1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.4161/chan.24328" target="_blank" rel="noreferrer noopener">http://doi.org/10.4161/chan.24328</a> Pages 211–214 Issue 3 Volume 7 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource A TRP to cardiac fibroblast differentiation. Publisher An entity responsible for making the resource available Channels (Austin, Tex.) Date A point or period of time associated with an event in the lifecycle of the resource 2013 2013-06 Subject The topic of the resource Female; Humans; Male; Animals; TRPV4; *Wound Healing; TRPV Cation Channels/*metabolism; integrin; *Cell Differentiation; cardiac fibroblast; myofibroblast; *Calcium Signaling; *Cell Transdifferentiation; Atrial Fibrillation/*metabolism; differentiation; ECM stiffness; Fibroblasts/*metabolism/*physiology; mechanical signaling; Myofibroblasts/*cytology/*metabolism; Rho/ROCK; TRPC Cation Channels/*metabolism; TRPM Cation Channels/*metabolism; Cellular; *Mechanotransduction Creator An entity primarily responsible for making the resource Thodeti Charles K; Paruchuri Sailaja; Meszaros J Gary Description An account of the resource The differentiation of cardiac fibroblasts to myofibroblasts is one of the key events during cardiac remodeling, however, the molecular mechanism underlying this process is not well known. Calcium signaling plays an important role in the regulation of cardiac fibroblast function, but its role in the differentiation of fibroblasts is undefined. Recently four Transient Receptor Potential (TRP) channels TRPM7, TRPC3, TRPC6 and TRPV4 were shown to be crucial for the differentiation of cardiac fibroblasts to myofibroblasts. This addendum sums up the roles described for these four TRP channels in cardiac fibroblast differentiation, and discusses the possible molecular mechanisms underlying this process and its relevance for cardiac remodeling in disease. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.4161/chan.24328" target="_blank" rel="noreferrer noopener">10.4161/chan.24328</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Calcium Signaling *Cell Differentiation *Cell Transdifferentiation *Mechanotransduction *Wound Healing 2013 Animals Atrial Fibrillation/*metabolism cardiac fibroblast Cellular Channels (Austin, Tex.) Department of Integrative Medical Sciences differentiation ECM stiffness Female Fibroblasts/*metabolism/*physiology Humans integrin Male mechanical signaling Meszaros J Gary myofibroblast Myofibroblasts/*cytology/*metabolism NEOMED College of Medicine Paruchuri Sailaja Rho/ROCK Thodeti Charles K TRPC Cation Channels/*metabolism TRPM Cation Channels/*metabolism TRPV Cation Channels/*metabolism TRPV4