1
40
1
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
154-163
Issue
3
Volume
11
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
CEFADROXIL, CEFACLOR, CEFUROXIME - INTERSTITIAL FLUID CONCENTRATIONS DETERMINED THROUGH A SKIN WINDOW
Publisher
An entity responsible for making the resource available
Advances in Therapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-05
Subject
The topic of the resource
cefaclor; cefadroxil; cefuroxime; interstitial fluid; pharmacokinetics; Pharmacology & Pharmacy; Research & Experimental Medicine; skin window
Creator
An entity primarily responsible for making the resource
Tan J S; Salstrom S J M; File T M
Description
An account of the resource
The complex interaction between plasma and tissue concentrations of drug has significant implications for therapies that use beta-lactam antibiotics. This comparative, triple-crossover, open-label study enrolled 12 healthy adult male volunteers to determine interstitial fluid concentrations of cefadroxil, cefaclor, and cefuroxime. Each participant, by random assignment, received therapeutically equivalent (in skin and skin-structure infections) single oral doses of cefadroxil 500 mg, cefaclor 250 mg, and cefuroxime axetil 250 mg on separate occasions 1 week apart. Serum and interstitial fluid (by skin-window technique) concentrations were assayed sequentially to determine persistence and magnitude of antibiotic penetration into interstitial fluid. Statistically higher concentrations of cefadroxil (5.5 mug/mL) than of cefaclor (1.2 mug/mL) and cefuroxime (1.1 mug/mL) were documented in interstitial fluid. Cefadroxil (0.63) also demonstrated a tissue fluid:blood area under the curve ratio significantly greater than that achieved by cefaclor (0.48) and comparable to that of cefuroxime axetil (0.60). No significant adverse events occurred with any study medication. The distribution to interstitial fluids and reliable tissue penetration are fundamental principles of successful antibacterial therapy of skin and skin-structure infections. The excellent tissue and interstitial fluid penetration of cefadroxil may contribute to its high degree of efficacy when administered once daily.
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1994
Advances in Therapy
cefaclor
cefadroxil
cefuroxime
File T M
interstitial fluid
Journal Article
pharmacokinetics
Pharmacology & Pharmacy
Research & Experimental Medicine
Salstrom S J M
skin window
Tan J S