Do Attitudes Matter? Evaluating the Influence of Training in CBT-p-Informed Strategies on Attitudes About Working with People Who Experience Psychosis.
alliance; Attitudes; beliefs; CBT-p informed skills; Cognitive behavioral therapy for psychosis; cognitive-behavioral therapy; dangerousness; illness; mental-health professionals; outcomes; perceptions; Recovery; schizophrenia; schizophrenia; staff attitudes; Stigma
Attitudes of mental health providers are an important consideration in training and delivering evidence-based practices. Treatment approaches for individuals who experience schizophrenia consistently endorse the importance of a recovery perspective. At the same time, a review of the literature suggests that the attitudes of many providers and many policies of community health care settings serving individuals who experience schizophrenia, may not align with the recovery perspective. This brief report provides a summary of the program evaluation outcomes of a wide range of mental health providers who participated in a 2-day intensive training to learn strategies informed by Cognitive Behavioral Therapy for Psychosis (CBT-p). This intensive training emphasizes engagement strategies and person-centered approaches inherent in the recovery perspective. Consistent with the aims of the training, participants' attitudes about working with people who experience psychosis appeared to be positively influenced by training.
Sivec Harry J; Kreider Valerie A L; Buzzelli Christopher; Hrouda Debra R; Hricovec Megan M
Community mental health journal
2020
2020-03-28
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1007/s10597-020-00611-w" target="_blank" rel="noreferrer noopener">10.1007/s10597-020-00611-w</a>
Efficacy of Instagram in Promoting Psychoeducation in the Chinese-Speaking Population.
Chinese; first-episode psychosis; Instagram; schizophrenia; YouTube
Purpose: To evaluate the efficacy of the use of Instagram in disseminating information regarding first-episode psychosis and schizophrenia. Methods: Facebook and Instagram advertisements linked to an external YouTube video detailing first-time psychosis were initiated for 48 h. Metrics regarding the number of unique individuals reached and number of engagements were collected. Descriptive statistics were used to analyze the data. Results: Facebook made 85 impressions (32.82%) and Instagram made 174 impressions (67.18%). Facebook had 24 engagements, whereas Instagram had 42. Conclusion: Instagram is noninferior to Facebook in disseminating psychoeducational material to the Chinese-speaking population.
Lam Nikki H T; Woo Benjamin K P
Health equity
2020
1905-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
journalArticle
<a href="http://doi.org/10.1089/heq.2019.0078" target="_blank" rel="noreferrer noopener">10.1089/heq.2019.0078</a>
Psychotic disorders in late life: a narrative review
schizophrenia; geriatric; elderly; schizoaffective disorder; psychotic disorders; delusional disorder; late life; late-onset schizophrenia; very late-onset schizophrenia-like psychosis
Psychotic disorders are not uncommon in late life. These disorders often have varied etiologies, different clinical presentations, and are associated with significant morbidity and mortality among the older adult population. Psychotic disorders in late life develop due to the complex interaction between various biological, psychological, social, and environmental factors. Given the significant morbidity and mortality associated with psychotic disorders in late life, a comprehensive work-up should be conducted when they are encountered. The assessment should not only identify the potential etiologies for the psychotic disorders, but also recognize factors that predicts possible outcomes for these disorders. Treatment approaches for psychotic disorders in late life should include a combination of nonpharmacological management strategies with the judicious use of psychotropic medications. When antipsychotic medications are necessary, they should be used cautiously with the goal of optimizing outcomes with regular monitoring of their efficacy and adverse effects.
Tampi Rajesh R; Young Juan; Hoq Rakin; Resnick Kyle; Tampi Deena J
Therapeutic Advances In Psychopharmacology
2019
1905-07
Journal Article
<a href="http://doi.org/10.1177/2045125319882798" target="_blank" rel="noreferrer noopener">10.1177/2045125319882798</a>
PMID: 31662846 PMCID: PMC6796200
Brain Macrostructural And Microstructural Abnormalities In Cocaine Dependence
abstinent; abuse; addiction; alcohol; brain; chronic cerebral hypoperfusion; cocaine; dependence; diffusion tensor imaging (DTI); drug-abuse; gerbil brain; magnetic resonance imaging (MRI); prefrontal cortex; Psychiatry; schizophrenia; Substance Abuse; users; white-matter integrity
Rationale: Two previous studies have utilized diffusion tensor imaging (DTI) to examine microstructural integrity in cocaine abuse and found 41 evidence of brain abnormalities in white matter. Objective: Using anatomical magnetic resonance imaging (MRI), DTI, and clinical evaluation, the macrostructural and microstructural correlates of cocaine abuse were investigated. Methods: Twenty-one men and women (mean age 42.5 and mean 18.9 years of cocaine use) and 21 age/gender-matched controls were included. Fractional anisotropy (FA) was measured in frontal white matter ROIs. Gray and white matter volumes in superior and inferior frontal regions were compared. Results: DTI data revealed that cocaine users had lower FA than controls, specifically in inferior frontal white matter. FA differences were not seen in other areas. Significant volumetric differences were not seen, but both gray and white matter inferior frontal volumes trended toward smaller in the cocaine group. The data suggested that duration of use was associated with decreased gray and white matter volumes. FA and gray matter volume were correlated in cocaine users. Conclusions: Both macrostructural and microstructural abnormalities were seen in a group of cocaine abusers. Length of cocaine use was associated with severity of the brain abnormalities. Future studies of white matter tissue integrity are warranted including examination of the relationship between DTI measures and traditional volumetric measures. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Lim K O; Wozniak J R; Mueller B A; Franc D T; Specker S M; Rodriguez C P; Silverman A B; Rotrosen J P
Drug and Alcohol Dependence
2008
2008-01
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.drugalcdep.2007.07.019" target="_blank" rel="noreferrer noopener">10.1016/j.drugalcdep.2007.07.019</a>
Approaching A Consensus Cognitive Battery For Clinical Trials In Schizophrenia: The Nimh-matrics Conference To Select Cognitive Domains And Test Criteria
cognition; cognitive assessment; cognitive enhancement; impairment; memory; neural basis; neurocognition; neurocognitive deficits; neuroleptic-naive; neuropsychological function; Neurosciences & Neurology; performance; Psychiatry; psychopharmacology; risperidone; schizophrenia; siblings; thought-disorder
To stimulate the development of new drugs for the cognitive deficits of schizophrenia, the National Institute of Mental Health (NIMH) establisbed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative. This article presents an overview of decisions from the first MATRICS consensus conference . The goals of the meeting were to 1) the cognitive domains that should be represented in a consensus cognitive battery and 2) prioritize key criteria, for selection of tests for the battery. Seven cognitive domains were selected based on a review of the literatum and input from experts: working memory, attention/vigilance, verbal learning and memory, visual learning and memory. Reasoning and problem solving, speed of processing, and social cognition. Based on discussions at this meeting, five criteria were considered essential for test selection: good test-retest reliability high utility as a repeated measure, relationship to functional outcome, potential response to pharmacologic agents, and practicality/tolerability. The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizopbrenia.
Green M F; Nuechterlein K H; Gold J M; Barch D M; Cohen J; Essock S; Fenton W S; Frese F; Goldberg T E; Heaton R K; Keefe R S E; Kern R S; Kraemer H; Stover E; Weinberger D R; Zalcman S; Marder S R
Biological Psychiatry
2004
2004-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.biopsych.2004.06.023" target="_blank" rel="noreferrer noopener">10.1016/j.biopsych.2004.06.023</a>
On Consumer Advocacy And The Diagnosis Of Mental Disorders
advocacy; consumers; diagnosis; families; mental disorders; phenomenology; Psychology; recovery; schizophrenia
Frese F J; Myrick K J
Professional Psychology-Research and Practice
2010
2010-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1037/a0021527" target="_blank" rel="noreferrer noopener">10.1037/a0021527</a>
Wayne Fenton and recovery
schizophrenia; Psychiatry; recovery serious mental illness
Bellack A S; Frese F J
Schizophrenia Bulletin
2007
2007-09
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1093/schbul/sbm067" target="_blank" rel="noreferrer noopener">10.1093/schbul/sbm067</a>
Epidemiology of trauma: Childhood adversities, neighborhood problems, discrimination, chronic strains, life events, and daily hassles among people with a severe mental illness
1st-episode psychosis; adults; Childhood trauma; community; Health; national comorbidity survey; posttraumatic-stress-disorder; prevalence; Psychiatry; quality-of-life; schizophrenia; Serious mental illness; stress; symptoms; world-trade-center
Trauma during childhood and adolescence is a common event among people with a serious psychological disorder. Few studies assess a wide range of stressors for this population. This is surprising given that these stressful events are implicated in poorer outcomes related to course and treatment of mental health problems. This study of 214 people with serious mental illness examines the prevalence of childhood traumas, perceived neighborhood problems, discrimination, chronic strains, negative life events, and daily hassles. We use regression analyses to determine if these stressors are associated with quality of life. Results show that 95% of the sample report at least one childhood adversity. Perceived neighborhood problems, experiences of discrimination, chronic strains, life events, and daily hassles were also common. Examining the relationship between demographic factors and stressors suggests that older respondents, Whites, those who have never been married, and people diagnosed with Schizophrenia reported fewer stressors compared to those who are older, non-White, ever married, or suffering from other types of mental health problems. Finally, three of the six types of stressors were related to lower quality of life and depression. We discuss the implications of these findings for the treatment of severe psychological problems. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
Adams R E; Ritter C; Bonfine N
Psychiatry Research
2015
2015-12
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1016/j.psychres.2015.10.012" target="_blank" rel="noreferrer noopener">10.1016/j.psychres.2015.10.012</a>
Interventions That Target Criminogenic Needs for Justice-Involved Persons With Serious Mental Illnesses: A Targeted Service Delivery Approach
assertive community treatment; behavioral programs; criminal thinking styles; criminogenic needs; Criminology & Penology; disordered; health treatment; mental illness; offenders; prevalence; prison-inmates; Psychology; recidivism; Rehabilitation; schizophrenia; violent recidivism
This research describes the development of a targeted service delivery approach that tailors the delivery of interventions that target criminogenic needs to the specific learning and treatment needs of justice-involved people with serious mental illnesses (SMI). This targeted service delivery approach includes five service delivery strategies: repetition and summarizing, amplification, coaching, low-demand practice, and maximizing participation. Examples of how to apply each strategy in session are provided, as well as recommendations on when to use each strategy during the delivery of interventions that target criminogenic needs. This targeted service delivery approach makes an important contribution to the development of interventions for justice-involved people with SMI by increasing the chances that people with SMI can participate fully in and benefit from these interventions that target criminogenic needs. These developments come at a critical time in the field as the next generation of services for justice-involved people with SMI are being developed.
Wilson A B; Farkas K; Bonfine N; Duda-Banwar J
International Journal of Offender Therapy and Comparative Criminology
2018
2018-10
Journal Article
<a href="http://doi.org/10.1177/0306624x18759242" target="_blank" rel="noreferrer noopener">10.1177/0306624x18759242</a>
The Recovery Process Utilizing Erikson's Stages of Human Development
Counseling; Environmental & Occupational; Erikson; Health; Health; Health Care Sciences & Services; model; perspectives; Psychiatric rehabilitation; Psychiatry; Psychodevelopment; Public; recovery; schizophrenia
Of current interest to the field are clinical frameworks that foster recovery. The authors offer a psycho-developmental model that parallels Erik Erikson's theory of human development, and theorize that the process of psychiatric recovery involves a psychic reworking of these fundamental steps. Understanding recovery in this context allows the client and the practitioner of psychiatric rehabilitation to design and implement a coherent treatment strategy.
Vogel-Scibilia S E; McNulty K C; Baxter B; Miller S; Dine M; Frese F J
Community Mental Health Journal
2009
2009-12
Journal Article
<a href="http://doi.org/10.1007/s10597-009-9189-4" target="_blank" rel="noreferrer noopener">10.1007/s10597-009-9189-4</a>
Multifunctional drugs with different CNS targets for neuropsychiatric disorders
alzheimers-disease; alzheimers-disease; amyotrophic lateral sclerosis; Biochemistry & Molecular Biology; depressive illness; designed multiple ligands; hetero-cage compounds; iron chelator; Lewy body disease; monoamine oxidase inhibitor; mptp-induced neurotoxicity; neurodegenerative diseases; Neurosciences & Neurology; nicotinic acetylcholine-receptors; nonsteroidal antiinflammatory drugs; parkinsons-disease; parkinsons-disease; schizophrenia
The multiple disease etiologies that lead to neuropsychiatric disorders, such as Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, Huntington disease, schizophrenia, depressive illness and stroke, offer significant challenges to drug discovery efforts aimed at preventing or even reversing the progression of these disorders. Transcriptomic tools and proteomic profiling have clearly indicated that such diseases are multifactorial in origin. Further, they are thought to be initiated by a cascade of molecular events that involve several neurotransmitter systems. In response to this complexity, a new paradigm has recently emerged that challenges the widely held assumption that 'silver bullet' agents are superior to 'dirty drugs' in therapeutic approaches aimed at the prevention or treatment of neuropsychiatric diseases. A similar pattern of drug development has occurred in strategies for the treatment of cancer, AIDS and cardiovascular diseases. In this review, we offer an overview of therapeutic strategies and novel investigative drugs discovered or developed in our own and other laboratories, that address multiple CNS etiological targets associated with an array of neuropsychiatric disorders.
Van der Schyf C J; Geldenhuys W J; Youdim M B H
Journal of Neurochemistry
2006
2006-11
Journal Article
<a href="http://doi.org/10.1111/j.1471-4159.2006.04141.x" target="_blank" rel="noreferrer noopener">10.1111/j.1471-4159.2006.04141.x</a>
High-Yield Cognitive Behavioral Techniques for Psychosis Delivered by Case Managers to Their Clients With Persistent Psychotic Symptoms An Exploratory Trial
Case managers; CBT-p; HYCBt-p; intervention; mental-health nurses; Neurosciences & Neurology; Psychiatry; psychosis; recovery; schizophrenia; therapy
Case managers spend more time with clients with schizophrenia than any other professional group does in most clinical settings in the United States. Cognitive behavioral therapy (CBT) adapted for individuals with persistent psychotic symptoms, referred to as CBT-p, has proven to be a useful intervention when given by expert therapists in randomized clinical trials. It is currently unknown whether techniques derived from CBT-p could be safely and effectively delivered by case managers in community mental health agencies. Thirteen case managers at a community mental health center took part in a 5-day training course and had weekly supervision. In an open trial, 38 clients with schizophrenia had 12 meetings with their case managers during which high-yield cognitive behavioral techniques for psychosis (HYCBt-p) were used. The primary outcome measure was overall symptom burden as measured by the Comprehensive Psychopathological Rating Scale, which was independently administered at baseline and end of intervention. Secondary outcomes were dimensions of hallucinations and delusions, negative symptoms, depression, anxiety, social functioning, and self-rated recovery. Good and poor clinical outcomes were defined a priori as a 25% improvement or deterioration. t-Tests and Wilcoxon's signed-ranks tests showed significant improvements in all primary and secondary outcomes by the end of the intervention except for delusions, social functioning, and self-rated recovery. Cohen's d effect sizes were medium to large for overall symptoms (d = 1.60; 95% confidence interval [CI], -2.29 to 5.07), depression (d = 1.12; 95% CI, -0.35 to 1.73), and negative symptoms (d = 0.87; 95% CI, -0.02 to 1.62). There was a weak effect on dimensions of hallucinations but not delusions. Twenty-three (60.5%) of 38 patients had a good clinical result. One (2.6%) of 38 patients had a poor clinical result. No patients dropped out. This exploratory trial provides evidence supportive of the safety and the benefits of case managers being trained to provide HYCBt-p to their clients with persistent psychosis. The benefits reported here are particularly pertinent to the domains of overall symptom burden, depression, and negative symptoms and implementation of recovery-focused services.
Turkington D; Munetz M; Pelton J; Montesano V; Sivec H; Nausheen B; Kingdon D
Journal of Nervous and Mental Disease
2014
2014-01
Journal Article
<a href="http://doi.org/10.1097/nmd.0000000000000070" target="_blank" rel="noreferrer noopener">10.1097/nmd.0000000000000070</a>
The MATRICS consensus cognitive battery, part 1: Test selection, reliability, and validity
improve cognition; memory; performance; programs; Psychiatry; Rehabilitation; scale; schizophrenia; severe mental-illness; support
Objective: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific evaluation of measures. Method: The MATRICS Neurocognition Committee evaluated more than 90 tests in seven cognitive domains to identify the 36 most promising measures. A separate expert panel evaluated the degree to which each test met specific selection criteria. Twenty tests were selected as a beta battery. The beta battery was administered to 176 individuals with schizophrenia and readministered to 167 of them 4 weeks later so that the 20 tests could be compared directly. Results: The expert panel ratings are presented for the initially selected 36 tests. For the beta battery tests, data on test-retest reliability, practice effects, relationships to functional status, practicality, and tolerability are presented. Based on these data, 10 tests were selected to represent seven cognitive domains in the MATRICS Consensus Cognitive Battery. Conclusions: The structured consensus method was a feasible and fair mechanism for choosing candidate tests, and direct comparison of beta battery tests in a common sample allowed selection of a final consensus battery. The MATRICS Consensus Cognitive Battery is expected to be the standard tool for assessing cognitive change in clinical trials of cognition-enhancing drugs for schizophrenia. it may also aid evaluation of cognitive remediation strategies.
Nuechterlein K H; Green M F; Kern R S; Baade L E; Barch D M; Cohen J D; Essock S; Fenton W S; Frese F J; Gold J M; Goldberg T; Heaton R K; Keefe R S E; Kraemer H; Mesholam-Gately R; Seidman L J; Stover E; Weinberger D R; Young A S; Zalcman S; Marder S R
American Journal of Psychiatry
2008
2008-02
Journal Article
<a href="http://doi.org/10.1176/appi.ajp.2007.07010042" target="_blank" rel="noreferrer noopener">10.1176/appi.ajp.2007.07010042</a>
Use of the sequential intercept model as an approach to decriminalization of people with serious mental illness
courts; disorders; Environmental & Occupational; Health; Health Care Sciences & Services; health emergencies; incarceration; outcomes; police; psychiatric disabilities; Psychiatry; Public; schizophrenia; service
The Sequential Intercept Model provides a conceptual framework for communities to use when considering the interface between the criminal justice and mental health systems as they address concerns about criminalization of people with mental illness. The model envisions a series of points of interception at which an intervention can be made to prevent individuals from entering or penetrating deeper into the criminal justice system. Ideally, most people will be intercepted at early points, with decreasing numbers at each subsequent point. The interception points are law enforcement and emergency services; initial detention and initial hearings; jail, courts, forensic evaluations, and forensic commitments; reentry from jails, state prisons, and forensic hospitalization; and community corrections and community support. The model provides an organizing tool for a discussion of diversion and linkage alternatives and for systematically addressing criminalization. Using the model, a community can develop targeted strategies that evolve over time to increase diversion of people with mental illness from the criminal justice system and to link them with community treatment.
Munetz M R; Griffin P A
Psychiatric Services
2006
2006-04
Journal Article
<a href="http://doi.org/10.1176/appi.ps.57.4.544" target="_blank" rel="noreferrer noopener">10.1176/appi.ps.57.4.544</a>
Benefits from multiple perspectives: a consumer's view...Proceedings of Habits 2 Conference
Schizophrenia; Congresses and Conferences; Attitude to Disability; Consumer Attitudes; Habits
Frese FJ III
OTJR: Occupation, Participation & Health
2002
2002-12-16
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Ethnic and Age Disparities in Patients Taking Long-acting Injectable Atypical Antipsychotics.
antipsychotics; asian americans; duration of untreated psychosis; inpatient psychiatry; long-acting injections; psychopharmacology; racial disparities; schizophrenia
Introduction This study will determine whether different ethnicities and different age groups receive equal amounts of long-acting atypical antipsychotics in comparison to their oral equivalents. Methods Secondary analyses of data from the Los Angeles County Department of Health Services Electronic Health Record (total N=63,134 inpatient visits) were performed. Chi-squared statistics were used to compare ethnicity and age with the use of either risperidone injectable or paliperidone palmitate (r-LAIs) versus risperidone oral. Results Among the 63,134 total inpatient visits, there were 3,011 patient visits that included the use of an atypical antipsychotic. Of these 3,011 visits, 452 (15.0%) were on r-LAIs and 2,559 (85.0%) were on risperidone oral. No statistically significant disparities were identified with the use of r-LAIs as compared to oral risperidone amongst ethnic groups (chi-square = 0.88, df = 3, p = 0.831). However, there was a statistically significant difference with the use of r-LAIs as compared to oral Risperidone amongst age groups, favoring younger patients (chi-square = 13.46, df = 3, p \textless 0.004). Conclusion Our data indicate a lack of ethnic disparities in prescribing long-acting atypical antipsychotics and an increased percentage of younger patients being treated with atypical depot antipsychotics over their oral equivalents.
Soleman Mateen; Lam Nikki; Woo Benjamin K
Cureus
2017
2017-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.7759/cureus.1772" target="_blank" rel="noreferrer noopener">10.7759/cureus.1772</a>
Inducible Nitric Oxide Inhibitors Block NMDA Antagonist-Stimulated Motoric Behaviors and Medial Prefrontal Cortical Glutamate Efflux.
schizophrenia; ataxia; green tea; iNOS; microdialysis; nNOS; phencyclidine; stereotypy
Nitric oxide (NO) plays a critical role in the motoric and glutamate releasing action of N-methyl-D-aspartate (NMDA)-antagonist stimulants. Earlier studies utilized neuronal nitric oxide synthase inhibitors (nNOS) for studying the neurobehavioral effects of non-competitive NMDA-antagonist stimulants such as dizocilpine (MK-801) and phencyclidine (PCP). This study explores the role of the inducible nitric oxide synthase inhibitors (iNOS) aminoguanidine (AG) and (-)-epigallocatechin-3-gallate (EGCG) in NMDA-antagonist induced motoric behavior and prefrontal cortical glutamate e ffl ux. Adult male rats were administered a dose range of AG, EGCG, or vehicle prior to receiving NMDA antagonists MK-801, PCP, or a conventional psychostimulant (cocaine) and tested for motoric behavior in an open arena. Glutamate in the medial prefrontal cortex (mPFC) was measured using in vivo microdialysis after a combination of AG or EGCG prior to MK-801. Acute administration of AG or EGCG dose-dependently attenuated the locomotor and ataxic properties of MK-801 and PCP. Both AG and EGCG were unable to block the motoric effects of cocaine, indicating the acute pharmacologic action of AG and EGCG is specific to NMDA antagonism and not generalizable to all stimulant class drugs. AG and EGCG normalized MK-801-stimulated mPFC glutamate e ffl ux. These data demonstrate that AG and EGCG attenuates NMDA antagonist-stimulated motoric behavior and cortical glutamate e ffl ux. Our results suggest that EGCG-like polyphenol nutraceuticals (contained in "green tea" and chocolate) may be clinically useful in protecting against the adverse behavioral dissociative and cortical glutamate stimulating effects of NMDA antagonists. Medications that interfere with NMDA antagonists such as MK-801 and PCP have been proposed as treatments for schizophrenia.
Bergstrom Hadley C; Darvesh Altaf S; Berger S P
Frontiers in pharmacology
2015
1905-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3389/fphar.2015.00292" target="_blank" rel="noreferrer noopener">10.3389/fphar.2015.00292</a>
On the impact of being diagnosed with schizophrenia.
Adult; Humans; Male; Adaptation; Hospitalization; Schizophrenia; Stigma; Mental Health; Sick Role; *Mental Recall; Life Experiences; Antipsychotic Agents/adverse effects/therapeutic use; Delusions; Veterans/psychology; Vietnam Conflict; Psychological; Rehabilitation; Paranoid/*diagnosis/psychology/rehabilitation; Vocational/psychology; DIAGNOSIS of schizophrenia; FIRST person narrative; War; Military Personnel; Schizophrenia – Diagnosis
Frese Frederick J
Journal of mental health (Abingdon, England)
2010
2010-08
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.3109/09638237.2010.492419" target="_blank" rel="noreferrer noopener">10.3109/09638237.2010.492419</a>
Coming out of the shadows.
Humans; Male; Chronic Disease; Prognosis; Schizophrenia; Recurrence; Health Education; Narration; *Self Disclosure; Autobiography as Topic; Delusions/psychology; Hallucinations/psychology; Military Personnel/*psychology; Prejudice; Sick Role; Social Justice; Self Disclosure; Narratives; Psychiatric Patients; Recovery; Chronic; Paranoid/*diagnosis/rehabilitation; Rehabilitation; Vocational; Mental Disorders; Attitude to Disability; Correctional Facilities; Psychologists
Frese Fred
Health affairs (Project Hope)
2009
2009-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1377/hlthaff.28.3.880" target="_blank" rel="noreferrer noopener">10.1377/hlthaff.28.3.880</a>
Report on ISCTM Consensus Meeting on Clinical Assessment of Response to Treatment of Cognitive Impairment in Schizophrenia.
*Schizophrenic Psychology; Antipsychotic Agents/*therapeutic use; Cognition Disorders; Cognition Disorders/diagnosis/psychology/*therapy; cognitive assessment; Functional Assessment; Humans; Interviews; Neuropsychological Tests; neuropsychology; Nootropic Agents/*therapeutic use; Patient Selection; Psychiatric Rehabilitation/*methods; Research Instruments; Schizophrenia; Schizophrenia – Drug Therapy; Schizophrenia/diagnosis/*therapy; Severity of Illness Index; Surveys; treatment; United States Food and Drug Administration
If treatments for cognitive impairment are to be utilized successfully, clinicians must be able to determine whether they are effective and which patients should receive them. In order to develop consensus on these issues, the International Society for CNS Clinical Trials and Methodology (ISCTM) held a meeting of experts on March 20, 2014, in Washington, DC. Consensus was reached on several important issues. Cognitive impairment and functional disability were viewed as equally important treatment targets. The group supported the notion that sufficient data are not available to exclude patients from available treatments on the basis of age, severity of cognitive impairment, severity of positive symptoms, or the potential to benefit functionally from treatment. The group reached consensus that cognitive remediation is likely to provide substantial benefits in combination with procognitive medications, although a substantial minority believed that medications can be administered without nonpharmacological therapy. There was little consensus on the best methods for assessing cognitive change in clinical practice. Some participants supported the view that performance-based measures are essential for measurement of cognitive change; others pointed to their cost and time requirements as evidence of impracticality. Interview-based measures of cognitive and functional change were viewed as more practical, but lacking validity without informant involvement or frequent contact from clinicians. The lack of consensus on assessment methods was viewed as attributable to differences in experience and education among key stakeholders and significant gaps in available empirical data. Research on the reliability, validity, sensitivity, and practicality of competing methods will facilitate consensus.
Keefe Richard S E; Haig George M; Marder Stephen R; Harvey Philip D; Dunayevich Eduardo; Medalia Alice; Davidson Michael; Lombardo Ilise; Bowie Christopher R; Buchanan Robert W; Bugarski-Kirola Dragana; Carpenter William T; Csernansky John T; Dago Pedro L; Durand Dante M; Frese Frederick J; Goff Donald C; Gold James M; Hooker Christine I; Kopelowicz Alex; Loebel Antony; McGurk Susan R; Opler Lewis A; Pinkham Amy E; Stern Robert G
Schizophrenia bulletin
2016
2016-01
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1093/schbul/sbv111" target="_blank" rel="noreferrer noopener">10.1093/schbul/sbv111</a>
Severe rhabdomyolysis after doxylamine overdose.
Adult; Attempted; Bicarbonates/therapeutic use; Creatine Kinase/blood; Doxylamine/*analogs & derivatives/blood/poisoning; Drug Overdose/blood/complications; Epilepsy; Histamine H1 Antagonists/blood/*poisoning; Humans; Intratracheal; Intubation; Male; Paranoid/complications; Rhabdomyolysis/*diagnosis/etiology/therapy; Schizophrenia; Sodium Bicarbonate; Sodium/therapeutic use; Suicide; Tonic-Clonic/etiology
Clinicians should be aware of the complications of rhabdomyolysis in patients who ingest doxylamine succinate and other over-the-counter antihistamines. The easy availability of these substances increases the potential not only for intentional overdose by adults but also for inadvertent ingestion by children. Prompt intervention and careful assessment of renal function, urinary output, and serum creatine kinase levels may represent the difference between an uncomplicated course and acute renal failure.
Soto L F; Miller C H; Ognibere A J
Postgraduate medicine
1993
1993-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1080/00325481.1993.11701728" target="_blank" rel="noreferrer noopener">10.1080/00325481.1993.11701728</a>
Cognitive behavioral therapy for psychosis in clinical practice.
Adaptation; Affect; Cognitive Behavioral Therapy/*methods; Cognitive Therapy – Methods; Coping; Delusions; Descriptive Statistics; Effect Size; Funding Source; Hallucinations; Hallucinations/psychology/therapy; Human; Humans; Meta Analysis; Professional-Patient Relations; Psychological; Psychotic Disorders – Therapy; Psychotic Disorders/psychology/*therapy; Schizophrenia; Schizophrenia/therapy; Schizophrenic Psychology; Secondary Prevention; Systematic Review; Treatment Outcome; United Kingdom; United States
Across two continents, Cognitive-Behavioral Therapy for Psychosis (CBT-P) has been endorsed as an adjunctive treatment for individuals who experience persistent positive symptoms of schizophrenia. The moderate effect sizes reported in early studies and reviews were followed by better controlled studies indicating more limited effect sizes. This article provides a review of the literature that addresses the effectiveness of CBT-P, including particular areas of emphasis and practice elements associated with this approach. In addition, because the majority of research on CBT-P has been performed in the United Kingdom, implications for implementation and sustainability of this practice in the United States are presented.
Sivec Harry J; Montesano Vicki L
Psychotherapy (Chicago, Ill.)
2012
2012-06
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1037/a0028256" target="_blank" rel="noreferrer noopener">10.1037/a0028256</a>
The niacin response biomarker as a schizophrenia endophenotype: A status update.
Biomarker; Endophenotype; Niacin; Schizophrenia; Vasodilation
Increasingly, it is recognized that the behavioral syndrome of schizophrenia is not a unitary disease with a single underlying cause. Rather, it may have several possible etiologies, and its symptoms may arise from multiple causes. Such heterogeneity could account for some of the difficulties in elucidating its genetics, and may also explain clinical observations of variable medication response in schizophrenia. The ability to categorize schizophrenia using objectively recognizable, physiologically-based subtypes promises to make our understanding of schizophrenia more comprehensive and could provide some clues for more personalized treatment. This paper will review the extent to which an abnormally blunted skin flush response to niacin satisfies the criteria for a schizophrenia endophenotype.
Messamore Erik
Prostaglandins, leukotrienes, and essential fatty acids
2018
2018-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.plefa.2017.06.014" target="_blank" rel="noreferrer noopener">10.1016/j.plefa.2017.06.014</a>
A rapid UPLC-MS/MS assay for eicosanoids in human plasma: Application to evaluate niacin responsivity.
Arachidonic acid; Eicosanoids; Mass spectrometry; Niacin; Plasma; Prostanoids; Schizophrenia; Ultra performance liquid chromatography; UPLC-MS/MS
A rapid and sensitive method using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed to simultaneously quantify hydroxyeicosatetraenoic (HETE), dihydroxyeicosatrienoic (DiHETrE), epoxyeicosatrienoic acid (EET), and prostaglandin metabolites of arachidonic acid in human plasma. Sample preparation consisted of solid phase extraction with Oasis HLB (30mg) cartridges for all metabolites. Separation of HETEs, EETs, and DiHETrEs was achieved on an Acquity UPLC BEH C18, 1.7microm (100x2.1mm) reversed-phase column (Waters Corp, Millford, MA) with negative electrospray ionization mass spectrometric detection. A second injection of the same extracted sample allowed for separation and assessment of prostaglandin metabolites under optimized UPLC-MS/MS conditions. Additionally, the endogenous levels of these metabolites in five different matrices were determined in order to select the optimal matrix for assay development. Human serum albumin was shown to have the least amount of endogenous metabolites, a recovery efficiency of 79-100% and a matrix effect of 71 - 100%. Linear calibration curves ranging from 0.416 to 66.67ng/ml were validated. Inter-assay and intra-assay variance was less than 15% at most concentrations. This method was successfully applied to quantify metabolite levels in plasma samples of healthy control subjects receiving niacin administration to evaluate the association between niacin administration and eicosanoid plasma level response.
Miller Tricia M; Poloyac Samuel M; Anderson Kacey B; Waddell Brooke L; Messamore Erik; Yao Jeffrey K
Prostaglandins, leukotrienes, and essential fatty acids
2018
2018-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.plefa.2017.01.003" target="_blank" rel="noreferrer noopener">10.1016/j.plefa.2017.01.003</a>
Exploring the Role of YouTube in Disseminating Psychoeducation.
*Models; China – Ethnology; China/ethnology; Communication; Educational; Human; Humans; Mental health; Mental Health – Education; Mental Health/*education; Models; Schizophrenia; Social media; Social Media – Utilization; Social Media/*statistics & numerical data; Social Stigma; Stigma; United States; Video Recording/*trends; Videorecording – Trends; Young Adult
OBJECTIVE: Social media can bridge the gap between health care and ethnic minorities over cultural barriers. This study explores the role of YouTube in delivering schizophrenia education to individuals in the USA who are also fluent in Chinese. METHODS: Three psychoeducational YouTube videos related to schizophrenia were uploaded. Data were collected for a 12-month period, and results were analyzed using descriptive statistics. RESULTS: The videos recorded 4935 views with a total viewing time of 35,614 min. The first-episode psychosis video had the most number of views and shares, and the longest total watch time and average view duration. The targeted age group (\textless 34 years old) comprised about half of the total views and had a 14.4% longer average view duration compared to the overall average. CONCLUSION: YouTube is a useful tool that delivers schizophrenia education to Chinese-speaking individuals in the USA. It may also help alleviate the negative stigma regarding schizophrenia and other mental health issues.
Lam Nikki Hei Tong; Tsiang John Ta-Hsiang; Woo Benjamin K P
Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
2017
2017-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1007/s40596-017-0835-9" target="_blank" rel="noreferrer noopener">10.1007/s40596-017-0835-9</a>
Cognitive Behavioral Therapy for Psychosis (CBT-p) Delivered in a Community Mental Health Setting: A Case Comparison of Clients Receiving CBT Informed Strategies by Case Managers Prior to Therapy.
*Case Managers; *CBT-p; *Cognitive behavioral techniques for psychosis; *Cognitive behavioral therapy for psychosis; *Community Mental Health Services; *Continuum of care; *Schizophrenia; Adult; Case Management; Case-Control Studies; Cognitive Behavioral Therapy/*methods; Cognitive Therapy – Methods; Community Mental Health Services; Comparative Studies; Continuity of Patient Care; Evidence-Based; Exploratory Research; Female; Human; Humans; Male; Middle Aged; Outcome Assessment; Professional Practice; Program Implementation – Methods; Psychotic Disorders – Therapy; Psychotic Disorders/*therapy; Schizophrenia; Surveys and Questionnaires
This exploratory case comparison examines the influence of case management activities on engagement and progress in psychotherapy for clients with schizophrenia. Six clients were recruited to participate in ten sessions of Cognitive Behavioral Therapy for psychosis (CBT-p). Three clients who had received Cognitive Behavioral techniques for psychosis (CBt-p, a low-intensity case management intervention) prior to receiving therapy were selected from referrals. A comparison group of three clients who had received standard case management services was selected from referrals. Cases within and across groups were compared on outcome measures and observations from case review were offered to inform future research. Delivering CBT-p services on a continuum from low- to high-intensity is discussed.
Sivec Harry J; Montesano Vicki L; Skubby David; Knepp Kristen A; Munetz Mark R
Community mental health journal
2017
2017-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1007/s10597-015-9930-0" target="_blank" rel="noreferrer noopener">10.1007/s10597-015-9930-0</a>