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Text
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URL Address
<a href="http://doi.org/10.1097/01.brs.0000168550.65726.cb" target="_blank" rel="noreferrer noopener">http://doi.org/10.1097/01.brs.0000168550.65726.cb</a>
Pages
1491–1495
Issue
13
Volume
30
Dublin Core
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Title
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Effects of growth hormone transgene expression on vertebrae in a mouse model of osteogenesis imperfecta.
Publisher
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Spine
Date
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2005
2005-07
Subject
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Animal; Animals; Biomechanical Phenomena; Bone Density; Disease Models; Female; Gene Expression; Genetic Therapy/*methods; Heterozygote; Human Growth Hormone/*genetics; Humans; Inbred C57BL; Male; Mice; Osteogenesis Imperfecta/pathology/physiopathology/*therapy; Spine/pathology/*physiology; Tail; Transgenic
Creator
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King Donna; Chase Jeff; Havey Robert M; Voronov Leonard; Sartori Mark; McEwen Heather A; Beamer Wesley G; Patwardhan Avinash G
Description
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STUDY DESIGN: A human growth hormone transgene was bred into mice of the Cola2oim (oim) lineage. Caudal (tail) vertebrae from male and female mice at early skeletal maturity and at midlife were evaluated for physical and biomechanical properties. OBJECTIVE: To test whether constant low-level growth hormone expression within the marrow could improve structural or material properties of caudal vertebrae in oim mice. SUMMARY OF BACKGROUND DATA: A spontaneous genetic defect in a type I procollagen gene created the oim mouse model for osteogenesis imperfecta. Bones of heterozygous oim mice are biomechanically inferior to wild-type controls. Bone marrow expression of human growth hormone was demonstrated previously to enhance bone deposition and structural biomechanical properties in caudal vertebrae of transgenic mice. METHODS: Compression tests were performed individually on three caudal vertebrae (Ca4, 5, and 6) from each mouse to determine their structural biomechanical properties. Volumetric and mineral content measurements were also made. In a subset of vertebrae, the ashing measurements were confirmed and extended by peripheral quantitative tomographic scanning, which also allowed calculation of the failure stress. RESULTS: Heterozygous oim mouse vertebrae had structural and material properties inferior to the wild-type controls. Growth hormone transgene expression increased the size and mineral content of the vertebrae from mutant mice, and increased biomechanical structural values for maximum load and energy to failure. Failure stress was not improved. CONCLUSIONS: Growth hormone stimulation of size and bone mineral content of osteogenesis imperfecta mutant mouse caudal vertebrae contributed to their improved performance in axial compression. There was no evidence for improved material properties, however.
Identifier
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<a href="http://doi.org/10.1097/01.brs.0000168550.65726.cb" target="_blank" rel="noreferrer noopener">10.1097/01.brs.0000168550.65726.cb</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Animal
Animals
Beamer Wesley G
Biomechanical Phenomena
Bone Density
Chase Jeff
Department of Family & Community Medicine
Disease Models
Female
Gene Expression
Genetic Therapy/*methods
Havey Robert M
Heterozygote
Human Growth Hormone/*genetics
Humans
Inbred C57BL
King Donna
Male
McEwen Heather A
Mice
NEOMED College of Medicine
Osteogenesis Imperfecta/pathology/physiopathology/*therapy
Patwardhan Avinash G
Sartori Mark
Spine
Spine/pathology/*physiology
Tail
Transgenic
Voronov Leonard