1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
329-329
Volume
34
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Update Year & Number
March 2020 Update
NEOMED College
NEOMED College of Medicine; NEOMED College of Graduate Studies
NEOMED Department
Department of Anatomy & Neurobiology; NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A Novel Regulatory Role of TRAPPC9 in In Inflammatory Chondrocytes and Osteoarthritis
Publisher
An entity responsible for making the resource available
Journal of Bone and Mineral Research
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-12
Creator
An entity primarily responsible for making the resource
Hussein Nazar; Zepeda Ernesto Solorzano; Safadi Fayez
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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Journal Article
2019
Department of Anatomy & Neurobiology
Hussein Nazar
Journal of Bone and Mineral Research
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
NEOMED Student Publications
Safadi Fayez
Zepeda Ernesto Solorzano
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00240-019-01133-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00240-019-01133-1</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Adolescents with urinary stones have elevated urine levels of inflammatory mediators
Publisher
An entity responsible for making the resource available
Urolithiasis
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019-04
Subject
The topic of the resource
Biomarker; Cytokine; Innate immunity; Interleukin
Creator
An entity primarily responsible for making the resource
Kusumi Kirsten; Ketz John; Saxena Vijay; Spencer John David; Safadi Fayez; Schwaderer Andrew
Description
An account of the resource
Urinary stones are increasing in children, primarily during adolescence. Although urinary stones are often viewed in the context of intermittent stone events, increasing evidence indicates that stones are a metabolic process associated with chronic kidney disease and cardiovascular disease. These aforementioned stone-associated conditions may have pediatric origins. To compare urine inflammatory markers in otherwise healthy stone forming children versus matched controls. Urine samples were collected from 12 adolescents with urinary stones along with 15 controls. The levels of 30 urine cytokines were measured using a Mesoscale 30-Plex Human Cytokine panel and normalized to urine creatinine levels. Macrophage inflammatory protein 1β and interleukin 13 levels were significantly elevated in the urine of the stone forming adolescents compared to controls. Interleukin 17A was elevated in the urine of controls. This study indicates that urine levels of cytokines involved in chronic inflammation and fibrosis are elevated in urinary stone formers as early as adolescence. Because stone formers are at risk for chronic kidney disease, macrophage inflammatory protein 1β and interleukin 13 represent investigative targets.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00240-019-01133-1" target="_blank" rel="noreferrer noopener">10.1007/s00240-019-01133-1</a>
2019
Biomarker
Cytokine
Department of Pediatrics
Innate immunity
Interleukin
June 2019 Update
Ketz John
Kusumi Kirsten
NEOMED College of Medicine
Safadi Fayez
Saxena Vijay
Schwaderer Andrew
Spencer John David
urolithiasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fped.2019.00032" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2019.00032</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
32-32
Volume
7
Dublin Core
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Title
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Comparison of Risk Factors for Pediatric Kidney Stone Formation: The Effects of Sex.
Publisher
An entity responsible for making the resource available
Frontiers in pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019
Subject
The topic of the resource
pediatrics; age; sex; kidney stones; urolithiasis
Creator
An entity primarily responsible for making the resource
Schwaderer Andrew L; Raina Rupesh; Khare Anshika; Safadi Fayez; Moe Sharon M; Kusumi Kirsten
Description
An account of the resource
Background: Urinary stones are affecting more children, and pediatric stone formers have unique pathophysiology compared to adults. While adult stone formers are most frequently male, children have an age dependent sex prevalence. Under 10 years, a majority of stone formers are boys; adolescent stone formers are mostly female. Previous adult studies have shown that stone composition is influenced by the sex and age of the stone former. Thus, we hypothesize that female and male stone forming children will also have sex and age specific stone phenotypes. Methods: Retrospective chart review of a large pediatric center's stone forming children 6/1/2009 to 6/1/2016. Patients were identified by ICD 9 codes: N20, N20.1, and N20.9. Charts were reviewed for radiographic evidence of stones or documented visualized stone passage. Results: One hundred and thirty six subjects: 54 males and 82 females. Females were older, median age 14 years [interquartile range (IQR): 11, 15] vs. males' median age 12 years (IQR: 11, 14) (p < 0.01). Females had lower height z-scores, median 0.2 (IQR: -0.8, 0.8) vs. males' median 0.8 (IQR: -0.2, 1.8) (p < 0.01). Presenting symptoms were similar except flank pain affecting 39% of females vs. 22% of males (p = 0.04). Leukocyte esterase was positive in more females than males (33 vs. 4%) (p < 0.001). Males had a higher BUN/Cr ratio, mean +/- standard deviation of 19.8 +/- 6.3 vs. 16.6 +/- 6.5 in females (p = 0.01). Glomerular hyperfiltration was present in 9% of patients while 35% of patients had estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m(2). Treatment strategies and clinical course were similar except females were told to increase dietary citrate more frequently than males (21 vs. 4%) (p < 0.01). Conclusion: We have provided a novel analysis and demonstrated that low height z-score and pyuria are more common in female stone formers. We have also shown that 9% of pediatric stone formers have labs consistent with hyperfiltration. Whether high protein intake and/or chronic dehydration are associated with hyperfiltration and long-term renal function in children with kidney stones will be an area for future research.
Identifier
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<a href="http://doi.org/10.3389/fped.2019.00032" target="_blank" rel="noreferrer noopener">10.3389/fped.2019.00032</a>
2019
Age
Department of Internal Medicine
Frontiers in pediatrics
Khare Anshika
KIDNEY STONES
Kusumi Kirsten
Moe Sharon M
NEOMED College of Medicine
Pediatrics
Raina Rupesh
Safadi Fayez
Schwaderer Andrew L
sex
urolithiasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jid.2017.08.034</a>
Pages
219–227
Issue
1
Volume
138
Dublin Core
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Title
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Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Publisher
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The Journal of investigative dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Creator
An entity primarily responsible for making the resource
Yu Bing; Alboslemy Talib; Safadi Fayez; Kim Min-Ho
Description
An account of the resource
The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding of the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood. Here, using an in vivo model of cutaneous wound healing in mice, we provide evidence that GPNMB is functionally important in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by directing the M2 polarization of macrophages in acute wound healing. Furthermore, we show that GPNMB activity is impaired in a diabetic wound environment, which is associated with impaired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to the wounds of diabetic mice. Our study provides important insight into the crosstalk between macrophages and endogenous MSCs toward wound repair.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">10.1016/j.jid.2017.08.034</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Alboslemy Talib
Department of Anatomy & Neurobiology
Kim Min-Ho
NEOMED College of Medicine
Safadi Fayez
The Journal of investigative dermatology
Yu Bing
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jid.2017.08.034</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
219-227
Issue
1
Volume
138
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycoprotein Nonmelanoma Clone B Regulates the Crosstalk between Macrophages and Mesenchymal Stem Cells toward Wound Repair.
Publisher
An entity responsible for making the resource available
The Journal of investigative dermatology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-01
Subject
The topic of the resource
Humans; Male; Animals; Mice; Cell Differentiation; Wound Healing/*physiology; Macrophages/*physiology; Diabetes Mellitus; Cells; Cultured; Inbred C57BL; Animal; Disease Models; Administration; Cutaneous; Cell Communication/*physiology; Eye Proteins/administration & dosage/genetics/*physiology; Membrane Glycoproteins/administration & dosage/genetics/*physiology; Mesenchymal Stem Cells/*physiology; Recombinant Proteins/administration & dosage/genetics/metabolism; Skin/*injuries/metabolism; Type 2/complications/pathology
Creator
An entity primarily responsible for making the resource
Yu Bing; Alboslemy Talib; Safadi Fayez; Kim Min-Ho
Description
An account of the resource
The process of wound repair requires the coordinated participation of multiple types of cells, which are sequentially recruited during the healing process. In response to tissue injury, both macrophages and mesenchymal stem cells (MSCs) are recruited to the site of injury, where they participate in the repair process. Despite considerable understanding of the role of each cell type in the process of wound repair, the nature of the dynamic interplay between these two cell types and how this interaction influences the process of wound repair are not well understood. Here, using an in vivo model of cutaneous wound healing in mice, we provide evidence that GPNMB is functionally important in promoting the recruitment of MSCs to the site of skin injury, which in turn modulates inflammatory responses by directing the M2 polarization of macrophages in acute wound healing. Furthermore, we show that GPNMB activity is impaired in a diabetic wound environment, which is associated with impaired MSC recruitment that is reversed by the topical administration of recombinant GPNMB protein to the wounds of diabetic mice. Our study provides important insight into the crosstalk between macrophages and endogenous MSCs toward wound repair.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.jid.2017.08.034" target="_blank" rel="noreferrer noopener">10.1016/j.jid.2017.08.034</a>
2018
Administration
Alboslemy Talib
Animal
Animals
Cell Communication/*physiology
Cell Differentiation
Cells
Cultured
Cutaneous
Diabetes Mellitus
Disease Models
Eye Proteins/administration & dosage/genetics/*physiology
Humans
Inbred C57BL
Kim Min-Ho
Macrophages/*physiology
Male
Membrane Glycoproteins/administration & dosage/genetics/*physiology
Mesenchymal Stem Cells/*physiology
Mice
Recombinant Proteins/administration & dosage/genetics/metabolism
Safadi Fayez
Skin/*injuries/metabolism
The Journal of investigative dermatology
Type 2/complications/pathology
Wound Healing/*physiology
Yu Bing
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/icb.2014.60" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/icb.2014.60</a>
Pages
837–850
Issue
10
Volume
92
Dublin Core
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Title
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Members of the novel UBASH3/STS/TULA family of cellular regulators suppress
Publisher
An entity responsible for making the resource available
Immunology and cell biology
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-11
Subject
The topic of the resource
Animals; Antigen; Colitis/*immunology; Humans; Knockout; Mice; Phosphorylation; Protein Tyrosine Phosphatases/genetics/*physiology; Receptors; T-Cell/genetics/*physiology; T-Lymphocytes/*immunology; ZAP-70 Protein-Tyrosine Kinase/metabolism
Creator
An entity primarily responsible for making the resource
Newman Tiffanny N; Liverani Elisabetta; Ivanova Elitza; Russo Gian L; Carpino Nick; Ganea Doina; Safadi Fayez; Kunapuli Satya P; Tsygankov Alexander Y
Description
An account of the resource
The UBASH3/STS/TULA family consists of two members sharing substantial homology and a similar multi-domain architecture, which includes a C-terminal histidine phosphatase domain capable of dephosphorylating phosphotyrosine-containing substrates. TULA-family proteins act as downregulators of receptor-induced activation in several cell types, including T cells and platelets. Deletion of both family members in mice has been shown to result in hyperresponsiveness of T cells to T-cell receptor (TCR)/CD3 complex engagement, but little is known about the biological consequences of double knockout (dKO) and especially of either single KO (sKO). We elucidated the biological consequences of the lack of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/icb.2014.60" target="_blank" rel="noreferrer noopener">10.1038/icb.2014.60</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Antigen
Carpino Nick
Colitis/*immunology
Department of Anatomy & Neurobiology
Ganea Doina
Humans
Immunology and cell biology
Ivanova Elitza
Knockout
Kunapuli Satya P
Liverani Elisabetta
Mice
NEOMED College of Medicine
Newman Tiffanny N
Phosphorylation
Protein Tyrosine Phosphatases/genetics/*physiology
Receptors
Russo Gian L
Safadi Fayez
T-Cell/genetics/*physiology
T-Lymphocytes/*immunology
Tsygankov Alexander Y
ZAP-70 Protein-Tyrosine Kinase/metabolism