1
40
7
-
Text
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URL Address
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/ijms21207472</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Issue
20
Volume
21
ISSN
1422-0067 1422-0067
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<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3390/ijms21207472</a>
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Update Year & Number
October 2020 List
NEOMED College
NEOMED College of Pharmacy
NEOMED College of Graduate Studies
NEOMED Department
Department of Pharmacy Practice
Department of Pharmaceutical Sciences
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Early pro-inflammatory remodeling of HDL proteome in a model of diet-induced obesity: 2H2O-metabolic labeling-based kinetic approach.
Publisher
An entity responsible for making the resource available
International Journal of Molecular Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-10-10
Subject
The topic of the resource
inflammation; NAFLD; proteome dynamics; dyslipidemia; insulin resistance; diet-induced obesity; acute-phase proteins; high-density lipoprotein; high-fat diet
Creator
An entity primarily responsible for making the resource
Sadana P;Lin Li;Aghayev M;Ilchenko S;Kasumov T
Description
An account of the resource
Mice fed a high-fat diet for 12 weeks or longer develop hyperglycemia, insulin resistance, dyslipidemia, and fatty liver. Additionally, a high-fat diet induces inflammation that remodels and affects the anti-inflammatory and antiatherogenic property of the high-density lipoprotein (HDL). However, the precise time course of metabolic disease progression and HDL remodeling remains unclear. Short-term (four weeks) high-fat feeding (60% fat calories) was performed in wild-type male C57BL/6J mice to gain insights into the early metabolic disease processes in conjunction with a HDL proteome dynamics analysis using a heavy water metabolic labeling approach. The high-fat diet-fed mice developed hyperglycemia, impaired glucose tolerance, hypercholesterolemia without hypertriglyceridemia or hepatic steatosis. A plasma HDL proteome dynamics analysis revealed increased turnover rates (and reduced half-lives) of several acute-phase response proteins involved in innate immunity, including complement C3 (12.77 ± 0.81 vs. 9.98 ± 1.20 h, p < 0.005), complement factor B (12.71 ± 1.01 vs. 10.85 ± 1.04 h, p < 0.05), complement Factor H (19.60 ± 1.84 vs. 16.80 ± 1.58 h, p < 0.05), and complement factor I (25.25 ± 1.29 vs. 19.88 ± 1.50 h, p < 0.005). Our findings suggest that an early immune response-induced inflammatory remodeling of the plasma HDL proteome precedes the diet-induced steatosis and dyslipidemia.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3390/ijms21207472" target="_blank" rel="noreferrer noopener">10.3390/ijms21207472</a>
Format
The file format, physical medium, or dimensions of the resource
journalArticle
2020
acute-phase proteins
Aghayev M
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
diet-induced obesity
dyslipidemia
high-density lipoprotein
High-fat diet
Ilchenko S
Inflammation
Insulin Resistance
International journal of molecular sciences
journalArticle
Kasumov T
Lin Li
NAFLD
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
October 2020 List
Proteome dynamics
Sadana P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
37
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Dublin Core
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Title
A name given to the resource
Inhibition Of Angiopoietin-like 3 Expression Is A Potential Mechanism Of Activation Of Lipoprotein Lipase And Of Lipid Lowering By Metformin
Publisher
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Arteriosclerosis Thrombosis and Vascular Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
Cardiovascular System & Cardiology; Drugs; Hematology; Hyperlipidemia; Lipases
Creator
An entity primarily responsible for making the resource
Lin L; Burke J R; Geldenhuys W J; Sadana P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Arteriosclerosis Thrombosis and Vascular Biology
Burke J R
Cardiovascular System & Cardiology
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drugs
Geldenhuys W J
Hematology
Hyperlipidemia
Journal Article or Conference Abstract Publication
Lin L
Lipases
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
867A-868A
Volume
62
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Title
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Genetic Ablation Of Mitoneet Alleviates Alcoholic Steatosis/steahepatitis In Mice
Publisher
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Hepatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-10
Subject
The topic of the resource
Gastroenterology & Hepatology
Creator
An entity primarily responsible for making the resource
Jogasuria A; Geldenhuys W J; Wang J Y; Hu X D; Lee K; Sadana P; Wu J S; You M
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Gastroenterology & Hepatology
Geldenhuys W J
Hepatology
Hu X D
Jogasuria A
Journal Article or Conference Abstract Publication
Lee K
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P
Wang J Y
Wu J S
You M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
26
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Title
A name given to the resource
Thyroid hormone (T3) regulates lipoprotein metabolism via induction of Angiopoeitin-like 4 (ANGPTL4) in human hepatoma cell line
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Talasila P K; Sadana P
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2012
Biochemistry & Molecular Biology
Cell Biology
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Faseb Journal
Journal Article
Life Sciences & Biomedicine - Other
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P
Talasila P K
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Issue
1
Volume
28
Search for Full-text
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Dublin Core
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Title
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Identification and characterization of a novel small molecule agonist of lipoprotein lipase by random screening
Publisher
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Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Sadana P; Aring D; Burke J; Geldenhuys W
Identifier
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n/a
Format
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Journal Article
2014
Aring D
Biochemistry & Molecular Biology
Burke J
Cell Biology
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Faseb Journal
Geldenhuys W
Journal Article
Life Sciences & Biomedicine - Other
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1-1
Volume
29
Search for Full-text
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Dublin Core
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Title
A name given to the resource
Alcohol Induces Angiopoeitin like-3 (ANGPTL3) in the Liver: Implications for Alcohol Induced Hypertriglyceridemia
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Sadana P; Burke J; Jogasuria A; Darvesh A; Geldenhuys W; Wu J S; You M
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2015
Biochemistry & Molecular Biology
Burke J
Cell Biology
Darvesh A
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Faseb Journal
Geldenhuys W
Jogasuria A
Journal Article
Life Sciences & Biomedicine - Other
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Sadana P
Topics
Wu J S
You M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1021/cb200092v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1021/cb200092v</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1096-1106
Issue
10
Volume
6
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Title
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Similarities and Differences between Two Modes of Antagonism of the Thyroid Hormone Receptor
Publisher
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Acs Chemical Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-10
Subject
The topic of the resource
androgen receptor; Biochemistry & Molecular Biology; coactivator binding; estrogen receptor; gene-expression; growth-hormone; hepatoma-cell line; hepg2; liver; nuclear receptor; small-molecule inhibitors
Creator
An entity primarily responsible for making the resource
Sadana P; Hwang J Y; Attia R R; Arnold L A; Neale G; Guy R K
Description
An account of the resource
Thyroid hormone (T3) mediates diverse physiological functions including growth, differentiation, and energy homeostasis through the thyroid hormone receptors (TR). The TR binds DNA at specific recognition sequences in the promoter regions of their target genes known as the thyroid, hormone response elements (TREs). Gene expression at TREs regulated by TRs is mediated by coregulator recruitment to the DNA bound receptor. This TR-coregulator interaction controls transcription of target genes by multiple mechanisms including covalent histone modifications and chromatin remodeling. Our previous studies identified a beta-aminoketone as a potent inhibitor of the TR-coactivator interaction. We describe here the activity of one of these inhibitors in modulating effects of T3 signaling in comparison to an established ligand-competitive inhibitor of TR, NH-3. The beta-aminoketone was found to reverse thyroid hormone induced gene expression by inhibiting coactivator recruitment at target gene promoters, thereby regulating downstream effects of thyroid hormone. While mimicking the downstream effects of NH-3 at the molecular level, the beta-aminoketone affects only a subset of the thyroid responsive signaling network. Thus antagonists directed to the coregulator binding site have distinct pharmacological properties relative to ligand-based antagonists and may provide complementary activity in vivo.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1021/cb200092v" target="_blank" rel="noreferrer noopener">10.1021/cb200092v</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2011
Acs Chemical Biology
androgen receptor
Arnold L A
Attia R R
Biochemistry & Molecular Biology
coactivator binding
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
estrogen receptor
gene-expression
growth-hormone
Guy R K
hepatoma-cell line
hepg2
Hwang J Y
Journal Article
Liver
Neale G
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
Nuclear Receptor
Sadana P
small-molecule inhibitors