1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
387-407
Issue
3
Volume
404
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Dublin Core
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Title
A name given to the resource
Immunohistochemistry and spinal projections of the reticular formation in the northern leopard frog, Rana pipiens
Publisher
An entity responsible for making the resource available
Journal of Comparative Neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-02
Subject
The topic of the resource
american opossum; amphibian; brain-stem; central-nervous-system; descending; enkephalin; intermediolateral cell column; Neurosciences & Neurology; pathways; reticulospinal; serotonin; somatostatin; somatostatin-immunoreactive; stem reticulospinal nuclei; structures; substance P; substance-p-like; tyrosine-hydroxylase; ventral medulla-oblongata; Zoology
Creator
An entity primarily responsible for making the resource
Adli D S H; Stuesse S L; Cruce W L R
Description
An account of the resource
Over 30 nuclei have been identified in the reticular formation of rats, but only a small number of distinct reticular nuclei have been recognized in frogs. We used immunohistochemistry, retrograde tracing, and cell morphology to identify nuclei within the brainstem of Rana pipiens. FluoroGold was injected into the spinal cord, and, in the same frogs, antibodies to enkephalin, substance P, somatostatin, and serotonin were localized in adjacent sections. We identified many previously unrecognized reticular nuclei. The rhombencephalic reticular formation contained reticularis (r.) dorsalis; r. ventralis, pars alpha and pars beta; r. magnocellularis; r. parvocellularis; r. gigantocellularis; r. paragigantocellularis lateralis and dorsalis; r. pontis caudalis, pars alpha and pars beta; nucleus visceralis secundarius; r. pontis oralis, pars medialis and pars lateralis; raphe obscurus; raphe pallidus; raphe magnus; and raphe pontis. The mesencephalic reticular formation contained locus coeruleus-subcoeruleus, r. cuneiformis, r. subcuneiformis, raphe dorsalis-raphe centralis superior, and raphe linearis. Thus, the reticular formation of frog, which is an anamniote, is organized complexly and is similar to the reticular formation in amniotes. Because many of these nuclei may be homologous to reticular nuclei in mammals, we used mammalian terminology for frog reticular nuclei. (C) 1999 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1999
Adli D S H
american opossum
amphibian
brain-stem
central-nervous-system
Cruce W L R
descending
Enkephalin
intermediolateral cell column
Journal Article or Conference Abstract Publication
Journal of Comparative Neurology
Neurosciences & Neurology
pathways
reticulospinal
serotonin
somatostatin
somatostatin-immunoreactive
stem reticulospinal nuclei
structures
Stuesse S L
SUBSTANCE P
substance-p-like
tyrosine-hydroxylase
ventral medulla-oblongata
Zoology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0165-1838(96)00091-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0165-1838(96)00091-4</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
257-263
Issue
3
Volume
61
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Comparison of inotropic and chronotropic effects of vasoactive intestinal peptide in isolated dog atria
Publisher
An entity responsible for making the resource available
Journal of the Autonomic Nervous System
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
adenylate-cyclase; anesthetized dogs; atrium; autonomic nervous system; cardiac; conscious dogs; contractile force; heart rate; heart rate; isoproterenol; neuropeptide; neuropeptides; Neurosciences & Neurology; parasympathetic; performance; polypeptide; receptor; receptors; Substance P; vip
Creator
An entity primarily responsible for making the resource
Wallick D W; Stuesse S L
Description
An account of the resource
The positive chronotropic and inotropic effects of vasoactive intestinal peptide, VIP, were studied in an isolated canine right atrial preparation, Atria were removed, maintained in a bath, and perfused with Tyrode's solution. Contractile force and atrial depolarization were measured, VIP (18.8-600 pmol) was injected into a cannulated sinoatrial nodal artery and dose response curves were obtained. The mean EC(50) was similar for the inotropic and the chronotropic responses (136 and 144 pmol, respectively). Time courses of the onset and of recovery from the responses were measured. Times for onset of VIP effects were similar but, once the effect was initiated, rate of development of the response and recovery time from the responses were dose dependent, The increases in atrial rate lasted two to four times longer than did the increases in contractile force. Recovery from the chronotropic and inotropic responses to VIP differ, suggesting that the intracellular responses are coupled differently to the receptors. The responses to VIP were compared to those of 100 pmol isoproterenol, another positive chronotropic and inotropic agent. Isoproterenol was a slightly more potent chronotropic and inotropic agent than VIP. Desensitization of the responses was determined. Repeated exposures to VIP decreased the chronotropic response but not the inotropic response to VIP. There was no significant decrease in responsiveness to isoproterenol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0165-1838(96)00091-4" target="_blank" rel="noreferrer noopener">10.1016/s0165-1838(96)00091-4</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1996
adenylate-cyclase
anesthetized dogs
atrium
autonomic nervous system
Cardiac
conscious dogs
contractile force
Heart Rate
isoproterenol
Journal Article
Journal of the Autonomic Nervous System
neuropeptide
neuropeptides
Neurosciences & Neurology
parasympathetic
Performance
polypeptide
Receptor
Receptors
Stuesse S L
SUBSTANCE P
VIP
Wallick D W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1365-2680.2001.00214.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1365-2680.2001.00214.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
101-112
Issue
2
Volume
21
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Dublin Core
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Title
A name given to the resource
Changes of the responses of single sympathetic ganglionic neurones to substance P following desensitization
Publisher
An entity responsible for making the resource available
Journal of Autonomic Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-04
Subject
The topic of the resource
adenylate-cyclase; binding; cells; desensitization; G protein; inhibition; k+ current; kinase-c; M current; muscarine; Neurosciences & Neurology; Pharmacology & Pharmacy; phosphorylation; protein alpha-subunits; receptor; rgs proteins; Substance P
Creator
An entity primarily responsible for making the resource
Simmons M A
Description
An account of the resource
1 The neuropeptide substance P (SP) exerts an excitatory effect on sympathetic neurones by inhibiting a time- and voltage-dependent potassium current. During prolonged application of SP, the response desensitizes. The changes in kinetics of the SP response in single neurones after desensitization have been studied in an attempt to gain some insight as to the molecular mechanism of desensitization in live, functioning neurones. 2 Desensitization to SP resulted in subsequent SP responses being smaller, but the time course was unchanged in desensitized cells compared with non-desensitized cells. 3 Experimental manipulations were performed to decrease receptor and G protein function for comparison to desensitization. Intracellular application of GDP betaS, to decrease G protein function, led to successive responses to agonist becoming smaller and slower. When functional muscarinic receptors were decreased by extracellular application of propylbenzilylcholine mustard (PrBCM), the response to muscarine became smaller, but the time course was unchanged compared with the change in time course produced by PrBCM vehicle alone. 4 The results have also been compared with simulations from a mathematical model of drug-receptor-G protein interactions. Under a constrained set of conditions, the model predicts that decreasing the size of the G protein pool will decrease both the magnitude and the time course of the response to agonist. Decreasing receptor levels results in a more efficient decrease in the magnitude of the response but no change in the time course of the response. 5 These data provide evidence that desensitization of the response to SP in single neurones results from a decrease in functional receptors.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1365-2680.2001.00214.x" target="_blank" rel="noreferrer noopener">10.1046/j.1365-2680.2001.00214.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
adenylate-cyclase
Binding
Cells
Desensitization
G protein
inhibition
Journal Article
Journal of Autonomic Pharmacology
k+ current
kinase-c
M current
muscarine
Neurosciences & Neurology
Pharmacology & Pharmacy
Phosphorylation
protein alpha-subunits
Receptor
rgs proteins
Simmons M A
SUBSTANCE P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.peptides.2008.08.002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.peptides.2008.08.002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1919-1929
Issue
11
Volume
29
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characterization of a conformationally sensitive TOAC spin-labeled substance P
Publisher
An entity responsible for making the resource available
Peptides
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-11
Subject
The topic of the resource
activation; adrenergic-receptor; agonist; amino-acid; binding-site; Biochemistry & Molecular Biology; Endocrinology & Metabolism; EPR; ESR; GPCR; neurokinin-1; nk-1; peptide-synthesis; Pharmacology & Pharmacy; protein-coupled-receptors; receptor; Substance P; tachykinin nk1 receptor; TOAC spin label
Creator
An entity primarily responsible for making the resource
Shafer A M; Nakaie C R; Deupi X; Bennett V J; Voss J C
Description
An account of the resource
To probe the binding of a peptide agonist to a G-protein coupled receptor in native membranes, the spin-labeled amino acid analogue 4-amino-4-carboxy-2,2,6,6-tetramethyl-piperidino-1-oxyl (TOAC) was substituted at either position 4 or 9 within the substance P peptide (RPKPQQFFGLM-NH2), a potent agonist of the neurokinin-1 receptor. The affinity of the 4-TOAC analog is comparable to the native peptide while the affinity of the 9-TOAC derivative is similar to 250-fold lower. Both peptides activate receptor signaling, though the potency of the 9-TOAC peptide is substantially lower. The utility of these modified ligands for reporting conformational dynamics during the neurokinin-1 receptor activation was explored using EPR spectroscopy, which can determine the real-time dynamics of the TOAC nitroxides in solution. While the binding of both the 4-TOAC substance P and 9-TOAC substance P peptides to isolated cell membranes containing the neurokinin-1 receptor is detected, a bound signal for the 9-TOAC peptide is only obtained under conditions that maintain the receptor in its high-affinity binding state. In contrast, 4-TOAC substance P binding is observed by solution EPR under both low- and high-affinity receptor states, with evidence of a more strongly immobilized peptide in the presence of GDP. In addition, to better understand the conformational consequences of TOAC substitution into substance P as it relates to receptor binding and activation, atomistic models for both the 4- and 9-TOAC versions of the peptide were constructed, and the molecular dynamics calculated via simulated annealing to explore the influence of the TOAC substitutions on backbone structure. (C) 2008 Elsevier Inc. All rights reserved.
Identifier
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<a href="http://doi.org/10.1016/j.peptides.2008.08.002" target="_blank" rel="noreferrer noopener">10.1016/j.peptides.2008.08.002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2008
activation
adrenergic-receptor
agonist
amino-acid
Bennett V J
binding-site
Biochemistry & Molecular Biology
Deupi X
Endocrinology & Metabolism
EPR
ESR
GPCR
Journal Article
Nakaie C R
neurokinin-1
nk-1
peptide-synthesis
Peptides
Pharmacology & Pharmacy
protein-coupled-receptors
Receptor
Shafer A M
SUBSTANCE P
tachykinin nk1 receptor
TOAC spin label
Voss J C
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0149-7634(05)80228-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0149-7634(05)80228-3</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
21-41
Issue
1
Volume
17
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Title
A name given to the resource
TRENDS IN PLACE PREFERENCE CONDITIONING WITH A CROSS-INDEXED BIBLIOGRAPHY, 1957-1991
Publisher
An entity responsible for making the resource available
Neuroscience and Biobehavioral Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993
Subject
The topic of the resource
1-17 induces reward; Behavioral Sciences; beta-endorphin; brain-stimulation; conditioned place preference; drug affect; ethanol; mesolimbic dopamine system; motivational properties; Neurosciences & Neurology; nucleus-accumbens; place approach; positive reinforcing properties; rats; rewarding; self-administered; Substance P; ventral tegmental area
Creator
An entity primarily responsible for making the resource
Schechter M D; Calcagnetti D J
Description
An account of the resource
The purpose of this work is to present a perspective of the conditioned place preference (CPP) test by offering an overview of the empirical research from 1957-1991. The intent is not to extensively analyze the controversies inherent to any behavioral technique but rather to present a survey of research using a descriptive statistics approach to explore topical issues. The objectives of this work are three-fold: (a) to provide an exhaustive bibliography of the CPP literature including articles, journal abstracts, book chapters and critical reviews; (b) to provide a cross-index of identified key words/drugs tested; and (c) to give an overview of selected procedural issues underlying CPP testing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0149-7634(05)80228-3" target="_blank" rel="noreferrer noopener">10.1016/s0149-7634(05)80228-3</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1-17 induces reward
1993
Behavioral Sciences
beta-endorphin
brain-stimulation
Calcagnetti D J
conditioned place preference
drug affect
ETHANOL
Journal Article
mesolimbic dopamine system
motivational properties
Neuroscience and biobehavioral reviews
Neurosciences & Neurology
nucleus-accumbens
place approach
positive reinforcing properties
Rats
rewarding
Schechter M D
self-administered
SUBSTANCE P
ventral tegmental area
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/08990220020021366</a>
Pages
66–75
Issue
1
Volume
18
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of aging on the substance P receptor, NK–1, in the spinal cord of rats with peripheral nerve injury.
Publisher
An entity responsible for making the resource available
Somatosensory & Motor Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-01-16
Subject
The topic of the resource
ANIMAL models for aging; INJURIES to the peripheral nervous system; SPINAL cord injuries; SUBSTANCE P
Creator
An entity primarily responsible for making the resource
Cruce William L R; Lovell John A; Crisp Terriann; Stuesse Sherry L
Description
An account of the resource
Substance P (SP) levels in the spinal cords of very old rats are less than the levels in younger rats (Bergman et al., 1996). After injury to a peripheral nerve in young rats, immunoreactivity (ir) to the SP receptor, NK-1 (neurokinin-1), increases in the spinal cord ipsilateral to the injury and the increases are correlated with the development of thermal hyperalgesia (Goff et al., 1998). Thus we postulated that aged rats might display an increased sensitivity to thermal stimulation before peripheral nerve injury and that they might respond differently to injury than do younger rats. To test this hypothesis, we used the Bennett and Xie model (1988) of chronic constriction injury (CCI) to the sciatic nerve to induce a neuropathic pain condition. We investigated the effect of age on changes in NK-1 ir in superficial layers of the dorsal horn and on numbers of NK ir cells in deeper laminae at the L4-L5 levels of the spinal cord after CCI. NK-1 receptors were tagged immunohistochemically and their distribution quantified by use of computer-assisted image analysis. NK-1 ir changes were related to alterations in thermal and tactile sensitivity that developed after CCI in young, mature and aged (4-6, 14-16, and 24-26 months) Fischer F344 BNF1 hybrid rats. No differences in thermal or tactile sensitivity of young and aged rats were seen in the absence of nerve injury. After injury, aged rats developed thermal hyperalgesia and tactile allodynia more slowly than did the younger rats. NK-1 receptor ir and numbers of NK-1 ir cells in the dorsal horn increased with time post-injury in all three groups. NK-1 ir increases were correlated with the development of thermal hyperalgesia in those rats that displayed hyperalgesia. However, some rats developed an increased threshold to thermal stimuli (analgesia) and that also was correlated with increases in NK-1 ir. Thus NK-1 ir extent, while correlated with thermal sensitivity in the absence of injury, is not a specific marker for disturbances in one particular sensory modality; rather it increases with peripheral nerve injury per se. [ABSTRACT FROM AUTHOR]
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/08990220020021366" target="_blank" rel="noreferrer noopener">10.1080/08990220020021366</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
ANIMAL models for aging
Crisp Terriann
Cruce William L R
INJURIES to the peripheral nervous system
Lovell John A
Somatosensory & motor research
Spinal Cord Injuries
Stuesse Sherry L
SUBSTANCE P