Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model
Creator
Reed-Geaghan Erin G; Croxford Andrew L; Becher Burkhard; Landreth Gary E
Publisher
Journal of Experimental Medicine
Date
2020
2020-04
Description
Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes.