1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s40123-019-00217-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s40123-019-00217-w</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 589-598 Issue 4 Volume 8 ISSN 2193-8245 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://ezproxy.neomed.idm.oclc.org/login?url=http://doi.org/10.1007/s40123-019-00217-w" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1007/s40123-019-00217-w</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Atropine 0.01% Eye Drops for Myopia Control in American Children: A Multiethnic Sample Across Three US Sites Publisher An entity responsible for making the resource available Ophthalmology And Therapy Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-12 Subject The topic of the resource Atropine; Childhood myopia; Eye drops; Myopia; Refractive error; Side effects Creator An entity primarily responsible for making the resource Larkin G Luke; Tahir Alifiya; Epley K David; Beauchamp Cynthia L; Tong John T; Clark Robert A Description An account of the resource INTRODUCTION: Topical atropine eye drops at low concentrations have been shown to slow myopia progression in East Asian studies. This study explored the effect of atropine 0.01% eye drops on controlling myopia progression in a multiethnic cohort of children in the USA. METHODS: A multicenter retrospective case-control study (n = 198) quantified the effect of adding nightly atropine 0.01% eye drops to treatment as usual on the progression of childhood (ages 6-15 years) myopia. Cases included all children treated with atropine for at least 1 year. Controls were matched to cases on both age (± 6 months) and baseline spherical equivalent refraction (SER) (± 0.50 diopters, D) at treatment initiation. The primary endpoint was the average SER myopia progression after 1, 1.5, and 2 years of therapy. A secondary outcome was the percentage of subjects with a clinically significant worsening of myopia, defined as a greater than - 0.75 D SER increase in myopia. RESULTS: The average baseline SERs for the atropine (n = 100) and control (n = 98) groups were similar (- 3.1 ± 1.9 D and - 2.8 ± 1.6 D, respectively) (p = 0.23). The average SER increase from baseline was significantly less for the atropine group than the control group at year 1 (- 0.2 ± 0.8 D compared with - 0.6 ± 0.4 D, p < 0.001) and at year 2 (- 0.3 ± 1.1 D compared with - 1.2 ± 0.7 D, p < 0.001). Secondary analysis at year 2 revealed that 80% of the control group vs. 37% of the atropine group experienced clinically significant worsening myopia of at least - 0.75 D (p < 0.001). There were no major safety issues reported in either group. CONCLUSION: Similar to results reported in Asia, atropine 0.01% eye drops significantly reduced myopia progression in a cohort of US children over 2 years of treatment. FUNDING: Nevakar, Inc. Plain language summary available for this article. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s40123-019-00217-w" target="_blank" rel="noreferrer noopener">10.1007/s40123-019-00217-w</a> PMID: 31602553 Format The file format, physical medium, or dimensions of the resource Journal Article 2019 Atropine Beauchamp Cynthia L Childhood myopia Clark Robert A Department of Emergency Medicine Epley K David Eye drops Journal Article Larkin G Luke Myopia NEOMED College of Medicine November 2019 Update Ophthalmology And Therapy Refractive error Side effects Summa Health System Akron City Hospital Tahir Alifiya Tong John T