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Text
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URL Address
<a href="http://doi.org/10.4081/reumatismo.2002.272" target="_blank" rel="noreferrer noopener">http://doi.org/10.4081/reumatismo.2002.272</a>
Pages
272–284
Issue
3
Volume
54
Dublin Core
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Title
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Contributions of paleorheumatology to understanding contemporary disease.
Publisher
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Reumatismo
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-09
Subject
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Humans; Animals; Immunohistochemistry; Body Temperature; Phylogeny; Osteoarthritis/pathology; Radiography; Fossils; Bone Remodeling; DNA; DNA/genetics/isolation & purification; *Paleopathology/instrumentation/methods; *Rheumatology; Bone and Bones/chemistry/diagnostic imaging/immunology; Bone Diseases/*pathology; Collagen/immunology/isolation & purification; Dinosaurs; Gout/pathology; Joint Diseases/*pathology; Mammals; Microscopy/methods; Rheumatic Diseases/pathology; Imaging; Arthritis; Three-Dimensional; Sequence Analysis; Infectious/pathology; Reactive/pathology
Creator
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Rothschild B
Description
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As paleopathology has evolved from observational speculation to analysis of testable hypotheses, so too has recognition of its contribution to vertebrate paleontology. In the presence of significant structural and density variation (between matrix and osseous structures), x-rays provide an additional perspective of osseous response to stress and disease. As film techniques are time and cost expensive, fluoroscopy has proven a valuable alternative. Radiologic techniques also allow non-invasive "sectioning" of specimens, illustrating significant internal detail. The object can be "split" on a plane and the two portions rotated to "open" the image. This three-dimensional approach now can be applied to other forms of sequential data to their facilitate 3-dimensional representation graphically or with solid representations. Antigen and microstructure may be well preserved in fossils. Molecular preservation with retention of helical structure and sensitivity to collagenase has been demonstrated in 10,000 year old collagen. Antigen has been extracted from 100 million year old bone and documented, in situ, in 11,000 year old bone. If the appropriate site in the tissue is assessed, if antigen is still present, and if the appropriate antisera is utilized, fixation of the antibody to the specimen can be detected. Minute amounts of DNA can be amplified and analyzed. Recovery of DNA from a 40,000 year old mammoth, 17,000 year old bison and from 25 million year old insects provides opportunity for cloning and independent assessment of relationships. Implications of available technology focuses direction for development of collaborative approaches.
Identifier
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<a href="http://doi.org/10.4081/reumatismo.2002.272" target="_blank" rel="noreferrer noopener">10.4081/reumatismo.2002.272</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Paleopathology/instrumentation/methods
*Rheumatology
2002
Animals
Arthritis
Body Temperature
Bone and Bones/chemistry/diagnostic imaging/immunology
Bone Diseases/*pathology
Bone Remodeling
Collagen/immunology/isolation & purification
Dinosaurs
DNA
DNA/genetics/isolation & purification
Fossils
Gout/pathology
Humans
Imaging
Immunohistochemistry
Infectious/pathology
Joint Diseases/*pathology
Mammals
Microscopy/methods
Osteoarthritis/pathology
Phylogeny
Radiography
Reactive/pathology
Reumatismo
Rheumatic Diseases/pathology
Rothschild B
Sequence Analysis
Three-Dimensional