1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
2095–2102
Issue
10
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Unified theory of the origins of erosive arthritis: conditioning as a protective/directing mechanism?
Publisher
An entity responsible for making the resource available
The Journal of rheumatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-10
Subject
The topic of the resource
Humans; United States/epidemiology; *Paleontology; Catchment Area (Health); Arthritis; Tuberculosis; Spondylitis; Ankylosing/complications/epidemiology; Osteoarticular/complications/epidemiology; Rheumatoid/epidemiology/*etiology
Creator
An entity primarily responsible for making the resource
Rothschild Bruce M; Rothschild Christine; Helbling Mark
Description
An account of the resource
OBJECTIVE: To validate the western Tennessee River limits of the originally described rheumatoid arthritis (RA) catchment area and to assess the possibility that absence of tuberculosis allowed the original development of RA. The hypothesis that RA was related to tuberculosis was once a driving force in treatment approach. RA initially was very limited in geographic distribution, in contrast to tuberculosis. Classical tubercular lesions were not observed in the rheumatoid catchment area in ancient times. Similarities between clinical and radiologic manifestations of spondyloarthropathy (SpA) and adjuvant arthritis raised the possibility of a potential conditioning role for occurrence of nonrheumatoid erosive arthritis. METHODS: Skeletal samples from ancient RA catchment and non-catchment areas were compared for frequency of tubercular-relatable pathologies. RESULTS: Tubercular-relatable osseous pathologies were found only outside the rheumatoid catchment area (p \textless 0.0001). The original RA catchment area was confirmed not to extend beyond the western portion of the Tennessee River. CONCLUSION: There is an inverse relationship between occurrence of tuberculosis and RA in the Archaic and Early Woodland periods of North America. The virtually universal presence of tuberculosis in contiguous Amerindian populations contrasts dramatically with its absence in the ancient catchment area for RA. Conversely, SpA and tuberculosis do occur in the same populations. Tuberculosis may represent a conditioning agent for development of SpA, but at least potentially provides protection against development of RA.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Paleontology
2003
Ankylosing/complications/epidemiology
Arthritis
Catchment Area (Health)
Helbling Mark
Humans
Osteoarticular/complications/epidemiology
Rheumatoid/epidemiology/*etiology
Rothschild Bruce M
Rothschild Christine
Spondylitis
The Journal of rheumatology
Tuberculosis
United States/epidemiology