Browse Items · NEOMED Bibliography Database

Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats.

Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place…

Tags: 1992, Animals, Avoidance Learning/*drug effects, Conditioning, Dose-Response Relationship, Drug, Ethanol/*pharmacology, Krimmer E C, Motor Activity/drug effects, Operant/drug effects, Psychopharmacology, Rats, Schechter M D, Sleep/drug effects, Species Specificity

The discriminative properties of the D1 dopamine agonist dihydrexidine in the rat.

The objective of this study was to train rats to discriminate the interoceptive stimuli produced by a selective dopamine D1 agonist. Fourteen male Sprague-Dawley rats acquired the discrimination of the fully effective, high potency, D1 agonist…

Tags: 1995, Amphetamine/pharmacology, Animals, Apomorphine/pharmacology, Benzazepines/pharmacology, Cocaine/pharmacology, Discrimination (Psychology), Dopamine Agonists/pharmacology, Dopamine D1/*agonists, Dose-Response Relationship, Drug, Male, Phenanthridines/*pharmacology, Psychopharmacology, Rats, Receptors, Schechter M D, Sprague-Dawley

Comparison of the behavioral effects of ibogaine from three sources: mediation of discriminative activity.

Ibogaine is an alkaloid employed for its hallucinatory properties in West Central Africa which has been the subject of alleged efficacy as an aid in the interruption and treatment of chemical dependency. The major sources of the Schedule I agent are:…

Tags: *Discrimination (Psychology), 1993, Animal/*drug effects, Animals, Behavior, Dose-Response Relationship, Drug, European journal of pharmacology, Gordon T L, Ibogaine/*pharmacology, Male, Rats, Schechter M D, Serotonin Receptor Agonists/pharmacology, Sprague-Dawley

Conditioned place preference produced by the psychostimulant cathinone.

Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced…

Tags: 1993, Alkaloids/administration & dosage/*pharmacology, Animals, Central Nervous System Stimulants/administration & dosage/*pharmacology, Choice Behavior/drug effects, Conditioning (Psychology)/drug effects, Dose-Response Relationship, Drug, European journal of pharmacology, Habituation, Male, Meehan S M, Motor Activity/*drug effects, Psychophysiologic, Rats, Schechter M D, Sprague-Dawley

Conditioned place aversion produced by dopamine release inhibition.

CGS 10746B, a dopamine release inhibitor with properties similar to the atypical antipsychotic clozapine, was assessed as to its behavioral properties using spontaneous locomotor activity and the conditioned place preference test. Rats conditioned…

Genetic selection for nicotine activity in mice correlates with conditioned place preference.

Genetically heterogenous stock (HS) mice are being used to develop lines which have differential locomotor response to subcutaneously administered (0.75 mg/kg) nicotine. These groups of nicotine-depressed, nicotine-activated or randomly bred control…

Tags: *Conditioning, 1995, Analysis of Variance, Animals, European journal of pharmacology, Female, Inbred Strains, Male, Meehan S M, Mice, Movement/*drug effects, Nicotine/*pharmacology, Operant, Schechter J B, Schechter M D

Blockade of cocaine-induced conditioned place preference: relevance to cocaine abuse therapeutics.

Conditioned place preference/aversion testing is a behavioral method believed capable of measuring the affective (positive, neutral or negative) properties of psychoactive drugs. Cocaine injections in rats reliably produces a positive place…

Tags: 1995, Animals, Calcagnetti D J, Calcium Channel Blockers/pharmacology/therapeutic use, Cocaine/*antagonists & inhibitors, Conditioning (Psychology)/*drug effects, Humans, Keck B J, Life sciences, Narcotic Antagonists/pharmacology, Quatrella L A, Schechter M D, Serotonin Antagonists/pharmacology, Substance-Related Disorders/*drug therapy

Discriminative effects of cocaethylene in rats trained to discriminate cocaine or ethanol.

Two groups of rats were trained to discriminate between the stimulus properties of either intraperitoneally administered 10.0 mg/kg cocaine or 60 mg/kg ethanol and its vehicle in a two-lever operant chamber. Once trained, both groups exhibited a…

Tags: 1994, Animals, Cocaine/*analogs & derivatives/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*pharmacology, Inbred Strains, Life sciences, Male, Rats, Schechter M D

Isradipine produces neither a conditioned place preference nor aversion.

Isradipine (ISR) has been reported to block cocaine-induced conditioned place preference. Using this procedure, the pairing of this L-type calcium blocker, at doses of 2.5, 5.0 and 10 mg/kg, with a preferred (cue-distinct) environment was…

Tags: 1994, Animals, Calcagnetti D J, Cocaine/*pharmacology, Conditioning, Isradipine/administration & dosage/*pharmacology, Life sciences, Male, Operant/*drug effects, Rats, Schechter M D, Sprague-Dawley

Place conditioning reveals the rewarding aspect of social interaction in juvenile rats.

Rewards, as diverse as food, sweetened solutions, copulation, electrical brain stimulation, and drugs abused by humans, have been shown to condition place preferences in rats. Juvenile rats will readily learn to traverse a T-maze for the opportunity…

Tags: *Conditioning, *Motivation, *Social Behavior, *Social Environment, *Social Isolation, 1992, Animals, Calcagnetti D J, Classical/drug effects, Female, Inbred Strains, Male, Motor Activity/drug effects, Physiology & behavior, Play and Playthings, Rats, Schechter M D, Scopolamine/pharmacology, Social Dominance

Olfactory bulbectomy disrupts the expression of cocaine-induced conditioned place preference.

The role of the olfactory sense in the expression of cocaine-induced conditioned place preference (CPP) was examined in adult male rats (n = 35) of the N/Nih strain. Consistent with the scientific literature, rats were observed to significantly (p…

Lack of neuroleptic-like activity of l-fenfluramine.

Rats were trained to differentiate between the dopaminergically mediated discriminative stimuli produced by intraperitoneal administration of 4.8 mg/kg cathine and its vehicle. Once trained, three doses of l-fenfluramine (1.0, 2.0 and 2.5 mg/kg) were…

Tags: 1991, Animals, Antipsychotic Agents/*pharmacology, Cues, Discrimination (Psychology)/drug effects, Dopamine Agents/pharmacology, Dopamine Antagonists, Fenfluramine/*pharmacology, Inbred Strains, Male, Pharmacology, biochemistry, and behavior, Phenylpropanolamine/pharmacology, Rats, Schechter M D

Conditioned place aversion following the central administration of a novel dopamine release inhibitor CGS 10746B.

Numerous drugs of abuse that elevate brain extracellular dopamine concentrations by either increasing the firing rate of dopaminergic neurons or producing dopamine release have been shown to reliably condition a preference for place. If dopamine…

Tags: 1991, Animals, Antipsychotic Agents/administration & dosage/*pharmacology, Avoidance Learning/*drug effects, Calcagnetti D J, Dopamine/*metabolism, Inbred Strains, Injections, Intraventricular, Male, Motor Activity/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/administration & dosage/*pharmacology

Direct microinjection of cathinone into the rat brain produces discriminative stimuli.

Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower…

Effect of altering dopamine or serotonin neurotransmitters upon cathinone discrimination.

Rats were trained to discriminate between the stimulus properties of 0.8 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-related decrease in discriminative performance when tested with…

Further evidence for the mechanisms that may mediate nicotine discrimination.

Rats were trained to discriminate the interoceptive stimuli produced by subcutaneously administered 0.4 mg/kg nicotine in a two-lever, food-motivated, operant task. Once criterion performance was attained, dose-response experiments indicated an ED50…

Tags: 1992, Animals, Calcium Channel Blockers/pharmacology, Dihydropyridines/pharmacology, Discrimination Learning, Dopamine/*metabolism, Dose-Response Relationship, Drug, Inbred Strains, Indoles/pharmacology, Isradipine, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Thiazepines/pharmacology, Tropisetron

Rats bred for differences in preference to cocaine: other behavioral measurements.

Cocaine has repeatedly been shown to produce conditioned place preference (CPP) in the rat. The present study employed the heterogenous N/Nih rat stock to produce a selectively bred rat line determined by individual place preference to a conditioning…

Tags: 1992, Animal/*drug effects, Animals, Behavior, Choice Behavior/*drug effects, Cocaine/*pharmacology, Dose-Response Relationship, Drug, Female, Inbred Strains, Male, Motor Activity/drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Species Specificity, Sprague-Dawley

Psychostimulant-induced activity is attenuated by two putative dopamine release inhibitors.

Centrally administered amphetamine (AMPH), cathinone, (CATH), or cocaine (COC) have each been shown to produce elevated activity in rats and this effect is dose responsive. The question remains whether these psychostimulants share a common mechanism…

Evidence for noradrenergic involvement in mediating the FG 7142 discriminative stimulus.

Rats were trained to discriminate the stimulus properties of the benzodiazepine receptor partial inverse agonist beta-carboline-3-carboxylate acid methyl amide (FG 7142) (5.0 mg/kg) or the alpha 2-adrenergic receptor antagonist 17…

Differential effects of nicotine but not cathinone on motor activity of P and NP rats.

The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in…

Tags: 1993, Alcohol Drinking/*psychology, Alkaloids/*pharmacology, Animals, Dextroamphetamine/pharmacology, Discrimination (Psychology)/drug effects, Genotype, Gordon T L, Male, Meehan S M, Motor Activity/*drug effects, Nicotine/*pharmacology, Pharmacology, biochemistry, and behavior, Psychotropic Drugs/*pharmacology, Rats, Schechter M D

Cocaine discrimination is attenuated by isradipine and CGS 10746B.

The discriminative stimulus properties of cocaine are thought to be mediated by dopaminergic mechanisms that may be modulated by calcium ion influx and/or interact with 5-hydroxytryptamine3 (5-HT3) receptors. To test these possibilities, rats were…

P and NP rats respond differently to the discriminative stimulus effects of nicotine.

Rats selectively bred for ethanol preference, that is, alcohol-preferring (P) and -nonpreferring (NP) rats, were trained to discriminate the interoceptive stimuli produced by IP-administered 1,000 mg/kg ethanol (10% v/v) in a two-lever,…

Tags: 1993, Alcoholism/genetics, Animals, Behavioral, Discrimination Learning/*drug effects/physiology, Drug Tolerance/genetics, Ethanol/administration & dosage/*pharmacology, Genetics, Gordon T L, Male, Meehan S M, Nicotine/administration & dosage/*pharmacology, Pharmacology, biochemistry, and behavior, Rats, Schechter M D

Discriminative stimulus properties of isradipine: effect of other calcium channel blockers.

This study constitutes the first report of a calcium channel blocker used as a drug capable of controlling differential responding in a drug-discrimination paradigm. Male Sprague-Dawley rats were trained to discriminate between intraperitoneally…

Tags: 1995, Animals, Calcium Channel Blockers/*pharmacology, Conditioning, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Generalization, Isradipine/*pharmacology, Male, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley, Stimulus/*drug effects

Cocaethylene produces discriminative stimulus properties in the rat: effect of cocaine and ethanol coadministration.

Experimentally naive Sprague-Dawley male rats were trained to discriminate the interoceptive stimulus cues produced by either 10.0 mg/kg cocaine or 10.0 mg/kg cocaethylene from their saline vehicles. Although it required more sessions to train the…

Tags: 1995, Animals, Cocaine/*analogs & derivatives/pharmacokinetics/*pharmacology, Discrimination (Psychology)/*drug effects, Dose-Response Relationship, Drug, Ethanol/pharmacokinetics/*pharmacology, Male, Pharmacology, biochemistry, and behavior, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Serotonergic mediation of cocaine seizures in mice.

We used genetically heterogeneous HS mice to investigate the effects of drugs that alter brain concentrations of serotonin on cocaine-induced convulsions and lethality. The racemer of fenfluramine, which increases synaptic serotonin, was…

Role of dopamine D1 receptors in cocaine lethality.

One group of heterogeneously bred HS mice was assigned to test coadministration of the selective D1 antagonist SCH 23390 with a dose of cocaine (95 mg/kg) that was observed to produce 80% lethality, whereas a second group was tested by cotreatment…

Tags: 1995, Animals, Benzazepines/pharmacology, Cocaine/*toxicity, Dopamine Agonists/pharmacology, Dopamine D1/agonists/antagonists & inhibitors/*drug effects, Female, Inbred Strains, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Phenanthridines/pharmacology, Receptors, Schechter M D, Sex Characteristics

Cocaethylene produces conditioned place preference in rats.

The ability of cocaethylene to produce either a conditioned place preference or a conditioned place aversion was tested in rats. Twelve male rats were administered 10 mg/kg cocaethylene and confined to their nonpreferred side of the conditioned place…

Tags: 1995, Animals, Avoidance Learning/drug effects, Cocaine/*analogs & derivatives/pharmacology, Conditioning, Discrimination (Psychology)/drug effects, Male, Motor Activity/*drug effects, Operant/*drug effects, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Sprague-Dawley

The lethal effects of ethanol and cocaine and their combination in mice: implications for cocaethylene formation.

The HS line of mice was used to determine the LD50 values for cocaine and ethanol, as well as for cocaethylene, the enzymatic product of their coadministration. The LD50 of cocaethylene was found to be significantly lower than that of cocaine, and…

Tags: 1995, Animals, Central Nervous System Depressants/*toxicity, Cocaine/*analogs & derivatives/metabolism/toxicity, Dopamine Uptake Inhibitors/*toxicity, Dose-Response Relationship, Drug, Drug Interactions, Ethanol/*toxicity, Female, Lethal Dose 50, Male, Meehan S M, Mice, Pharmacology, biochemistry, and behavior, Schechter M D, Sex Characteristics

Cocaethylene-induced kindling of seizure effects: cross-specificity with cocaine.

Sensitization and cross-sensitization to the seizurogenic effects of cocaine and cocaethylene were examined in the HS strain of mice. Animals were administered IP injections of either 48 mg/kg cocaine or 32 mg/kg cocaethylene once per day for 4 days.…

Tags: 1996, Animals, Cocaine/*analogs & derivatives/pharmacology, Convulsants/*pharmacology, Dopamine Uptake Inhibitors/*pharmacology, Drug Interactions, Epilepsy, Female, Inbred Strains, Kindling, Male, Meehan S M, Mice, Neurologic/*drug effects, Pharmacology, biochemistry, and behavior, Schechter M D, Seizures/*chemically induced, Status Epilepticus/chemically induced, Tonic-Clonic/chemically induced

Discriminative stimulus properties of CGS 10746B: similarity to dopamine D1 receptor antagonists.

CGS 10746B is an imidazole-derivative related to the atypical antipsychotic clozapine which produces a decrease in dopamine release without altering dopamine metabolism or occupying D2 receptors. Rats were trained on an appetitively-motivated,…

Reducing the time needed to conduct conditioned place preference testing.

The objective of the present experiment was to demonstrate whether four days of twice-a-day conditioned place conditioning produces a preference that is equivalent to that produced by using eight days of once-a-day training. Two doses of the…

Tags: 1992, Alkaloids/pharmacology, Animals, Calcagnetti D J, Choice Behavior/*drug effects, Conditioning, Experimental/instrumentation/methods, Inbred Strains, Male, Motor Activity/drug effects, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Psychology, Psychotropic Drugs/pharmacology, Rats, Schechter M D

Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.

1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats…

Differential training sequence effect upon psychostimulant discrimination.

1. Previous studies indicate that rats trained to discriminate either cathinone or cathine from its vehicle have a diminished discriminative performance when tested 24 hours after a drug administration when compared to tests conducted after a vehicle…

Tags: 1993, Alkaloids/pharmacology, Animals, Appetite Depressants/pharmacology, Central Nervous System Stimulants/*pharmacology, Discrimination Learning/*drug effects, Dose-Response Relationship, Drug, Food, Male, Phenylpropanolamine/pharmacology, Progress in neuro-psychopharmacology & biological psychiatry, Psychotropic Drugs/pharmacology, Rats, Reinforcement Schedule, Schechter M D, Sprague-Dawley

Dopaminergic mediation of the stimulant generalization of nicotine.

1. Experiments were conducted to investigate if the psychostimulant cathinone, like d-amphetamine, would produce generalization of the discriminative stimulus effects of nicotine. 2. Rats were trained to discriminate either 0.8 mg/kg cathinone from…

Conditioned place preference/aversion to fenfluramine in fawn hooded and sprague-Dawley rats.

The Fawn Hooded (FH) rat strain possesses a genetic platelet storage pool deficiency which leads to an impaired capacity for platelets to store and release serotonin. While the relationship between this deficit and possible alterations in brain…

Tags: 1994, Animals, Avoidance Learning/*drug effects, Blood Platelets/metabolism, Brain Chemistry/genetics, Fenfluramine/*pharmacology, Habituation, Inbred Strains, Meehan S M, Platelet Storage Pool Deficiency/physiopathology, Progress in neuro-psychopharmacology & biological psychiatry, Psychophysiologic/drug effects, Rats, Schechter M D, Serotonin/metabolism/physiology, Species Specificity, Sprague-Dawley

Nicotine place preference using the biased method of conditioning.

1. The objective of the experimentation was to determine whether nicotine (NIC, 0.8 mg/kg subcutaneously administered) would produce a conditioned place preference (CPP) in rats confined for thirty min to their less-preferred side in a three…

Tags: 1994, Animals, Calcagnetti D J, Conditioning, Cues, Injections, Male, Motor Activity/drug effects, Nicotine/*pharmacology, Operant/*drug effects, Progress in neuro-psychopharmacology & biological psychiatry, Rats, Schechter M D, Sprague-Dawley, Subcutaneous

Scopolamine-physostigmine combination does not substitute for nicotine.

1. Male Sprague-Dawley rats were trained to discriminate 0.4 mg/kg nicotine subcutaneously administered from its saline vehicle in a food-motivated operant discrimination task. Once trained, the discriminative performance was observed to be…

Premorbid behaviors produced by cocaine, ethanol and cocaethylene in the mouse.

1. The premorbid behaviors produced by the administration of cocaine, ethanol, their combination, as well as a metabolite produced by their co-administration, viz. cocaethylene, were defined, determined and quantified in the HS strain of mice. 2. The…

Tags: 1995, Animal/*drug effects, Animals, Behavior, Cocaine/*analogs & derivatives/*toxicity, Dose-Response Relationship, Drug, Ethanol/*toxicity, Female, General pharmacology, Lethal Dose 50, Male, Meehan S M, Mice, Schechter M D

Increases in the locomotor activity of rats after intracerebral administration of cathinone.

There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine…

Tags: 1992, Alkaloids/administration & dosage/*pharmacology, Animals, Brain research bulletin, Calcagnetti D J, Cerebral Ventricles/drug effects/*physiology, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Motor Activity/*drug effects, Nucleus Accumbens/drug effects/*physiology, Psychotropic Drugs/administration & dosage/*pharmacology, Rats, Schechter M D, Sprague-Dawley, Stereotaxic Techniques, Substantia Nigra/drug effects/*physiology

Attenuation of drinking sweetened water following calcium channel blockade.

Recent reports cite results that both cocaine-induced conditioned place preference and activity stimulation are attenuated by pretreatment with the calcium channel blocker isradipine (ISR) in rats. By blocking voltage-dependent

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