Browse Items · NEOMED Bibliography Database

Retrograde axonal tracing with fluorescent markers.

The growth of fluorescence imaging technology and the development of sensitive fluorescent retrograde tracers has provided many new approaches for analyzing neuronal circuits. Fluorescent markers provide unparalleled opportunity for combining axonal…

Tags: *Fluorescent Dyes, 2008, Animals, Axons/*ultrastructure, Current protocols in neuroscience, Department of Anatomy & Neurobiology, Fluorescent Antibody Technique/*methods, Humans, NEOMED College of Medicine, Neural Pathways/*anatomy & histology, Schofield Brett R

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.

Axonal transport defects are an early pathology occurring within the retinofugal projection of the DBA/2J mouse model of glaucoma. Retinal ganglion cell (RGC) axons and terminals are detectable after transport is affected, yet little is known about…

Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z

Perineuronal nets in subcortical auditory nuclei of four rodent species with differing hearing ranges.

Perineuronal nets (PNs) are aggregates of extracellular matrix molecules that surround some neurons in the brain. While PNs occur widely across many cortical areas, subcortical PNs are especially associated with motor and auditory systems. The…

Bilateral projections to the thalamus from individual neurons in the inferior colliculus.

The medial geniculate body (MG) receives a large input from the ipsilateral inferior colliculus (IC) and a smaller but substantial input from the contralateral IC. Both crossed and uncrossed inputs comprise a large percentage of glutamatergic cells…

Tags: 2019, Beebe Nichole L, collateral, Department of Anatomy & Neurobiology, GABA, inferior colliculus, medial geniculate body, Mellott Jeffrey G, NEOMED College of Medicine, RRID:AB2278725, RRID:AB260754, Schofield Brett R, synchronization, The Journal of comparative neurology

Anterograde Tract Tracing for Assaying Axonopathy and Transport Deficits in Glaucoma.

Whether to stage degeneration or investigate early pathology in glaucoma, examination of axonal structure and function is essential. There are a wide variety of methods available to investigators using animal models of glaucoma, with varying…

GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.

The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports…

Cells in auditory cortex that project to the cochlear nucleus in guinea pigs.

Fluorescent retrograde tracers were used to identify the cells in auditory cortex that project directly to the cochlear nucleus (CN). Following injection of a tracer into the CN, cells were labeled bilaterally in primary auditory cortex and the…

Tags: 2006, Animals, Auditory Cortex/*cytology, Cochlear Nucleus/*cytology, Coomes Diana L, Department of Anatomy & Neurobiology, Fluorescent Dyes, Guinea Pigs, Journal of the Association for Research in Otolaryngology : JARO, NEOMED College of Medicine, Pyramidal Cells/*cytology, Schofield Brett R, Schofield Ryan M

Projections from auditory cortex to cholinergic cells in the midbrain tegmentum of guinea pigs.

Anterograde and retrograde tracing techniques were used to characterize projections from the auditory cortex to the pedunculopontine and laterodorsal tegmental nuclei (PPT and LDT, respectively) in the midbrain tegmentum in guinea pigs. For…

Pathways from auditory cortex to the cochlear nucleus in guinea pigs.

The inferior colliculus (IC) and superior olivary complex (SOC) are important sources of descending pathways to the cochlear nucleus. The IC and SOC are also targets of direct projections from the auditory cortex but it is not known if cortical axons…

Projections from auditory cortex contact ascending pathways that originate in the superior olive and inferior colliculus.

The superior olivary complex (SOC) and inferior colliculus (IC) are targets of cortical projections as well as sources of major ascending auditory pathways. This study examines whether the cortical projections contact cells in the SOC or IC that…

Tags: 2007, Animals, Auditory Cortex/*cytology, Auditory Pathways/*cytology, Department of Anatomy & Neurobiology, Fluorescence, Guinea Pigs, Hearing research, Inferior Colliculi/*cytology, Microscopy, NEOMED College of Medicine, Olivary Nucleus/*cytology, Peterson Diana Coomes, Schofield Brett R, Staining and Labeling/methods

Cholinergic cells of the pontomesencephalic tegmentum: connections with auditory structures from cochlear nucleus to cortex.

Acetylcholine (ACh) is a neuromodulator that is likely to play a role in plasticity as well as other phenomena at many sites in the auditory system. The auditory cortex receives cholinergic innervation from the basal forebrain, whereas the cochlea…

Auditory cortical axons contact commissural cells throughout the guinea pig inferior colliculus.

Projections from auditory cortex (AC) affect how cells in both inferior colliculi (IC) respond to acoustic stimuli. The large projection from the AC to the ipsilateral IC is usually credited with the effects in the ipsilateral IC. The circuitry…

Tags: 2013, AC, Animals, auditory cortex, Auditory Cortex/*physiology, Auditory Pathways/cytology, Axons/metabolism/*pathology, Brain Mapping, cortical layers, Department of Anatomy & Neurobiology, Fast Blue, FB, FD, Female, FG, Fluor0Ruby, fluorescein dextran, Fluorescence, FluoroGold, FR, G-, G+, GAD, GAD-immunonegative, GAD-immunopositive, GAD-neg, gamma-Aminobutyric Acid/metabolism, GB, Glutamate Decarboxylase/metabolism, glutamic acid decarboxylase, green RetroBeads, Guinea Pigs, Hearing research, I-VI, IC, IC central nucleus, IC dorsal cortex, IC lateral cortex, IC rostral cortex, ICc, ICd, IClc, ICrc, Inferior Colliculi/pathology/*physiology, inferior colliculus, Male, Mesencephalon/pathology, Microscopy, Nakamoto Kyle T, NEOMED College of Medicine, ps, pseudosylvian sulcus, rhinal sulcus, rs, Schofield Brett R, Sowick Colleen S, white matter, wm

Subtypes of GABAergic cells in the inferior colliculus.

The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to…

Tags: 2018, Auditory system, Beebe Nichole L, Cell type, Department of Anatomy & Neurobiology, GABA, Hearing research, inhibition, NEOMED College of Medicine, perineuronal net, Schofield Brett R

Extracellular Molecular Markers and Soma Size of Inhibitory Neurons: Evidence for Four Subtypes of GABAergic Cells in the Inferior Colliculus.

UNLABELLED: Inhibition plays an important role in shaping responses to stimuli throughout the CNS, including in the inferior colliculus (IC), a major hub in both ascending and descending auditory pathways. Subdividing GABAergic cells has furthered…

Circuitry underlying spectrotemporal integration in the auditory midbrain.

Combination sensitivity in central auditory neurons is a form of spectrotemporal integration in which excitatory responses to sounds at one frequency are facilitated by sounds within a distinctly different frequency band. Combination-sensitive…

Tags: 2011, Acoustic Stimulation/*methods, Animals, Auditory Pathways/*physiology, Chiroptera, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Female, Male, Mesencephalon/*physiology, NEOMED College of Medicine, Nerve Net/*physiology, Schofield Brett R, The Journal of neuroscience : the official journal of the Society for Neuroscience, Time Factors, Wenstrup Jeffrey J, Yavuzoglu Asuman

Cholinergic and non-cholinergic projections from the pedunculopontine and laterodorsal tegmental nuclei to the medial geniculate body in Guinea pigs.

The midbrain tegmentum is the source of cholinergic innervation of the thalamus and has been associated with arousal and control of the sleep/wake cycle. In general, the innervation arises bilaterally from the pedunculopontine tegmental nucleus (PPT)…

Tags: 2010, Acetylcholine, Arousal, Auditory, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, GABA, glutamate, Motts Susan D, NEOMED College of Medicine, Schofield Brett R, sleep, thalamus

Ultrastructural examination of the corticocollicular pathway in the guinea pig: a study using electron microscopy, neural tracers, and GABA immunocytochemistry.

Projections from auditory cortex (AC) can alter the responses of cells in the inferior colliculus (IC) to sounds. Most IC cells show excitation and inhibition after stimulation of the AC. AC axons release glutamate and excite their targets, so…

Tags: 2013, auditory cortex, bouton classification, corticofugal pathways, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, inferior colliculi, Killius Jeanette, Mellott Jeffrey G, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, Sowick Colleen S, Storey-Workley Megan E, synaptic targets, ultrastructural variations

Perineuronal nets and GABAergic cells in the inferior colliculus of guinea pigs.

Perineuronal nets (PNs) are aggregates of extracellular matrix that have been associated with neuronal plasticity, critical periods, fast-spiking cells and protection from oxidative stress. Although PNs have been reported in the auditory system in…

Tags: 2014, Auditory, Department of Anatomy & Neurobiology, Extracellular Matrix, Foster Nichole L, Frontiers in neuroanatomy, GABA, inhibition, Mellott Jeffrey G, midbrain, NEOMED College of Medicine, plasticity, Schofield Brett R

Projections from the dorsal and ventral cochlear nuclei to the medial geniculate body.

Direct projections from the cochlear nucleus (CN) to the medial geniculate body (MG) mediate a high-speed transfer of acoustic information to the auditory thalamus. Anderson etal. (2006) used anterograde tracers to label the projection from the…

Tags: 2014, collateral projections, Department of Anatomy & Neurobiology, fear conditioning, Foster Nichole L, Frontiers in neuroanatomy, lemniscal pathway, magnocellular pathway, Mellott Jeffrey G, Motts Susan D, multimodal processing, multipolar cells, NEOMED College of Medicine, Schofield Brett R, T-stellate, thalamus

Distribution of GABAergic cells in the inferior colliculus that project to the thalamus.

A GABAergic component has been identified in the projection from the inferior colliculus (IC) to the medial geniculate body (MG) in cats and rats. We sought to determine if this GABAergic pathway exists in guinea pig, a species widely used in…

Tags: 2014, Auditory system, Department of Anatomy & Neurobiology, Foster Nichole L, Frontiers in neuroanatomy, GAD, inhibition, medial geniculate, Mellott Jeffrey G, Motts Susan D, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, tectothalamic

Subcollicular projections to the auditory thalamus and collateral projections to the inferior colliculus.

Experiments in several species have identified direct projections to the medial geniculate nucleus (MG) from cells in subcollicular auditory nuclei. Moreover, many cochlear nucleus cells that project to the MG send collateral projections to the…

Tags: 2014, binaural, brain evolution, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, lateral lemniscus, medial geniculate nucleus, Mellott Jeffrey G, Motts Susan D, NEOMED College of Medicine, paralemniscal area, parallel pathways, reticular formation, Schofield Brett R, superior olive

Ultrastructural characterization of GABAergic and excitatory synapses in the inferior colliculus.

In the inferior colliculus (IC) cells integrate inhibitory input from the brainstem and excitatory input from both the brainstem and auditory cortex. In order to understand how these inputs are integrated by IC cells identification of their synaptic…

Tags: 2014, Auditory, circuit, Department of Anatomy & Neurobiology, Frontiers in neuroanatomy, gamma-aminobutyric acid, inhibition, Killius Jeanette, Mellott Jeffrey G, Nakamoto Kyle T, NEOMED College of Medicine, Schofield Brett R, Sowick Colleen S, Storey-Workley Megan E, ultrastructure

Excitatory and inhibitory projections in parallel pathways from the inferior colliculus to the auditory thalamus.

Individual subdivisions of the medial geniculate body (MG) receive a majority of their ascending inputs from 1 or 2 subdivisions of the inferior colliculus (IC). This establishes parallel pathways that provide a model for understanding auditory…

Tags: 2014, Auditory system, Department of Anatomy & Neurobiology, Foster Nichole L, Frontiers in neuroanatomy, GABA, GAD, lemniscal, medial geniculate, Mellott Jeffrey G, NEOMED College of Medicine, non-lemniscal, Ohl Andrew P, Schofield Brett R, tectothalamic

Descending projections from auditory cortex to excitatory and inhibitory cells in the nucleus of the brachium of the inferior colliculus.

Descending projections from the auditory cortex (AC) terminate in subcortical auditory centers from the medial geniculate nucleus (MG) to the cochlear nucleus, allowing the AC to modulate the processing of acoustic information at many levels of the…

Tags: 2014, ascending, Bickford Martha E, corticofugal, Department of Anatomy & Neurobiology, Frontiers in systems neuroscience, GABA, medial geniculate nucleus, Mellott Jeffrey G, modulation, NEOMED College of Medicine, Schofield Brett R

Bilateral projections to the thalamus from individual neurons in the inferior colliculus.

The medial geniculate body (MG) receives a large input from the ipsilateral inferior colliculus (IC) and a smaller but substantial input from the contralateral IC. Both crossed and uncrossed inputs comprise a large percentage of glutamatergic cells…

Tags: 2019, Beebe Nichole L, collateral, Department of Anatomy & Neurobiology, GABA, inferior colliculus, medial geniculate body, Mellott Jeffrey G, NEOMED College of Medicine, RRID:AB2278725, RRID:AB260754, Schofield Brett R, synchronization, The Journal of comparative neurology

Subtypes of GABAergic cells in the inferior colliculus

The inferior colliculus occupies a central position in ascending and descending auditory pathways. A substantial proportion of its neurons are GABAergic, and these neurons contribute to intracollicular circuits as well as to extrinsic projections to…

Tags: 2019, Auditory system, Beebe Nichole L, Cell type, Department of Anatomy & Neurobiology, GABA, Hearing research, inhibition, June 2019 Update, NEOMED College of Medicine, perineuronal net, Schofield Brett R

A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice

Located in the midbrain, the inferior colliculus (IC) is the hub of the central auditory system. Although the IC plays important roles in speech processing, sound localization, and other auditory computations, the organization of the IC…

Generation of a ChAT(Cre) mouse line without the early onset hearing loss typical of the C57BL/6J strain.

The development of knockin mice with Cre recombinase expressed under the control of the promoter for choline acetyltransferase (ChAT) has allowed experimental manipulation of cholinergic circuits. However, currently available ChAT(Cre) mouse lines…

Tags: 2020, Acetylcholine, Age-related hearing loss, Beebe Nichole L, Choline acetyltransferase, Cox Brandon C, Department of Anatomy & Neurobiology, Galazyuk Alexander V, Hearing research, Kristaponyte Inga, NEOMED College of Medicine, Normal hearing, Presbycusis, Schofield Brett R, Sowick Colleen S, Transgenic mouse, Vetter Douglas E

Perineuronal nets and subtypes of GABAergic cells differentiate auditory and multisensory nuclei in the intercollicular area of the midbrain.

The intercollicular region, which lies between the inferior and superior colliculi in the midbrain, contains neurons that respond to auditory, visual, and somatosensory stimuli. Golgi studies have been used to parse this region into three distinct…

Tags: 2020, ab_10807945, ab_141607, ab_2278725, ab_2336066, ab_2336132, ab_2336874, ab_2336875, ab_2336881, ab_2534012, ab_2535710, ab_2665454, ab_2735091, ascending projections, Beebe Nichole L, Department of Anatomy & Neurobiology, descending projections, dorsal column nuclei, efferent connections, external nucleus, extracellular-matrix, Guinea Pigs, inferior colliculus, intercollicular tegmentum, journalArticle, June 2020 Update II, lateral lemniscus, medial geniculate-body, NEOMED College of Medicine, Noftz William A, nucleus of the brachium of the inferior colliculus, rostral pole of the inferior colliculus, rrid, RRID: AB_10807945, RRID: AB_141607, RRID: AB_2278725, RRID: AB_2336066, RRID: AB_2336132, RRID: AB_2336874, RRID: AB_2336875, RRID: AB_2336881, RRID: AB_2534012, RRID: AB_2535710, RRID: AB_2665454, RRID: AB_2735091, RRID: SCR_001775, Schofield Brett R, scr_001775, superior colliculus, The Journal of comparative neurology, VGLUT2

Neuropeptide Y expression defines a novel class of GABAergic projection neuron in the inferior colliculus.

Located in the midbrain, the inferior colliculus (IC) integrates information from numerous auditory nuclei and is an important hub for sound processing. Despite its importance, little is known about the molecular identity and functional roles of…

Tags: 2020, Anair Justin D, Beebe Nichole L, Department of Anatomy & Neurobiology, journalArticle, June 2020 Update II, Mirjalili Pooyan, NEOMED College of Medicine, Roberts Michael T, Schofield Brett R, Silveira Marina A, The Journal of neuroscience : the official journal of the Society for Neuroscience

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