Browse Items · NEOMED Bibliography Database

Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro.

We have previously identified osteoactivin (OA), encoded by Gpnmb, as an osteogenic factor that stimulates osteoblast differentiation in vitro. To elucidate the importance of OA in osteogenesis, we characterized the skeletal phenotype of a mouse…

Small heterodimer partner deletion prevents hepatic steatosis and when combined with farnesoid X receptor loss protects against type 2 diabetes in mice.

Nuclear receptors farnesoid X receptor (FXR) and small heterodimer partner (SHP) are important regulators of bile acid, lipid, and glucose homeostasis. Here, we show that global Fxr (-/-) Shp(-/-) double knockout (DKO) mice are refractory to weight…

The role of NMDA receptors in long-term potentiation (LTP) and depression (LTD) in rat visual cortex.

The purpose of the present study was to improve our understanding of the role of NMDA receptors in neocortical synaptic plasticity. In slices of rat visual cortex the field potential elicited in layer III in response to white matter stimulation…

Induction of NMDA receptor-independent long-term potentiation (LTP) in visual cortex of adult rats.

The aim of this study was to examine: (1) whether long-term potentiation (LTP) can be induced in slices from adult rat visual cortex under conditions where inhibition is not antagonized, and (2) the role of N-methyl-D-aspartate (NMDA) receptors in…

Tags: 1992, Animals, Aroniadou V A, Brain research, Electric Stimulation, Evoked Potentials/physiology, In Vitro Techniques, N-Methyl-D-Aspartate/antagonists & inhibitors/drug effects/*physiology, Neuronal Plasticity/drug effects/*physiology, Rats, Receptors, Synapses/physiology, Teyler T J, Visual Cortex/*physiology

Beyond thermoregulation: metabolic function of cetacean blubber in migrating bowhead and beluga whales.

The processes of lipid deposition and utilization, via the gene leptin (Lep), are poorly understood in taxa with varying degrees of adipose storage. This study examines how these systems may have adapted in marine aquatic environments inhabited by…

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy.

BACKGROUND: Genetic variants of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) confer increased risk of developing late-onset Alzheimer's Disease (LOAD) and other neurodegenerative disorders. Recent studies provided insight into the…

A novel mechanism of neurokinin-1 receptor resensitization.

Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the…

Tags: 2002, Animals, Bennett V J, Cell Membrane/drug effects/metabolism, CHO Cells, Concanavalin A/pharmacology, Cricetinae, Monensin/pharmacology, Neurokinin-1/*agonists/*metabolism, Perrine S A, Phosphorylation/drug effects, Rats, Receptors, Simmons M A, The Journal of pharmacology and experimental therapeutics

Neurokinin-1 receptor resensitization precedes receptor recycling.

Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to…

Tags: 2005, Adenosine Triphosphate/pharmacology, Animals, Bennett V J, Binding, Calcium/metabolism, CHO Cells, Competitive, Cricetinae, Guanylyl Imidodiphosphate/pharmacology, Neurokinin-1/*metabolism, Perrine S A, Phosphorylation, Rats, Receptors, Simmons M A, Substance P/metabolism, The Journal of pharmacology and experimental therapeutics

REDUCTION OF LEARNED HELPLESSNESS BY CENTRAL ADMINISTRATION OF QUATERNARY NALTREXONE

Prior research has established that escape impairment resulting from prior inescapable shock (IS) could be reversed by the peripheral administration of the opiate antagonist naltrexone (NTX), but not the quaternary form of naltrexone (QNTX), which…

Norfenfluramine, the fenfluramine metabolite, provides stimulus control: evidence for serotonergic mediation.

Nine male rats were trained to discriminate 1.4 mg/kg norfenfluramine (NF) from its vehicle using a two-lever, food-motivated, operant discrimination task. Once trained, the rats showed a dose-dependent decrease in responding on the

Tags: 1988, Animal/*drug effects, Animals, Behavior, Boja J W, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Fenfluramine/*analogs & derivatives/*pharmacology, Inbred Strains, Male, Norfenfluramine/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Receptors, Schechter M D, Serotonin/pharmacology, Serotonin/physiology, Time Factors

Possible serotonergic and dopaminergic mediation of the

Eight male rats previously trained to discriminate 2.0 mg/kg

Icatibant for the treatment of orolingual angioedema following the administration of tissue plasminogen activator.

Tags: 2018, Airway Management, Angioedema, Angioedema – Drug Therapy, Brooks Steven, Brown Emily, Campana Christina M, Cell Surface – Antagonists and Inhibitors, Department of Emergency Medicine, Icatibant, NEOMED College of Medicine, Receptors, stroke, The American journal of emergency medicine, Tissue plasminogen activator, Tissue Plasminogen Activator – Therapeutic Use, Zimmerman Jacob

DEVELOPMENTAL ALTERATIONS IN N-METHYL-D-ASPARTATE STIMULATED H-3 NOREPINEPHRINE RELEASE IN RAT-BRAIN CORTEX AND HIPPOCAMPUS

Developmental alterations in N-methyl-D-aspartate (NMDA)-stimulated [H-3]norepinephrine release from rat brain cortical and hippocampal slices were studied. NMDA (10-1000 muM) resulted in a concentration-dependent increase in [H-3]norepinephrine…

NMDA receptor-independent LTP in basal versus apical dendrites of CA1 pyramidal cells in rat hippocampal slice.

The ability of hippocampal CA1 basal synapses to express N-methyl-D-aspartate (NMDA) receptor-independent long-term potentiation (non-NMDA LTP) was studied and compared to the simultaneously induced apical dendritic non-NMDA LTP. Non-NMDA LTP in…

Effect of epinephrine on alveolar liquid clearance in the rat.

Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations…

Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.

Hydrophobic bile acids strongly repressed transcription of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in the bile acid biosynthetic pathway in the liver. Farnesoid X receptor (FXR) repressed CYP7A1/Luc reporter activity in a transfection…

Tags: *Hydroxysteroid Dehydrogenases, *Membrane Glycoproteins, 2001, Animals, Bile Acids and Salts/*pharmacology, Caco-2 Cells, Carrier Proteins/genetics/physiology, Cell Line, Chen W, Chiang J Y, CHO Cells, Cholesterol 7-alpha-Hydroxylase/*genetics, Cricetinae, Cultured, Cytoplasmic and Nuclear/genetics/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/drug effects/genetics/physiology, DNA/metabolism, Embryo, Gene Expression/*drug effects, Genetic, Genetic/drug effects, Humans, Journal of lipid research, Kidney, Liver/metabolism, Luciferases/genetics, Mammalian, Messenger/analysis, NEOMED College of Medicine, Owsley E, Promoter Regions, Rats, Receptors, Recombinant Fusion Proteins/metabolism, Retinoic Acid/genetics/physiology, Retinoid X Receptors, Reverse Transcriptase Polymerase Chain Reaction, RNA, Stroup D, Taurocholic Acid/pharmacology, Transcription, Transcription Factors/drug effects/genetics/physiology, Transfection, Tumor Cells, Yang Y

Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis.

UNLABELLED: Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 activation also inhibits nuclear factor kappaB (NF-kappaB)-mediated inflammation. Here we…

Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).

Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyses sterol side-chain oxidation of bile acid synthesis from cholesterol, and the first reaction of the acidic bile acid biosynthetic pathway. Hydrophobic bile acids suppress human CYP27A1 gene…

Tags: *DNA-Binding Proteins, 2003, Base Sequence, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Bile Acids and Salts/*pharmacology, Binding Sites/genetics, Cell Line, Chen Wenling, Chenodeoxycholic Acid/pharmacology, Chiang John Y L, Cholestanetriol 26-Monooxygenase, Cloning, Cultured, Cytoplasmic and Nuclear/genetics/metabolism, Department of Integrative Medical Sciences, DNA, DNA/chemistry/genetics, Dose-Response Relationship, Drug, gene, Gene Expression Regulation/drug effects, Genetic/*genetics, Hepatocyte Nuclear Factor 4, Humans, Luciferases/genetics/metabolism, Molecular, Molecular Sequence Data, Mutagenesis, Mutation, NEOMED College of Medicine, Phosphoproteins/genetics/*metabolism, Promoter Regions, Receptors, Recombinant Fusion Proteins/genetics/metabolism, Response Elements/genetics, Sequence Analysis, Site-Directed, Steroid Hydroxylases/*genetics, Transcription Factors/genetics/*metabolism, Transfection, Tumor Cells

Opioids: a review.

Recent discoveries in opioid pharmacology help explain the enormous variability in clinical responses to these powerful analgesics. Although there is only one m opioid receptor gene, splice variants of that gene's expression result in a panoply of…

Tags: 2003, Analgesics, Animals, Chevlen Eric, Clinical Trials as Topic, Current pain and headache reports, Department of Internal Medicine, Drug Tolerance, Humans, mu/drug effects/genetics/physiology, NEOMED College of Medicine, Opioid, Opioid/*drug effects/genetics/physiology, Opioid/adverse effects/*therapeutic use, Pain/*drug therapy/physiopathology, Receptors, Trans-Activators/genetics

Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha(2)-macroglobulin

Human pregnancy zone protein (PZP) is a major pregnancy-associated plasma protein closely related to human alpha(2)-macroglobulin (alpha(2)M). It has been demonstrated that monoamine-activated forms of human and rat alpha(2)M and rat alpha(2)M can…

Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).

The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis. Oxysterol receptor, LXR, stimulates, whereas the bile acid receptor, FXR, inhibits CYP7A1 transcription. The…

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription.

Cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription is repressed by bile acids. The goal of this study is to elucidate the mechanism of CYP7A1 transcription by bile acid-activated farnesoid X receptor (FXR) in its native promoter and cellular…

Bile acid metabolism and signaling.

Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling molecules and metabolic regulators that activate nuclear receptors and…

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.

Tags: 2004, Animals, Bile Acids and Salts/*biosynthesis, Chiang John Y L, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback, Humans, Journal of hepatology, Lipid Metabolism, NEOMED College of Medicine, Physiological, Receptors

Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors.

Bile acids are physiological detergents that facilitate excretion, absorption, and transport of fats and sterols in the intestine and liver. Recent studies reveal that bile acids also are signaling molecules that activate several nuclear receptors…

Tags: 2003, American journal of physiology. Gastrointestinal and liver physiology, Animals, Bile Acids and Salts/biosynthesis/genetics/*physiology, Bile/*physiology, Cardiovascular Diseases/genetics/physiopathology, Chiang John Y L, Cholesterol/physiology, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Feedback/physiology, Gene Expression Regulation/physiology, Humans, Liver Diseases/genetics/physiopathology, Liver/*physiology, NEOMED College of Medicine, Receptors

Bile acids: regulation of synthesis.

Bile acids are physiological detergents that generate bile flow and facilitate intestinal absorption and transport of lipids, nutrients, and vitamins. Bile acids also are signaling molecules and inflammatory agents that rapidly activate nuclear…

Tags: 2009, Animals, Bile Acids and Salts/*metabolism, Biological, Chiang John Y L, Cholesterol 7-alpha-Hydroxylase/metabolism, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Humans, Journal of lipid research, Models, NEOMED College of Medicine, Receptors, Signal Transduction/physiology

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

Bile acids derived from cholesterol and oxysterols derived from cholesterol and bile acid synthesis pathways are signaling molecules that regulate cholesterol homeostasis in mammals. Many nuclear receptors play pivotal roles in the regulation of bile…

Tags: 2002, Animals, Bile Acids and Salts/*physiology, Chiang John Y L, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, Endocrine reviews, Gene Expression Regulation/*physiology, Humans, NEOMED College of Medicine, Receptors

Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases.

Lipids are essential components of biological membranes, fuel molecules and metabolic regulators that control cellular functions, metabolism and homeostasis. The liver plays a central role in regulating lipid metabolism and whole body lipid…

Tags: *Lipid Metabolism, 2005, Animals, Chiang John Y L, Chronic Disease, Current opinion in investigational drugs (London, England : 2000), Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Diabetes Mellitus/drug therapy/metabolism, Dyslipidemias/drug therapy/metabolism, Heart Diseases/*drug therapy/metabolism, Humans, Hypoglycemic Agents/therapeutic use, Hypolipidemic Agents/therapeutic use, Liver Diseases/*drug therapy/metabolism, Metabolic Diseases/*drug therapy/metabolism, NEOMED College of Medicine, Receptors

Intestinal Farnesoid X Receptor and Takeda G Protein Couple Receptor 5 Signaling in Metabolic Regulation.

Bile acids play a critical role in the regulation of glucose, lipid and energy metabolisms by activating the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (aka takeda G protein couple…

Tags: *Signal Transduction, 2017, Animals, Bile Acids and Salts/biosynthesis/metabolism, Boehme Shannon, Chiang John Y L, Cytoplasmic and Nuclear/*metabolism, Department of Integrative Medical Sciences, Digestive diseases (Basel, Switzerland), Donepudi Ajay, Ferrell Jessica, G-Protein-Coupled/*metabolism, Humans, Intestinal Mucosa/*metabolism, Liu Hailiang, Liver/metabolism, NEOMED College of Medicine, Pathak Preeti, Receptors

Vascular Endothelial Growth Factor and the Collateral Circulation The Story Continues

Tags: 2008, angiogenesis, Arteriogenesis, Cardiovascular System & Cardiology, Cells, Chilian W M, Circulation research, expression, Hematology, Journal Article or Conference Abstract Publication, permeability factor, Pung Y F, Receptors, skeletal-muscle, vasculogenesis, vasculotropin, vegf family-members

Impact of circadian nuclear receptor REV-ERBalpha on midbrain dopamine production and mood regulation.

The circadian nature of mood and its dysfunction in affective disorders is well recognized, but the underlying molecular mechanisms are still unclear. Here, we show that the circadian nuclear receptor REV-ERBalpha, which is associated with bipolar…

Activation of heterotrimeric G-proteins independent of a G-protein coupled receptor and the implications for signal processing.

Heterotrimeric G-proteins are key transducers for signal transfer from outside the cell, mediating signals emanating from cell-surface G-protein coupled receptors (GPCR). Many, if not all, subtypes of heterotrimeric G-proteins are also regulated by…

Tags: *Signal Transduction, 2005, Animals, Biological, Cismowski M J, G-Protein-Coupled/*metabolism, Heterotrimeric GTP-Binding Proteins/*metabolism, Humans, Lanier S M, Models, Receptors, Reviews of physiology, biochemistry and pharmacology

Non-receptor activators of heterotrimeric G-protein signaling (AGS proteins).

G-protein coupled receptor (GPCR) signaling represents one of the most conserved and ubiquitous means in mammalian cells for transferring information across the plasma membrane to the intracellular environment. Heterotrimeric G-protein subunits play…

Tags: *Signal Transduction, 2006, Animals, Biological, Cismowski Mary J, G-Protein-Coupled/*metabolism, Heterotrimeric GTP-Binding Proteins/*metabolism, Humans, Models, Receptors, Seminars in cell & developmental biology

Vagal afferents from the uterus and cervix provide direct connections to the brainstem.

Previous anatomical studies demonstrated vagal innervation to the ovary and distal colon and suggested the vagus nerve has uterine inputs. Recent behavioral and physiological evidence indicated that the vagus nerves conduct sensory information from…

Tags: 1999, Animals, Berthoud H R, Brain Stem/*anatomy & histology, Cell and tissue research, Cervix Uteri/*innervation, Collins J J, Estrogen/metabolism, Female, Immunohistochemistry, Lin C E, Neurons/cytology/metabolism, Papka R E, Rats, Receptors, Sprague-Dawley, Uterus/*innervation, Vagus Nerve/*anatomy & histology/metabolism

Sensory nerves and neuropeptides in uterine cervical ripening.

At the time of parturition (fetal delivery) the uterine cervix must "ripen," becoming soft, pliable, and dilated to accommodate the fetus' delivery. The fundamental processes underlying cervical ripening remain poorly understood. Knowledge that…

Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the…

Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells

Browse Items (215 total)