1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2-2
Volume
178
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Locate full-text within NEOMED Library's e-journal collections
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Function of the fractalkine receptor during autoimmune inflammation
Publisher
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Journal of Immunology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-04
Subject
The topic of the resource
Immunology
Creator
An entity primarily responsible for making the resource
Cardona A E; Sasse M E; Cardona S M; Mazutani M; Hamann I
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2007
Cardona A E
Cardona S M
Hamann I
Immunology
Journal Article or Conference Abstract Publication
Journal of Immunology
Mazutani M
Sasse M E
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1182/blood-2007-10-118497" target="_blank" rel="noreferrer noopener">http://doi.org/10.1182/blood-2007-10-118497</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
256-263
Issue
2
Volume
112
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues
Publisher
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Blood
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-07
Subject
The topic of the resource
in-vitro; central-nervous-system; Hematology; blood-brain-barrier; ccx-ckr; cutting edge; d6; dendritic cell; experimental autoimmune encephalomyelitis; immune-response; sjogrens-syndrome
Creator
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Cardona A E; Sasse M E; Liu L P; Cardona S M; Mizutani M; Savarin C; Hu T; Ransohoff R M
Description
An account of the resource
In vitro studies have implicated chemokine receptors in consumption and clearance of specific ligands. We studied the role that various signaling chemokine receptors play during ligand homeostasis in vivo. We examined the levels of ligands in serum and CNS tissue in mice lacking chemokine receptors. Compared with receptor-sufficient controls, Cx3cr1(-/-) mice exhibited augmented levels of CX3CL1 both in serum and brain, and circulating levels of CXCL1 and CXCL2 were increased in Cxcr2(-/-) mice. CCR2-deficient mice showed significantly increased amounts of circulating CCL2 compared with wild-type mice. Cxcr3(-/-) mice revealed increased levels of circulating and brain CXCL10 after experimental autoimmune encephalomyelitis (EAE) induction. CCR2-deficient peripheral blood and resident peritoneal cells exhibited reduced binding capacity and biologic responses to the CCR1 ligand CCL3, suggesting that elevated levels of CCR2 ligands had down-regulated CCR1. The results indicate that signaling chemokine receptors clear chemokines from circulation and tissues. These homeostatic functions of signaling chemokine receptors need to be integrated into safety and efficacy calculations when considering therapeutic receptor blockade.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1182/blood-2007-10-118497" target="_blank" rel="noreferrer noopener">10.1182/blood-2007-10-118497</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2008
Blood
blood-brain-barrier
Cardona A E
Cardona S M
ccx-ckr
central-nervous-system
cutting edge
d6
dendritic cell
experimental autoimmune encephalomyelitis
Hematology
Hu T
immune-response
in-vitro
Journal Article or Conference Abstract Publication
Liu L P
Mizutani M
Ransohoff R M
Sasse M E
Savarin C
sjogrens-syndrome