1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address n/a Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 348-354 Issue 5 Volume 78 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Evaluation Of The Efficacy And Safety Of Clobetasol Propionate Spray 'in The Treatment Of Plaque-type Psoriasis Publisher An entity responsible for making the resource available Cutis Date A point or period of time associated with an event in the lifecycle of the resource 2006 2006-11 Subject The topic of the resource 0.05-percent; blind; Dermatology; foam; quality-of-life Creator An entity primarily responsible for making the resource Jarratt M T; Clark S D; Savin R C; Swinyer L J; Safley C F; Brodell R T; Yu K Description An account of the resource Treatment of the inflammatory component of plaque psoriasis is an important part of psoriasis management. A new and unique spray formulation of clobetasol propionate 0.05% may provide advantages over the currently available formulations through easy application to hard-to-reach areas and the ability to deliver a fixed dose of corticosteroid per spray. The purpose of this study was to evaluate the efficacy and safety of clobetasol propionate spray 0.05% in the treatment of moderate to severe plaque-type psoriasis. This study was conducted as a multicenter, randomized, double-blinded, vehicle-controlled, parallel-group, comparative study in subjects with plaque psoriasis. Subjects were randomized to receive either clobetasol propionate spray 0.05% (n=60) or vehicle spray (n=60) twice daily for 4 weeks, followed by a 4-week treatment-free follow-up period. Efficacy evaluations at all visits included assessment of scaling, erythema, plaque elevation, pruritus, and overall disease severity. Success rates for each of the signs and symptoms evaluated, as well as for the overall disease severity assessment, were significantly in favor of clobetasol propionate (P <=.001). The additional 2 weeks of treatment from weeks 2 to 4 increased the number of cleared subjects from 2% to 25%; treatment success was still in favor of clobetasol propionate (P <.001) at week 8 (4 weeks posttreatment). No treatment-related serious adverse events occurred during the course of the study. Mild application site burning/stinging was the most common treatment-related adverse event, with similar frequency and severity for both active and vehicle groups, There were no reports of skin atrophy, telangiectasia, folliculitis, orhypothalamus-pituitary-adrenal axis suppression. Overall, clobetasol propionate spray 0.05% administered twice daily for 4 weeks was effective and safe in reducing scaling, erythema, plaque elevation, and overall disease severity and demonstrates durable clinical response up to 4 weeks after treatment end. Identifier An unambiguous reference to the resource within a given context n/a Format The file format, physical medium, or dimensions of the resource Journal Article or Conference Abstract Publication 0.05-percent 2006 blind Brodell R T Clark S D Cutis Dermatology FOAM Jarratt M T Journal Article or Conference Abstract Publication quality-of-life Safley C F Savin R C Swinyer L J Yu K