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Transcriptional activation of the cholesterol 7 alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors

The gene encoding cholesterol 7 alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the…

Transcriptional regulation of the cholesterol 7 alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors bound to the bile acid response elements (BARE)

Tags: 1999, activation, Book/Monograph, Chiang J Y L, Crestani M, identification, promoter, Sadeghpour A, Stroup D

A possible interaction between different signal transduction pathways in the regulation of cholesterol 7 alpha-hydrocylase gene (CYP7A)

Tags: 1997, Biochemistry & Molecular Biology, Cell Biology, Chiang J Y L, Crestani M, Faseb Journal, Galli G, Journal Article, Life Sciences & Biomedicine - Other, Sadeghpour A, Topics

Identification of regulatory elements involved in insulin and phorbol 12-myristate 13-acetate (PMA) effect on the cholesterol 7 alpha-hydroxylase (CYP7A1) gene expression

Tags: 1999, Biochemistry & Molecular Biology, Cell Biology, Chiang J Y L, Crestani M, Faseb Journal, Journal Article, Life Sciences & Biomedicine - Other, Sadeghpour A, Topics

Transcriptional activation of the cholesterol 7alpha-hydroxylase gene (CYP7A) by nuclear hormone receptors.

The gene encoding cholesterol 7alpha-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the…

Tags: *Receptors, *Transcriptional Activation, 1998, Animals, Base Sequence, Bile Acids and Salts/biosynthesis, Chiang J Y, Cholesterol 7-alpha-Hydroxylase/*genetics, COUP Transcription Factor II, COUP Transcription Factors, Crestani M, Cultured, Cytoplasmic and Nuclear/*physiology, Department of Integrative Medical Sciences, DNA-Binding Proteins/metabolism, DNA/metabolism, Galli G, Genes, Genetic, Hepatocyte Nuclear Factor 4, Hormones/*physiology, Journal of lipid research, Luciferases/genetics, Molecular Sequence Data, Mutagenesis, NEOMED College of Medicine, Nucleic Acid, Oligonucleotide Probes/metabolism, Phosphoproteins/metabolism, Promoter Regions, Rats, Receptors, Repetitive Sequences, Reporter, Retinoic Acid/metabolism, Retinoid X Receptors, Sadeghpour A, Site-Directed, Steroid, Stroup D, Transcription Factors/metabolism, Tumor Cells

The opposing effects of retinoic acid and phorbol esters converge to a common response element in the promoter of the rat cholesterol 7 alpha-hydroxylase gene (CYP7A).

The activity of the rat CYP7A/luciferase reporter gene was increased five-fold by all-trans retinoic acid (atRA) or 9-cis retinoic acid (9cRA) in transient transfection assay in HepG2 cells. Cotransfection with retinoid X receptor (RXR) stimulated…

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