1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bcp.2009.07.004</a>
Pages
1401–1411
Issue
11
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems.
Publisher
An entity responsible for making the resource available
Biochemical pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-12
Subject
The topic of the resource
Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Female; Male; Messenger/biosynthesis; Mice; Mutant Strains; Protein Binding; Reserpine/pharmacology; RNA; Sex Characteristics; Substantia Nigra/*metabolism; Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
Creator
An entity primarily responsible for making the resource
Ji Jing; Bourque Melanie; Di Paolo Therese; Dluzen Dean E
Description
An account of the resource
Female mice with a heterozygous mutation of their dopamine transporter (+/- DAT) showed relatively robust reductions in striatal DAT specific binding (38-50%), while +/- DAT males showed modest reductions (24-32%). Significant decreases in substantia nigra DAT specific binding (42%) and mRNA (24%) were obtained in +/- DAT females, but not +/- DAT males (19% and 5%, respectively). The effects of this DAT perturbation upon vesicular monoamine transporter-2 (VMAT-2) function revealed significantly greater reserpine-evoked DA output from +/+ and +/- DAT female as compared to male mice and the DA output profile differed markedly between +/+ and +/- DAT females, but not males. No changes in VMAT-2 protein or mRNA levels were present among these conditions. On the basis of these data, we propose: (1) a genetic mutation of the DAT does not exert equivalent effects upon the DAT in female and male mice, with females being more affected; (2) an alteration in the DAT may also affect VMAT-2 function; (3) this interaction between DAT and VMAT-2 function is more prevalent in female mice; and (4) the +/- DAT mutation affects VMAT-2 function through an indirect mechanism, that does not involve an alteration in VMAT-2 protein or mRNA. Such DAT/VMAT-2 interactions can be of significance to the gender differences observed in drug addiction and Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bcp.2009.07.004" target="_blank" rel="noreferrer noopener">10.1016/j.bcp.2009.07.004</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Biochemical pharmacology
Bourque Melanie
Corpus Striatum/*metabolism
Di Paolo Therese
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Female
Ji Jing
Male
Messenger/biosynthesis
Mice
Mutant Strains
Protein Binding
Reserpine/pharmacology
RNA
Sex Characteristics
Substantia Nigra/*metabolism
Vesicular Monoamine Transport Proteins/antagonists & inhibitors/biosynthesis/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20309</a>
Pages
347–353
Issue
5
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Testosterone modulation of striatal dopamine output in orchidectomized mice.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
Adrenergic Uptake Inhibitors/pharmacology; Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism/pharmacology; Male; Mice; Neural Pathways/drug effects/*metabolism; Orchiectomy; Potassium Chloride/pharmacology; Presynaptic Terminals/drug effects/metabolism; Reserpine/pharmacology; Sex Characteristics; Substantia Nigra/drug effects/*metabolism; Synaptic Transmission/drug effects/physiology; Synaptic Vesicles/drug effects/metabolism; Testosterone/*metabolism; Vesicular Monoamine Transport Proteins/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Shemisa Kamal; Kunnathur Vidhya; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
An account of the resource
Three experiments are presented in which dopamine (DA) responses from superfused striatal tissue of orchidectomized (ORCH) mice treated or not with testosterone (T) are compared. In experiment 1, potassium-stimulated DA output was significantly greater in ORCH vs. ORCH+T mice. This profile was reversed when reserpine was infused in experiment 2, with DA output being significantly greater in ORCH+T vs. ORCH mice. In experiment 3, the amount of DA recovered following infusion of DA indicated no statistically significant differences in DA recoveries between ORCH and ORCH+T mice as tested in this paradigm. The findings that both potassium- and reserpine-induced DA responses are altered significantly by T suggests that one potential site of T action might involve the storage/uptake of DA within the vesicles of these neurons. Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">10.1002/syn.20309</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Adrenergic Uptake Inhibitors/pharmacology
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism/pharmacology
Kunnathur Vidhya
Liu Bin
Male
Mice
Neural Pathways/drug effects/*metabolism
Orchiectomy
Potassium Chloride/pharmacology
Presynaptic Terminals/drug effects/metabolism
Reserpine/pharmacology
Salvaterra Ty J
Sex Characteristics
Shemisa Kamal
Substantia Nigra/drug effects/*metabolism
Synapse (New York, N.Y.)
Synaptic Transmission/drug effects/physiology
Synaptic Vesicles/drug effects/metabolism
Testosterone/*metabolism
Vesicular Monoamine Transport Proteins/drug effects/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s007020050114</a>
Pages
1091–1101
Issue
10
Volume
105
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1905-06
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Dopamine Agents/*pharmacology; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Pharmaceutical Vehicles; Rats; Reserpine/pharmacology; Sprague-Dawley; Synaptic Vesicles/*drug effects/metabolism; Tetrabenazine/pharmacology
Creator
An entity primarily responsible for making the resource
Xu K; Dluzen D E
Description
An account of the resource
We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats. Specifically, we tested the effects of two 20-min infusions of L-DOPA (5 uM) upon DA and DOPAC output (pg/mg/min) in reserpine (5 mg/kg, i.p., 24 hours before sacrifice; n=11), TBZ (30 mg/kg, i.p. 1 hour before sacrifice; n=8) or vehicle (n=21) treated rats. There was an overall significantly higher L-DOPA evoked DA output from the vehicle (12.22+/-1.74) versus reserpine (4.39+/-2.40) (p \textless 0.05), but not TBZ (9.16+/-2.81) treated rats. In addition, the DA response to the second L-DOPA infusion was significantly increased over that of the first response in the vehicle (9.40+/-2.11 vs. 15.04+/-2.78) (p \textless 0.05), but not reserpine or TBZ treated rats. The overall DOPAC outputs did not achieve a statistically significant difference among all treatment groups. However, the DOPAC outputs following the second L-DOPA infusion were significantly reduced in reserpine (41.15+/-6.10 vs. 20.27+/-4.54) and TBZ (21.38+/-4.41 vs. 10.87+/-2.36) (both p \textless 0.05), but not vehicle (28.99+/-4.00 vs. 24.91+/-4.78) treated rats. We conclude that: 1) the storage capacity of DA neurons is one of the important elements involved in affecting L-DOPA's effects upon DA and DOPAC output, 2) the shunting of storage to metabolism may represent a common characteristic in impaired nigrostriatal dopaminergic system, and 3) TBZ may operate differently from reserpine in the nigrostriatal dopaminergic system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s007020050114" target="_blank" rel="noreferrer noopener">10.1007/s007020050114</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
3
4-Dihydroxyphenylacetic Acid/*metabolism
Animals
Dluzen D E
Dopamine Agents/*pharmacology
Dopamine/*metabolism
Journal of neural transmission (Vienna, Austria : 1996)
Levodopa/*pharmacology
Male
Pharmaceutical Vehicles
Rats
Reserpine/pharmacology
Sprague-Dawley
Synaptic Vesicles/*drug effects/metabolism
Tetrabenazine/pharmacology
Xu K