1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.etap.2017.11.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.etap.2017.11.005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
46-52
Volume
57
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chronic exposure to a glyphosate-containing pesticide leads to mitochondrial dysfunction and increased reactive oxygen species production in Caenorhabditis elegans
Publisher
An entity responsible for making the resource available
Environmental Toxicology and Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
C. elegans; Glyphosate; Hydrogen peroxide; Mitochondrial inhibition; oxidative stress; Toxicology; Environmental Sciences & Ecology; Pharmacology & Pharmacy; parkinsons-disease; brain; alzheimers-disease; mechanisms; degeneration; species; neurodegenerative diseases; 6-ohda; C. elegans; complex-i; Herbicide; Reactive oxygen
Creator
An entity primarily responsible for making the resource
Bailey D C; Todt C E; Burchfield S L; Pressley A S; Denney R D; Snapp I B; Negga R; Traynor W L; Fitsanakis V A
Description
An account of the resource
Glyphosate-containing herbicides are among the most widely-used in the world. Although glyphosate itself is relatively non-toxic, growing evidence suggests that commercial herbicide formulations may lead to increased oxidative stress and mitochondrial inhibition. In order to assess these mechanisms in vivo, we chronically (24 h) exposed Caenorhabditis elegans to various concentrations of the glyphosate-containing herbicide TouchDown (TD). Following TD exposure, we evaluated the function of specific mitochondrial electron transport chain complexes. Initial oxygen consumption studies demonstrated inhibition in mid- and high-TD concentration treatment groups compared to controls. Results from tetramethylrhodamine ethyl ester and ATP assays indicated reductions in the proton gradient and ATP levels, respectively. Additional studies were designed to determine whether TD exposure resulted in increased reactive oxygen species (ROS) production. Data from hydrogen peroxide, but not superoxide or hydroxyl radical, assays showed statistically significant increases in this specific ROS. Taken together, these data indicate that exposure of Caenorhabditis elegans to TD leads to mitochondrial inhibition and hydrogen peroxide production.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.etap.2017.11.005" target="_blank" rel="noreferrer noopener">10.1016/j.etap.2017.11.005</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2018
6-ohda
alzheimers-disease
Bailey D C
Brain
Burchfield S L
C. elegans
complex-i
degeneration
Denney R D
Department of Pharmaceutical Sciences
Environmental Sciences & Ecology
Environmental toxicology and pharmacology
Fitsanakis V A
Glyphosate
Herbicide
Hydrogen peroxide
Journal Article or Conference Abstract Publication
mechanisms
Mitochondrial inhibition
Negga R
NEOMED College of Pharmacy
Neurodegenerative Diseases
Oxidative Stress
parkinsons-disease
Pharmacology & Pharmacy
Pressley A S
Reactive oxygen
Snapp I B
SPECIES
Todt C E
Toxicology
Traynor W L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1093/biolinnean/blz051" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/biolinnean/blz051</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
762-770
Issue
4
Volume
127
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Differences in kinematic plasticity between freshwater turtle species underlie differences in swimming performance in response to varying flow conditions.
Publisher
An entity responsible for making the resource available
Biological Journal of the Linnean Society
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-08
Subject
The topic of the resource
ANIMAL swimming; behavioural plasticity; Biomechanics; HYDRAULICS; locomotion; LOGGERHEAD turtle; plasticity; reptile; SPECIES; TETRAPODS; TURTLES
Creator
An entity primarily responsible for making the resource
Mayerl Christopher J; Hicks Kirsten E; Blob Richard W
Description
An account of the resource
The distribution and performance of aquatic vertebrates can be linked strongly to their ability to perform in variable conditions of flowing water. Performance in these variable conditions can be affected by both morphology and behaviour, and animals that experience more variable environments often show greater behavioural plasticity that improves performance in those environments. One common metric of performance is swimming stability, which can constitute a majority of the daily energy budget of swimming animals. We compared the body oscillations arising from recoil forces of the limbs of two species of freshwater turtles as they swam in different flow conditions: the lentic specialist Emydura subglobosa and the habitat generalist Chrysemys picta. We found that E. subglobosa experienced more limited oscillations in still water than C. picta , but that C. picta had a greater kinematic response to increased flow speed that might contribute to their improved performance in flowing water. These results provide insight into how secondarily aquatic tetrapods respond to the functional demands of variation in flow, helping to build understanding of the relationship between energetics, kinematics and performance of such lineages in different environments. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1093/biolinnean/blz051" target="_blank" rel="noreferrer noopener">10.1093/biolinnean/blz051</a>
2019
ANIMAL swimming
behavioural plasticity
Biological Journal of the Linnean Society
biomechanics
Blob Richard W
Department of Anatomy & Neurobiology
Hicks Kirsten E
HYDRAULICS
Locomotion
LOGGERHEAD turtle
Mayerl Christopher J
NEOMED College of Medicine
plasticity
reptile
September 2019 Update
SPECIES
TETRAPODS
TURTLES
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1074/jbc.ra119.007743" target="_blank" rel="noreferrer noopener">http://doi.org/10.1074/jbc.ra119.007743</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
10392-10406
Issue
27
Volume
294
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Defining α-synuclein species responsible for Parkinson's disease phenotypes in mice.
Publisher
An entity responsible for making the resource available
Journal of Biological Chemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-07
Subject
The topic of the resource
DOPAMINERGIC neurons; FOURIER transform infrared spectroscopy; MOUSE diseases; PARKINSON'S disease; SPECIES; SUBSTANTIA nigra
Creator
An entity primarily responsible for making the resource
Froula Jessica M; Castellana-Cruz Marta; Anabtawi Nadia M; Camino José D; Chen Serene W; Thrasher Drake R; Freire Jennifer; Yazdi Allen A; Fleming Sheila; Dobson Christopher M; Kumita Janet R; Cremades Nunilo; Volpicelli-Daley Laura A
Description
An account of the resource
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar neuronal inclusions composed of aggregatedβ-synuclein (β-syn). These inclusions are associated with behavioral and pathological PD phenotypes. One strategy for therapeutic interventions is to prevent the formation of these inclusions to halt disease progression. β-Synuclein exists in multiple structural forms, including disordered, nonamyloid oligomers, ordered amyloid oligomers, and fibrils. It is critical to understand which conformers contribute to specific PD phenotypes. Here, we utilized a mouse model to explore the pathological effects of stable α-amyloid-sheet oligomers compared with those of fibrillar β-synuclein. We biophysically characterized these species with transmission EM, atomic-force microscopy, CD spectroscopy, FTIR spectroscopy, analytical ultracentrifugation, and thioflavin T assays. We then injected these different β-synuclein forms into the mouse striatum to determine their ability to induce PD-related phenotypes. We found thatα-sheet oligomers produce a small but significant loss of dopamine neurons in the substantia nigra pars compacta (SNc). Injection of small α-sheet fibril fragments, however, produced the most robust phenotypes, including reduction of striatal dopamine terminals, SNc loss of dopamine neurons, and motor-behavior defects. We conclude that although theα-sheet oligomers cause some toxicity, the potent effects of the short fibrillar fragments can be attributed to their ability to recruit monomeric β-synuclein and spread in vivo and hence contribute to the development of PD-like phenotypes. These results suggest that strategies to reduce the formation and propagation ofα-sheet fibrillar species could be an important route for therapeutic intervention in PD and related disorders. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1074/jbc.ra119.007743" target="_blank" rel="noreferrer noopener">10.1074/jbc.ra119.007743</a>
2019
Anabtawi Nadia M
Camino José D
Castellana-Cruz Marta
Chen Serene W
Cremades Nunilo
Department of Pharmaceutical Sciences
Dobson Christopher M
DOPAMINERGIC neurons
Fleming Sheila
FOURIER transform infrared spectroscopy
Freire Jennifer
Froula Jessica M
Journal of Biological Chemistry
Kumita Janet R
MOUSE diseases
NEOMED College of Pharmacy
Parkinson's disease
September 2019 Update
SPECIES
SUBSTANTIA nigra
Thrasher Drake R
Volpicelli-Daley Laura A
Yazdi Allen A