1
40
15
-
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
275
Issue
1, SI
Volume
35
ISSN
0884-0431
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January 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Anatomy & Neurobiology
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Title
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Altered endochondral ossification and primary cilia in a hypothyroid swine model
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Journal Of Bone and Mineral Research
Date
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2020
2020-11
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Mohrman A; Reber E; Safadi F; Adamczyk M
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Adamczyk M
Department of Anatomy & Neurobiology
January 2021 List
Journal of Bone and Mineral Research
journalArticle
Mohrman A
NEOMED College of Medicine
NEOMED Student Publications
Reber E
Safadi F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener">http://doi.org/</a>
Pages
107
Issue
1, SI
Volume
35
ISSN
0884-0431
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January 2021 List
NEOMED College
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Department of Anatomy & Neurobiology
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Title
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A novel regulatory role of TRAPPC9 in osteoarthritis
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Journal Of Bone and Mineral Research
Date
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2020
2020-11
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Hussein N; Safadi F
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<a href="http://doi.org/" target="_blank" rel="noreferrer noopener"></a>
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journalArticle
2020
Department of Anatomy & Neurobiology
Hussein N
January 2021 List
Journal of Bone and Mineral Research
journalArticle
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED Student Publications
Safadi F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09824" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fasebj.2020.34.s1.09824</a>
Issue
1
Volume
34
ISSN
0892-6638
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September 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Department of Anatomy & Neurobiology
Affiliated Hospital
Akron Children's Hospital
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Title
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Semaphorin-3F, a potential biomarker for lymphatic anomalies and bone cell function
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Faseb Journal
Date
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2020
2020-04
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Solorzano E;Kelly M;Safadi F
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Lymphatic anomalies (LA) are rare conditions characterized by abnormal vascularization of lymphatic vessels (lymphangiogenesis). Gorham‐Stout Disease (GSD) is an aggressive type of LA which invades cortical bone and makes it “disappear”. There is little evidence elucidating the etiology of GSD and its osteolytic tendencies due to the rarity of the disease. In addition, there are no biomarkers capable of predicting GSD progression or treatment outcome. Normal bone does not have lymphatic vessels. It is believed that in GSD lymphatic endothelial cells (LEC) undergo genetic changes early in development that facilitate their migration and vessel formation in bone. LECs and their secretome content (lymph) are likely both crucial to lymphatic migration into bone and the cortical destruction seen in GSD. In this study, we focused on the LEC secretome with the goal of identifying proteins capable of modifying LEC and bone cell interactions. We initially assessed the effects of normal LEC conditioned media (LEC‐CM) on bone cell differentiation and function in vitro, and found that LEC‐CM stimulates osteoclast differentiation. Next, we subjected LEC‐CM to mass spectrometry and over 500 proteins were identified; we focused specifically on Semaphorin‐3F (SEMA3F) as SEMA3F effectively inhibits lymphangiogenesis in part, by competing with vascular endothelial growth factor‐C (VEGF‐C), for binding to the neuropilin‐2 receptor. We measured mRNA expression of both SEMA3F and VEGF‐C in untreated and Rapamycin treated LECs, a clinically effective therapy for patients with lymphatic anomalies. SEMA3F mRNA expression was upregulated while VEGF‐C was downregulated in Rapamycin treated versus untreated LEC cultures. We next assessed the effects of exogenous SEMA3F on LEC viability and on osteoblast differentiation and function. We found that SEMA3F reduced LEC viability in a dose‐dependent fashion. In addition, SEMA3F inhibited osteoblast differentiation as measured by alkaline‐phosphatase activity and matrix mineralization independent of its effects on osteoblast viability or proliferation. Experiments are currently underway to determine the expression/localization of SEMA3F, VEGF‐C and neuropilin‐2 in lymphatic anomalies (LA) tissues obtained from pediatric patients at our facility. We expect that SEMA3F expression will be downregulated while VEGF‐C will be upregulated in LA compared to normal lymphatics. In summary, our data suggest that SEMA3F might be a possible biomarker for patient with LA conditions or contributes to their pathogenesis.
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09824" target="_blank" rel="noreferrer noopener">10.1096/fasebj.2020.34.s1.09824</a>
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journalArticle
2020
Akron Children's Hospital
Department of Anatomy & Neurobiology
Faseb Journal
journalArticle
Kelly M
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
Safadi F
September 2020 List
Solorzano E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09750" target="_blank" rel="noreferrer noopener">http://doi.org/10.1096/fasebj.2020.34.s1.09750</a>
Issue
1
Volume
34
ISSN
0892-6638
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September 2020 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Science
Department of Anatomy & Neurobiology
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L-plastin, a novel regulator of microglial activation in parkinsons disease
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Faseb Journal
Date
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2020
2020-04
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Budge K;Richardson JR;Safadi F
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An account of the resource
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease worldwide behind Alzheimer’s disease. One prominent feature of PD is the marked loss of dopaminergic and motor dysfunction. Currently, there are no therapies to effectively slow disease progression. Neuroinflammation is a major contributing factor in neurodegeneration diseases including PD. Microglia, a type of glial cell, are primary regulators of neuroinflammation and these cells are capable of assuming activation states ranging from inflammatory to anti‐inflammatory and reparative. Thus methods to combat microglial inflammation or promote microglial anti‐inflammatory and reparative effects show promise as treatments to slow neurodegeneration. L‐plastin (LPL) is an acting bundling protein and other research has shown that LPL plays a role in osteoclast function, T‐cell activation, and it may be involved in the NLRP3 inflammasome activation in macrophages. It has been shown in osteoclasts, that LPL phosphorylation at serine 5 plays a role in sealing zone formation. Using a peptide inhibitor to block phosphorylation of serine 5 on LPL prevented sealing zone formation and inhibited osteoclast‐mediated bone resorption. Given the evidence that LPL may play a role in inflammasome activation in macrophages, we investigated if LPL may play a role in microglial activation. To assess the function of LPL in the microglial inflammatory response, we utilized qPCR, Western blot, and immunofluorescence techniques. We show here that lipopolysaccharide (LPS) treatment induces LPL phosphorylation at serine 5, as well as increased Lcp1 mRNA expression. Furthermore, using a TAT‐fused peptidomimetic inhibitor of LPL phosphorylation significantly reduced LPS‐induced inflammatory gene (Il‐1b, Il‐6, Tnfa) expression. For this study, an acute 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) mouse model was also used. Male (10‐week‐old) C57BL/6N mice were treated with four injections (one every two hours) of either saline or 15mg/kg of MPTP. Mice were then sacrificed two days after the last injection and striatum and hindbrain were isolated. Two days after MPTP treatment is when peak inflammation occurs in the brain. We found that Lcp1 mRNA expression was significantly increased in the striatum of MPTP‐treated mice compared to saline‐treated mice. These results suggest that LPL may play a role in the microglial inflammatory response, and that LPL inhibition may be a novel way to combat neuroinflammation and neurodegeneration. We are currently staining for phosphorylated LPL in the microglia of MPTP treated mice. Furthermore, we have obtained LPL KO mice to assess the in vivo function of LPL in mouse models of PD.
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<a href="http://doi.org/10.1096/fasebj.2020.34.s1.09750" target="_blank" rel="noreferrer noopener">10.1096/fasebj.2020.34.s1.09750</a>
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journalArticle
2020
Budge K
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Faseb Journal
journalArticle
NEOMED College of Medicine
NEOMED College of Pharmacy
Richardson JR
Safadi F
September 2020 List
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ekir.2020.03.025" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ekir.2020.03.025</a>
Pages
980-990
Issue
7
Volume
5
ISSN
2468-0249
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Internal Medicine
Department of Anatomy & Neurobiology
NEOMED Student Publications
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Title
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An overview of rickets in children
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Kidney International Reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-07
Subject
The topic of the resource
prevention; vitamin D; mutations; animal-model; phosphate; chronic kidney disease; phosphorus; d-receptor; d-resistant rickets; hereditary hypophosphatemic rickets; hypocalcemia; hypophosphatemia; targeted ablation; vitamin-d-deficiency; x-linked hypophosphatemia
Creator
An entity primarily responsible for making the resource
Chanchlani R; Nemer P; Sinha R; Nemer L; Krishnappa V; Sochett E; Safadi F; Raina R
Description
An account of the resource
Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phos- phate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based on phosphate or calcium levels: phosphopenic and calcipenic. Knowledge of cate- gorization of the type of rickets is essential for prompt diagnosis and proper management. Nutritional rickets is a preventable disease through adequate intake of vitamin D through both dietary and sunlight exposure. There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D- dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor -23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. An important development has been the introduction of burosumab, a human monoclonal antibody to FGF- 23, which is approved for the treatment of X -linked hypophosphatemia among children 1 year and older.
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<a href="http://doi.org/10.1016/j.ekir.2020.03.025" target="_blank" rel="noreferrer noopener">10.1016/j.ekir.2020.03.025</a>
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journalArticle
2020
animal-model
August 2020 List
Chanchlani R
Chronic kidney disease
d-receptor
d-resistant rickets
Department of Anatomy & Neurobiology
Department of Internal Medicine
hereditary hypophosphatemic rickets
hypocalcemia
hypophosphatemia
journalArticle
Kidney International Reports
Krishnappa V
mutations
Nemer L
Nemer P
NEOMED College of Medicine
NEOMED College of Medicine Student
phosphate
phosphorus
Prevention
Raina R
Safadi F
Sinha R
Sochett E
targeted ablation
Vitamin D
vitamin-d-deficiency
x-linked hypophosphatemia
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">http://doi.org/10.18632/oncotarget.27583</a>
Pages
1876–1893
Issue
20
Volume
11
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Update Year & Number
July 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED College of Pharmacy
NEOMED Department
Department of Anatomy & Neurobiology
Department of Pharmaceutical Sciences
Department of Pediatrics
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma.
Publisher
An entity responsible for making the resource available
Oncotarget
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-05
Subject
The topic of the resource
DNA methylation; neuronatin; osteosarcoma; tumor suppressor genes
Creator
An entity primarily responsible for making the resource
Saeed H; Sinha S; Mella C; Kuerbitz JS; Cales ML; Steele MA; Stanke J; Damron D; Safadi F; Kuerbitz SJ
Description
An account of the resource
The paternally imprinted neuronatin (NNAT) gene has been identified as a target of aberrant epigenetic silencing in diverse cancers, but no association with pediatric bone cancers has been reported to date. In screening childhood cancers, we identified aberrant CpG island hypermethylation in a majority of osteosarcoma (OS) samples and in 5 of 6 human OS cell lines studied but not in normal bone-derived tissue samples. CpG island hypermethylation was associated with transcriptional silencing in human OS cells, and silencing was reversible upon treatment with
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.18632/oncotarget.27583" target="_blank" rel="noreferrer noopener">10.18632/oncotarget.27583</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2020
Cales ML
Damron D
Department of Anatomy & Neurobiology
Department of Pediatrics
Department of Pharmaceutical Sciences
DNA Methylation
journalArticle
July 2020 List
Kuerbitz JS
Kuerbitz SJ
Mella C
NEOMED College of Medicine
NEOMED College of Pharmacy
neuronatin
Oncotarget
osteosarcoma
Saeed H
Safadi F
Sinha S
Stanke J
Steele MA
tumor suppressor genes
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
23
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Title
A name given to the resource
Delayed Bone Development In A Preeclampsia Mouse Model
Publisher
An entity responsible for making the resource available
Molecular Biology of the Cell
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012
Subject
The topic of the resource
Cell Biology
Creator
An entity primarily responsible for making the resource
Lababidi S L; Nakhla S; Al-Ghafiy M; Rafii A; Davisson R L; Safadi F
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n/a
Format
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Journal Article or Conference Abstract Publication
2012
Al-Ghafiy M
Cell Biology
Davisson R L
Journal Article or Conference Abstract Publication
Lababidi S L
Molecular Biology of the Cell
Nakhla S
Rafii A
Safadi F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S232-S233
Volume
32
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Title
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Gpnmb/osteoactivin Plays A Novel Role In Autophagy-mediated Osteoclast Differentiation And Function
Publisher
An entity responsible for making the resource available
Journal of Bone and Mineral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
Endocrinology & Metabolism
Creator
An entity primarily responsible for making the resource
Jaber F; Al-Adlaan A; Hussein N; Safadi F
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Al-Adlaan A
Endocrinology & Metabolism
Hussein N
Jaber F
Journal Article or Conference Abstract Publication
Journal of Bone and Mineral Research
Safadi F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.aca.2013.03.053" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.aca.2013.03.053</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
41-49
Volume
779
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Title
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Differences In Infrared Spectroscopic Data Of Connective Tissues In Transflectance And Transmittance Modes
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Analytica Chimica Acta
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-05
Subject
The topic of the resource
BaF2 window; bone; cartilage; Chemistry; collagen orientation; consequences; Fourier transform infrared imaging spectroscopy; Low-e; proteoglycan; scattering; slide; Transflectance; Transmittance; variance
Creator
An entity primarily responsible for making the resource
Hanifi A; McGoverin C; Ou Y T; Safadi F; Spencer R G; Pleshko N
Description
An account of the resource
Fourier transform infrared imaging spectroscopy (FT-IRIS) has been used extensively to characterize the composition and orientation of macromolecules in thin tissue sections. Earlier and current studies of normal and polarized FT-IRIS data have primarily used tissues sectioned onto infrared transmissive substrates, such as salt windows. Recently, the use of low-emissivity ("low-e") substrates has become of great interest because of their low cost and favorable infrared optical properties. However, data are collected in transflectance mode when using low-e slides and in transmittance mode using salt windows. In the current study we investigated the comparability of these two modes for assessment of the composition of connective tissues. FT-IRIS data were obtained in transflectance and transmittance modes from serial sections of cartilage, bone and tendon, and from a standard polymer, polymethylmethacrylate. Both non-polarized and polarized FTIR data differed in absorbance, and in some cases peak position, between transflectance and transmittance modes. However, the FT-IRIS analysis of the collagen fibril orientation in cartilage resulted in the expected zonal arrangement of fibrils in both transmittance and transflectance. We conclude that numerical comparison of FT-IRIS-derived parameters of tissue composition should account for substrate type and data collection mode, while analysis of overall tissue architecture may be more invariant between modes. (c) 2013 Elsevier B.V. All rights reserved.
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<a href="http://doi.org/10.1016/j.aca.2013.03.053" target="_blank" rel="noreferrer noopener">10.1016/j.aca.2013.03.053</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2013
Analytica Chimica Acta
BaF2 window
Bone
Cartilage
Chemistry
collagen orientation
consequences
Fourier transform infrared imaging spectroscopy
Hanifi A
Journal Article or Conference Abstract Publication
Low-e
McGoverin C
Ou Y T
Pleshko N
proteoglycan
Safadi F
Scattering
slide
Spencer R G
Transflectance
Transmittance
variance
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
253-253
Volume
33
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
TRAPPC9 Regulates BMP2-mediated Osteoblast Differentiation and Bone Regeneration through Down-Regulation of NF-kB Activation
Publisher
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Journal of Bone and Mineral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-11
Subject
The topic of the resource
Endocrinology & Metabolism
Creator
An entity primarily responsible for making the resource
Mbimba T; Sondag G; Moussa F; Safadi F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2018
Endocrinology & Metabolism
Journal Article or Conference Abstract Publication
Journal of Bone and Mineral Research
Mbimba T
Moussa F
Safadi F
Sondag G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
31
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Novel Neuroprotective Effect of Osteoactivin in Parkinson's Disease
Publisher
An entity responsible for making the resource available
Faseb Journal
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-04
Subject
The topic of the resource
Biochemistry & Molecular Biology; Cell Biology; Life Sciences & Biomedicine - Other; Topics
Creator
An entity primarily responsible for making the resource
Budge K M; Alam G; Edler M; Richardson J; Safadi F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Alam G
Biochemistry & Molecular Biology
Budge K M
Cell Biology
Edler M
Faseb Journal
Journal Article or Conference Abstract Publication
Life Sciences & Biomedicine - Other
Richardson J
Safadi F
Topics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
E9-E9
Volume
55
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characterizing the Unique Extra cellular Matrix of Bat Wing Bones
Publisher
An entity responsible for making the resource available
Integrative and Comparative Biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-04
Subject
The topic of the resource
Zoology
Creator
An entity primarily responsible for making the resource
Ball H; Clementz M; Vinyard C; Safadi F; Cooper L N
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2015
Ball H
Clementz M
Cooper L N
Integrative and comparative biology
Journal Article or Conference Abstract Publication
Safadi F
Vinyard C
Zoology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S199-S199
Volume
32
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Dublin Core
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Title
A name given to the resource
miRNA-150, a novel regulator of post-traumatic osteoarthritis
Publisher
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Journal of Bone and Mineral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-12
Subject
The topic of the resource
Endocrinology & Metabolism
Creator
An entity primarily responsible for making the resource
Al-Adlaan A; Jaber F; Hussein N; Safadi F
Identifier
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n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2017
Al-Adlaan A
Endocrinology & Metabolism
Hussein N
Jaber F
Journal Article or Conference Abstract Publication
Journal of Bone and Mineral Research
Safadi F
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
S420-S420
Volume
25
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Title
A name given to the resource
MUTATION IN OSTEOACTIVIN ENHANCES RANKL-MEDIATED SIGNALING, PROMOTING OSTEOCLAST DIFFERENTIATION AND SURVIVAL
Publisher
An entity responsible for making the resource available
Osteoporosis International
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-04
Subject
The topic of the resource
Endocrinology & Metabolism
Creator
An entity primarily responsible for making the resource
Abdelmagid S M; Sondag G; Moussa F M; Khol M; Fulp C; Safadi F
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2014
Abdelmagid S M
Endocrinology & Metabolism
Fulp C
Journal Article or Conference Abstract Publication
Khol M
Moussa F M
Osteoporosis International
Safadi F
Sondag G
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1371/journal.pone.0038359" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0038359</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
13-13
Issue
5
Volume
7
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Title
A name given to the resource
Performance of Repetitive Tasks Induces Decreased Grip Strength and Increased Fibrogenic Proteins in Skeletal Muscle: Role of Force and Inflammation
Publisher
An entity responsible for making the resource available
PLOS ONE
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-05
Subject
The topic of the resource
carpal-tunnel-syndrome; factor gene-expression; flexor tendon cells; in-vivo; lengthening contractions; necrosis-factor-alpha; rat model; Science & Technology - Other Topics; strain injury; tissue growth-factor; tnf-alpha
Creator
An entity primarily responsible for making the resource
Abdelmagid S M; Barr A E; Rico M; Amin M; Litvin J; Popoff S N; Safadi F; Barbe M F
Description
An account of the resource
Background: This study elucidates exposure-response relationships between performance of repetitive tasks, grip strength declines, and fibrogenic-related protein changes in muscles, and their link to inflammation. Specifically, we examined forearm flexor digitorum muscles for changes in connective tissue growth factor (CTGF; a matrix protein associated with fibrosis), collagen type I (Col1; a matrix component), and transforming growth factor beta 1 (TGFB1; an upstream modulator of CTGF and collagen), in rats performing one of two repetitive tasks, with or without anti-inflammatory drugs. Methodology/Results: To examine the roles of force versus repetition, rats performed either a high repetition negligible force food retrieval task (HRNF), or a high repetition high force handle-pulling task (HRHF), for up to 9 weeks, with results compared to trained only (TR-NF or TR-HF) and normal control rats. Grip strength declined with both tasks, with the greatest declines in 9-week HRHF rats. Quantitative PCR (qPCR) analyses of HRNF muscles showed increased expression of Col1 in weeks 3-9, and CTGF in weeks 6 and 9. Immunohistochemistry confirmed PCR results, and also showed greater increases of CTGF and collagen matrix in 9-week HRHF rats than 9-week HRNF rats. ELISA, and immunohistochemistry revealed greater increases of TGFB1 in TR-HF and 6-week HRHF, compared to 6-week HRNF rats. To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-alpha treatment in HRHF weeks 4-6. Both treatments attenuated HRHF-induced increases in CTGF and fibrosis by 6 weeks of task performance. Ibuprofen attenuated TGFB1 increases and grip strength declines, matching our prior results with anti-TNF alpha. Conclusions/Significance: Performance of highly repetitive tasks was associated with force-dependent declines in grip strength and increased fibrogenic-related proteins in flexor digitorum muscles. These changes were attenuated, at least short-term, by anti-inflammatory treatments.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1371/journal.pone.0038359" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0038359</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2012
Abdelmagid S M
Amin M
Barbe M F
Barr A E
carpal-tunnel-syndrome
factor gene-expression
flexor tendon cells
in-vivo
Journal Article or Conference Abstract Publication
lengthening contractions
Litvin J
necrosis-factor-alpha
PloS one
Popoff S N
rat model
Rico M
Safadi F
Science & Technology - Other Topics
strain injury
tissue growth-factor
TNF-alpha