1
40
8
-
Text
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URL Address
<a href="http://doi.org/10.3389/fnsys.2014.00162" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnsys.2014.00162</a>
Pages
162–162
Volume
8
Dublin Core
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Title
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Developmental hearing loss impairs signal detection in noise: putative central mechanisms.
Publisher
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Frontiers in systems neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
masking; auditory cortex; conductive hearing loss; electrophysiology; gerbil; intracellular; noise; signal detection
Creator
An entity primarily responsible for making the resource
Gay Jennifer D; Voytenko Sergiy V; Galazyuk Alexander V; Rosen Merri J
Description
An account of the resource
Listeners with hearing loss have difficulty processing sounds in noisy environments. This is most noticeable for speech perception, but is reflected in a basic auditory processing task: detecting a tonal signal in a noise background, i.e., simultaneous masking. It is unresolved whether the mechanisms underlying simultaneous masking arise from the auditory periphery or from the central auditory system. Poor detection in listeners with sensorineural hearing loss (SNHL) is attributed to cochlear hair cell damage. However, hearing loss alters neural processing in the central auditory system. Additionally, both psychophysical and neurophysiological data from normally hearing and impaired listeners suggest that there are additional contributions to simultaneous masking that arise centrally. With SNHL, it is difficult to separate peripheral from central contributions to signal detection deficits. We have thus excluded peripheral contributions by using an animal model of early conductive hearing loss (CHL) that provides auditory deprivation but does not induce cochlear damage. When tested as adults, animals raised with CHL had increased thresholds for detecting tones in simultaneous noise. Furthermore, intracellular in vivo recordings in control animals revealed a cortical correlate of simultaneous masking: local cortical processing reduced tone-evoked responses in the presence of noise. This raises the possibility that altered cortical responses which occur with early CHL can influence even simple signal detection in noise.
Identifier
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<a href="http://doi.org/10.3389/fnsys.2014.00162" target="_blank" rel="noreferrer noopener">10.3389/fnsys.2014.00162</a>
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2014
auditory cortex
conductive hearing loss
Department of Anatomy & Neurobiology
Electrophysiology
Frontiers in systems neuroscience
Galazyuk Alexander V
Gay Jennifer D
gerbil
intracellular
masking
NEOMED College of Medicine
Noise
Rosen Merri J
signal detection
Voytenko Sergiy V
-
Text
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URL Address
<a href="http://doi.org/10.3389/fnins.2016.00263" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fnins.2016.00263</a>
Pages
263–263
Volume
10
Dublin Core
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Title
A name given to the resource
Benefits of Stimulus Exposure: Developmental Learning Independent of Task Performance.
Publisher
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Frontiers in neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
1905-07
Subject
The topic of the resource
development; adolescent; adult; auditory perception; experience; gap detection; learning; prepulse inhibition
Creator
An entity primarily responsible for making the resource
Green David B; Ohlemacher Jocelyn; Rosen Merri J
Description
An account of the resource
Perceptual learning (training-induced performance improvement) can be elicited by task-irrelevant stimulus exposure in humans. In contrast, task-irrelevant stimulus exposure in animals typically disrupts perception in juveniles while causing little to no effect in adults. This may be due to the extent of exposure, which is brief in humans while chronic in animals. Here we assessed the effects of short bouts of passive stimulus exposure on learning during development in gerbils, compared with non-passive stimulus exposure (i.e., during testing). We used prepulse inhibition of the acoustic startle response, a method that can be applied at any age, to measure gap detection thresholds across four age groups, spanning development. First, we showed that both gap detection thresholds and gap detection learning across sessions displayed a long developmental trajectory, improving throughout the juvenile period. Additionally, we demonstrated larger within- and across-animal performance variability in younger animals. These results are generally consistent with results in humans, where there are extended developmental trajectories for both the perception of temporally-varying signals, and the effects of perceptual training, as well as increased variability and poorer performance consistency in children. We then chose an age (mid-juveniles) that displayed clear learning over sessions in order to assess effects of brief passive stimulus exposure on this learning. We compared learning in mid-juveniles exposed to either gap detection testing (gaps paired with startles) or equivalent gap exposure without testing (gaps alone) for three sessions. Learning was equivalent in both these groups and better than both naive age-matched animals and controls receiving no gap exposure but only startle testing. Thus, short bouts of exposure to gaps independent of task performance is sufficient to induce learning at this age, and is as effective as gap detection testing.
Identifier
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<a href="http://doi.org/10.3389/fnins.2016.00263" target="_blank" rel="noreferrer noopener">10.3389/fnins.2016.00263</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2016
Adolescent
Adult
Auditory Perception
Department of Anatomy & Neurobiology
development
experience
Frontiers in neuroscience
gap detection
Green David B
Learning
NEOMED College of Medicine
Ohlemacher Jocelyn
prepulse inhibition
Rosen Merri J
-
Text
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URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.3340-10.2010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.3340-10.2010</a>
Pages
15509–15520
Issue
46
Volume
30
Dublin Core
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Title
A name given to the resource
Exploiting development to evaluate auditory encoding of amplitude modulation.
Publisher
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-11
Subject
The topic of the resource
Female; Male; Animals; Acoustic Stimulation/methods; Age Factors; Auditory Perception/*physiology; Gerbillinae; Auditory Threshold/*physiology; Auditory Cortex/*growth & development; Auditory Pathways/*growth & development
Creator
An entity primarily responsible for making the resource
Rosen Merri J; Semple Malcolm N; Sanes Dan H
Description
An account of the resource
During development, detection for many percepts matures gradually. This provides a natural system in which to investigate the neural mechanisms underlying performance differences: those aspects of neural activity that mature in conjunction with behavioral performance are more likely to subserve detection. In principle, the limitations on performance could be attributable to either immature sensory encoding mechanisms or an immature decoding of an already-mature sensory representation. To evaluate these alternatives in awake gerbil auditory cortex, we measured neural detection of sinusoidally amplitude-modulated (sAM) stimuli, for which behavioral detection thresholds display a prolonged maturation. A comparison of single-unit responses in juveniles and adults revealed that encoding of static tones was adult like in juveniles, but responses to sAM depth were immature. Since perceptual performance may reflect the activity of an animal's most sensitive neurons, we analyzed the d prime curves of single neurons and found an equivalent percentage with highly sensitive thresholds in juvenile and adult animals. In contrast, perceptual performance may reflect the pooling of information from neurons with a range of sensitivities. We evaluated a pooling model that assumes convergence of a population of inputs at a downstream target neuron and found poorer sAM detection thresholds for juveniles. Thus, if sAM detection is based on the most sensitive neurons, then immature behavioral performance is best explained by an immature decoding mechanism. However, if sAM detection is based on a population response, then immature detection thresholds are more likely caused by an inadequate sensory representation.
Identifier
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<a href="http://doi.org/10.1523/JNEUROSCI.3340-10.2010" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.3340-10.2010</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Acoustic Stimulation/methods
Age Factors
Animals
Auditory Cortex/*growth & development
Auditory Pathways/*growth & development
Auditory Perception/*physiology
Auditory Threshold/*physiology
Female
Gerbillinae
Male
Rosen Merri J
Sanes Dan H
Semple Malcolm N
The Journal of neuroscience : the official journal of the Society for Neuroscience
-
Text
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URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.0916-17.2017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.0916-17.2017</a>
Pages
7759–7771
Issue
32
Volume
37
Dublin Core
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Title
A name given to the resource
Brief Stimulus Exposure Fully Remediates Temporal Processing Deficits Induced by Early Hearing Loss.
Publisher
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The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-08
Subject
The topic of the resource
Female; Male; Animals; Age Factors; *auditory cortex; *development; *gap detection; *hearing loss; *remediation; *temporal coding; Acoustic Stimulation/*methods; Auditory Cortex/*physiology/*physiopathology; Auditory Perception/*physiology; Gerbillinae; Hearing Loss/*physiopathology; Brain Stem/*physiology; Evoked Potentials; Auditory
Creator
An entity primarily responsible for making the resource
Green David B; Mattingly Michelle M; Ye Yi; Gay Jennifer D; Rosen Merri J
Description
An account of the resource
In childhood, partial hearing loss can produce prolonged deficits in speech perception and temporal processing. However, early therapeutic interventions targeting temporal processing may improve later speech-related outcomes. Gap detection is a measure of auditory temporal resolution that relies on the auditory cortex (ACx), and early auditory deprivation alters intrinsic and synaptic properties in the ACx. Thus, early deprivation should induce deficits in gap detection, which should be reflected in ACx gap sensitivity. We tested whether earplugging-induced, early transient auditory deprivation in male and female Mongolian gerbils caused correlated deficits in behavioral and cortical gap detection, and whether these could be rescued by a novel therapeutic approach: brief exposure to gaps in background noise. Two weeks after earplug removal, animals that had been earplugged from hearing onset throughout auditory critical periods displayed impaired behavioral gap detection thresholds (GDTs), but this deficit was fully reversed by three 1 h sessions of exposure to gaps in noise. In parallel, after earplugging, cortical GDTs increased because fewer cells were sensitive to short gaps, and gap exposure normalized this pattern. Furthermore, in deprived animals, both first-spike latency and first-spike latency jitter increased, while spontaneous and evoked firing rates decreased, suggesting that deprivation causes a wider range of perceptual problems than measured here. These cortical changes all returned to control levels after gap exposure. Thus, brief stimulus exposure, perhaps in a salient context such as the unfamiliar placement into a testing apparatus, rescued impaired gap detection and may have potential as a remediation tool for general auditory processing deficits.SIGNIFICANCE STATEMENT Hearing loss in early childhood leads to impairments in auditory perception and language processing that can last well beyond the restoration of hearing sensitivity. Perceptual deficits can be improved by training, or by acoustic enrichment in animal models, but both approaches involve extended time and effort. Here, we used a novel remediation technique, brief periods of auditory stimulus exposure, to fully remediate cortical and perceptual deficits in gap detection induced by early transient hearing loss. This technique also improved multiple cortical response properties. Rescue by this efficient exposure regime may have potential as a therapeutic tool to remediate general auditory processing deficits in children with perceptual challenges arising from early hearing loss.
Identifier
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<a href="http://doi.org/10.1523/JNEUROSCI.0916-17.2017" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.0916-17.2017</a>
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*auditory cortex
*Development
*gap detection
*Hearing loss
*remediation
*temporal coding
2017
Acoustic Stimulation/*methods
Age Factors
Animals
Auditory
Auditory Cortex/*physiology/*physiopathology
Auditory Perception/*physiology
Brain Stem/*physiology
Department of Anatomy & Neurobiology
Evoked Potentials
Female
Gay Jennifer D
Gerbillinae
Green David B
Hearing Loss/*physiopathology
Male
Mattingly Michelle M
NEOMED College of Medicine
Rosen Merri J
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ye Yi
-
Text
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URL Address
<a href="http://doi.org/10.1371/journal.pone.0041514" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0041514</a>
Pages
e41514–e41514
Issue
7
Volume
7
Dublin Core
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Title
A name given to the resource
Diminished behavioral and neural sensitivity to sound modulation is associated with moderate developmental hearing loss.
Publisher
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PloS one
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
1905-7
Subject
The topic of the resource
Female; Male; Animals; Gerbillinae; *Attention; *Behavior; Neurons; Animal; Hearing Loss; Afferent/pathology; Conductive/pathology/*physiopathology
Creator
An entity primarily responsible for making the resource
Rosen Merri J; Sarro Emma C; Kelly Jack B; Sanes Dan H
Description
An account of the resource
The acoustic rearing environment can alter central auditory coding properties, yet altered neural coding is seldom linked with specific deficits to adult perceptual skills. To test whether developmental hearing loss resulted in comparable changes to perception and sensory coding, we examined behavioral and neural detection thresholds for sinusoidally amplitude modulated (sAM) stimuli. Behavioral sAM detection thresholds for slow (5 Hz) modulations were significantly worse for animals reared with bilateral conductive hearing loss (CHL), as compared to controls. This difference could not be attributed to hearing thresholds, proficiency at the task, or proxies for attention. Detection thresholds across the groups did not differ for fast (100 Hz) modulations, a result paralleling that seen in humans. Neural responses to sAM stimuli were recorded in single auditory cortex neurons from separate groups of awake animals. Neurometric analyses indicated equivalent thresholds for the most sensitive neurons, but a significantly poorer detection threshold for slow modulations across the population of CHL neurons as compared to controls. The magnitude of the neural deficit matched that of the behavioral differences, suggesting that a reduction of sensory information can account for limitations to perceptual skills.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0041514" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0041514</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attention
*Behavior
2012
Afferent/pathology
Animal
Animals
Conductive/pathology/*physiopathology
Department of Anatomy & Neurobiology
Female
Gerbillinae
Hearing Loss
Kelly Jack B
Male
NEOMED College of Medicine
Neurons
PloS one
Rosen Merri J
Sanes Dan H
Sarro Emma C
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00114.2018</a>
Pages
1558–1571
Issue
4
Volume
120
Dublin Core
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Title
A name given to the resource
Late maturation of backward masking in auditory cortex.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
auditory; cortex; detection; development; masking
Creator
An entity primarily responsible for making the resource
Mattingly Michelle M; Donell Brittany M; Rosen Merri J
Description
An account of the resource
Speech perception relies on the accurate resolution of brief, successive sounds that change rapidly over time. Deficits in the perception of such sounds, indicated by a reduced ability to detect signals during auditory backward masking, strongly relate to language processing difficulties in children. Backward masking during normal development has a longer maturational trajectory than many other auditory percepts, implicating the involvement of central auditory neural mechanisms with protracted developmental time courses. Despite the importance of this percept, its neural correlates are not well described at any developmental stage. We therefore measured auditory cortical responses to masked signals in juvenile and adult Mongolian gerbils and quantified the detection ability of individual neurons and neural populations in a manner comparable with psychoacoustic measurements. Perceptually, auditory backward masking manifests as higher thresholds for detection of a short signal followed by a masker than for the same signal in silence. Cortical masking was driven by a combination of suppressed responses to the signal and a reduced dynamic range available for signal detection in the presence of the masker. Both coding elements contributed to greater masked threshold shifts in juveniles compared with adults, but signal-evoked firing suppression was more pronounced in juveniles. Neural threshold shifts were a better match to human psychophysical threshold shifts when quantified with a longer temporal window that included the response to the delayed masker, suggesting that temporally selective listening may contribute to age-related differences in backward masking. NEW & NOTEWORTHY In children, auditory detection of backward masked signals is immature well into adolescence, and detection deficits correlate with problems in speech processing. Our auditory cortical recordings reveal immature backward masking in adolescent animals that mirrors the prolonged development seen in children. This is driven by both signal-evoked suppression and dynamic range reduction. An extended window of analysis suggests that differences in temporally focused listening may contribute to late maturing thresholds for backward masked signals.
Identifier
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<a href="http://doi.org/10.1152/jn.00114.2018" target="_blank" rel="noreferrer noopener">10.1152/jn.00114.2018</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Auditory
cortex
Department of Anatomy & Neurobiology
detection
development
Donell Brittany M
Journal of neurophysiology
masking
Mattingly Michelle M
NEOMED College of Medicine
Rosen Merri J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1121/1.5049369" target="_blank" rel="noreferrer noopener">http://doi.org/10.1121/1.5049369</a>
Pages
667–667
Issue
2
Volume
144
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Development of perception and perceptual learning for multi-timescale filtered speech.
Publisher
An entity responsible for making the resource available
The Journal of the Acoustical Society of America
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-08
Creator
An entity primarily responsible for making the resource
Huyck Julia Jones; Rosen Merri J
Description
An account of the resource
The perception of temporally changing auditory signals has a gradual developmental trajectory. Speech is a time-varying signal, and slow changes in speech (filtered at 0-4 Hz) are preferentially processed by the right hemisphere, while the left extracts faster changes (filtered at 22-40 Hz). This work examined the ability of 8- to 19-year-olds to both perceive and learn to perceive filtered speech presented diotically for each filter type (low vs high) and dichotically for preferred or non-preferred laterality. Across conditions, performance improved with increasing age, indicating that the ability to perceive filtered speech continues to develop into adolescence. Across age, performance was best when both bands were presented dichotically, but with no benefit for presentation to the preferred hemisphere. Listeners thus integrated slow and fast transitions between the two ears, benefitting from more signal information, but not in a hemisphere-specific manner. After accounting for potential ceiling effects, learning was greatest when both bands were presented dichotically. These results do not support the idea that cochlear implants could be improved by providing differentially filtered information to each ear. Listeners who started with poorer performance learned more, a factor which could contribute to the positive cochlear implant outcomes typically seen in younger children.
Identifier
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<a href="http://doi.org/10.1121/1.5049369" target="_blank" rel="noreferrer noopener">10.1121/1.5049369</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Department of Anatomy & Neurobiology
Huyck Julia Jones
NEOMED College of Medicine
Rosen Merri J
The Journal of the Acoustical Society of America
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2015.07.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2015.07.001</a>
Pages
206–217
Volume
253
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
An improved approach to separating startle data from noise.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
*Electronic Data Processing; *Noise; Acoustic startle reflex; Acoustic Stimulation/methods; Analysis of Variance; Animal locomotion; Animals; Auditory/*physiology; Automated classification; Evoked Potentials; Inbred CBA; Male; Mice; Reflex; Startle waveform analysis; Startle/*physiology; Time Factors; Video Recording
Creator
An entity primarily responsible for making the resource
Grimsley Calum A; Longenecker Ryan J; Rosen Merri J; Young Jesse W; Grimsley Jasmine M S; Galazyuk Alexander V
Description
An account of the resource
BACKGROUND: The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. The ASR can be modulated by external stimuli and internal state, making it a useful tool in many disciplines. ASR data collection and interpretation varies greatly across laboratories making comparisons a challenge. NEW METHOD: Here we investigate the animal movement associated with a startle in mouse (CBA/CaJ). Movements were simultaneously captured with high-speed video and a piezoelectric startle plate. We also use simple mathematical extrapolations to convert startle data (force) into center of mass displacement ("height"), which incorporates the animal's mass. RESULTS: Startle plate force data revealed a stereotype waveform associated with a startle that contained three distinct peaks. This waveform allowed researchers to separate trials into 'startles' and 'no-startles' (termed 'manual classification). Fleiss' kappa and Krippendorff"s alpha (0.865 for both) indicate very good levels of agreement between researchers. Further work uses this waveform to develop an automated startle classifier. The automated classifier compares favorably with manual classification. A two-way ANOVA reveals no significant difference in the magnitude of the 3 peaks as classified by the manual and automated methods (P1: p=0.526, N1: p=0.488, P2: p=0.529). COMPARISON WITH EXISTING METHOD(S): The ability of the automated classifier was compared with three other commonly used classification methods; the automated classifier far outperformed these methods. CONCLUSIONS: The improvements made allow researchers to automatically separate startle data from noise, and normalize for an individual animal's mass. These steps ease inter-animal and inter-laboratory comparisons of startle data.
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2015.07.001" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2015.07.001</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Electronic Data Processing
*Noise
2015
Acoustic startle reflex
Acoustic Stimulation/methods
Analysis of Variance
Animal locomotion
Animals
Auditory/*physiology
Automated classification
Department of Anatomy & Neurobiology
Evoked Potentials
Galazyuk Alexander V
Grimsley Calum A
Grimsley Jasmine M S
Inbred CBA
Journal of neuroscience methods
Longenecker Ryan J
Male
Mice
NEOMED College of Medicine
Reflex
Rosen Merri J
Startle waveform analysis
Startle/*physiology
Time Factors
Video Recording
Young Jesse W