1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2013/371813</a>
Pages
371813–371813
Volume
2013
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/ beta -Catenin Signaling Pathway.
Publisher
An entity responsible for making the resource available
Evidence-based complementary and alternative medicine : eCAM
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Creator
An entity primarily responsible for making the resource
Bhatia Deepak; Thoppil Roslin J; Mandal Animesh; Samtani Karishma A; Darvesh Altaf S; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide, and chemoprevention represents a viable approach in lowering the mortality of this disease. Pomegranate fruit, an abundant source of anti-inflammatory phytochemicals, is gaining tremendous attention for its wide-spectrum health benefits. We previously reported that a characterized pomegranate emulsion (PE) prevents diethylnitrosamine (DENA)-induced rat hepatocarcinogenesis though inhibition of nuclear factor-kappaB (NF- kappa B). Since NF- kappa B concurrently induces Wnt/ beta -catenin signaling implicated in cell proliferation, cell survival, and apoptosis evasion, we examined antiproliferative, apoptosis-inducing and Wnt/ beta -catenin signaling-modulatory mechanisms of PE during DENA rat hepatocarcinogenesis. PE (1 or 10 g/kg) was administered 4 weeks before and 18 weeks following DENA exposure. There was a significant increase in hepatic proliferation (proliferating cell nuclear antigen) and alteration in cell cycle progression (cyclin D1) due to DENA treatment, and PE dose dependently reversed these effects. PE substantially induced apoptosis by upregulating proapoptotic protein Bax and downregulating antiapoptotic protein Bcl-2. PE dose dependently reduced hepatic beta -catenin and augmented glycogen synthase kinase-3 beta expression. Our study provides evidence that pomegranate phytochemicals exert chemoprevention of hepatic cancer through antiproliferative and proapoptotic mechanisms by modulating Wnt/ beta -catenin signaling. PE, thus, targets two interconnected molecular circuits (canonical NF- kappa B and Wnt/ beta -catenin pathways) to exert chemoprevention of HCC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">10.1155/2013/371813</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Bhatia Deepak
Bishayee Anupam
Darvesh Altaf S
Department of Pharmaceutical Sciences
Evidence-based complementary and alternative medicine : eCAM
Mandal Animesh
NEOMED College of Pharmacy
Samtani Karishma A
Thoppil Roslin J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1155/2013/371813</a>
Pages
1–15
Volume
2013
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Pomegranate Bioactive Constituents Suppress Cell Proliferation and Induce Apoptosis in an Experimental Model of Hepatocellular Carcinoma: Role of Wnt/β-Catenin Signaling Pathway.
Publisher
An entity responsible for making the resource available
Evidence-based Complementary & Alternative Medicine (eCAM)
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-01
Subject
The topic of the resource
Immunohistochemistry; Gene Expression; Apoptosis; Rats; Pomegranate; Post Hoc Analysis; One-Way Analysis of Variance; Structural Equation Modeling; Experimental Studies; Protocols; Carcinoma; Blotting; Western; Hepatocellular; Animal Studies; In Vivo Studies
Creator
An entity primarily responsible for making the resource
Bhatia Deepak; Thoppil Roslin J; Mandal Animesh; Samtani Karishma A; Darvesh Altaf S; Bishayee Anupam
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1155/2013/371813" target="_blank" rel="noreferrer noopener">10.1155/2013/371813</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Animal Studies
Apoptosis
Bhatia Deepak
Bishayee Anupam
Blotting
Carcinoma
Darvesh Altaf S
Department of Pharmaceutical Sciences
Evidence-based Complementary & Alternative Medicine (eCAM)
Experimental Studies
Gene Expression
Hepatocellular
Immunohistochemistry
In Vivo Studies
Mandal Animesh
NEOMED College of Pharmacy
One-Way Analysis of Variance
Pomegranate
Post Hoc Analysis
Protocols
Rats
Samtani Karishma A
STRUCTURAL equation modeling
Thoppil Roslin J
Western