich unique fruit, has been used for centuries for the prevention and treatment of various inflammation-driven diseases. Based on our previous study, a characterized pomegranate emulsion (PE) exhibited a…

Tags: 10-Dimethyl-1, 2-benzanthracene/toxicity, 2017, 9, Animal Studies, Animals, Anti-Inflammatory Agents/*pharmacology, anti-inflammatory effects, Anticarcinogenic Agents/pharmacology, Apoptosis/drug effects, Bhatia Deepak, Bishayee Anupam, Breast Neoplasms, breast tumor, Cell Transformation, Chemoprevention, COX-2, Cyclooxygenase 2/genetics/metabolism, DMBA, Dose-Response Relationship, Drug, Experimental/*prevention & control, Female, Gene Expression Regulation, HSP90, HSP90 Heat-Shock Proteins/genetics/metabolism, I-kappa B Kinase/genetics/metabolism, Inflammation Mediators, Mammary Neoplasms, Mandal Animesh, Neoplasms – Prevention and Control, Neoplastic, Neoplastic/drug effects, NF-E2-Related Factor 2/genetics/*metabolism, NF-kappa B/genetics/*metabolism, NF-kappaB, Nrf2, Nutrients, Physical Education and Training, Plant Preparations/*pharmacology, Pomegranate, Punica granatum, Punicaceae/*chemistry, Rats, Signal Transduction

Antiepileptics inhibit cortical N-methyl-D-aspartate-evoked [3H]norepinephrine efflux.

The antiepileptic drugs phenytoin, valproic acid and phenobarbital were examined for their ability to inhibit N-methyl-D-aspartate (NMDA)-stimulated [3H]norepinephrine efflux from rat brain cortical slices. All three drugs inhibited efflux at varying…

Tags: 1994, Animals, Anticonvulsants/*pharmacology, Brown L M, Dose-Response Relationship, Drug, European journal of pharmacology, Female, Lee Y P, Male, N-Methylaspartate/*antagonists & inhibitors, Norepinephrine/*metabolism, Rats, Teyler T J

APeg3, a novel paternally expressed gene 3 antisense RNA transcript specifically expressed in vasopressinergic magnocellular neurons in the rat supraoptic nucleus.

Vasopressin (VP) and oxytocin (OT) play critical roles in the regulation of salt and water balance, lactation, and various behaviors and are expressed at very high levels in specific magnocellular neurons (MCNs) in the hypothalamo-neurohypophysial…

Tags: 2005, 3' Untranslated Regions/genetics, Amino Acid, Animals, Antisense/*genetics/isolation & purification/*metabolism, Brain research. Molecular brain research, Conserved Sequence/genetics, DNA-Binding Proteins/genetics/*metabolism, Gainer Harold, Gene Expression Regulation/*genetics, Genetic/genetics, Genomic Imprinting/genetics, Glasgow Eric, Hypothalamo-Hypophyseal System/cytology/metabolism, Kruppel-Like Transcription Factors, Male, Messenger/genetics/metabolism, Molecular Sequence Data, Mutsuga Noriko, Neurons/*metabolism, Nucleic Acid, Protein Kinases/genetics/*metabolism, Rats, RNA, Ryu Seung-Lim, Sequence Homology, Sprague-Dawley, Supraoptic Nucleus/cytology/*metabolism, Transcription, Transcription Factors/genetics/*metabolism, Vasopressins/*metabolism, Water-Electrolyte Balance/genetics, Yamashita Mitsuo, Zhang Bing-Jun

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