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<a href="http://doi.org/10.1038/s41590-020-0750-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/s41590-020-0750-1</a>
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1529-2916 1529-2908
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Update Year & Number
August 2020 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
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Title
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IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
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Nature Immunology
Date
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2020
2020-08-10
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Zhou H; Wang H; Yu M; Schugar RC; Qian W; Tang F; Liu W; Yang H; McDowell RE; Zhao J; Gao J; Dongre A; Carman JA; Yin M; Drazba JA; Dent R; Hine C; Chen Y; Smith JD; Fox PL; Brown JM; Li X
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Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of IRAK2 Myddosome to mitochondria outer membranes via recognition by TOM20, followed by TIMM50-guided translocation of IRAK2 into mitochondria inner membranes, to suppress oxidative phosphorylation and fatty acid oxidation, thereby attenuating energy expenditure. Adipocyte-specific MyD88 or IRAK2 deficiency reduced high-fat-diet-induced weight gain, increased energy expenditure and ameliorated insulin resistance, associated with a smaller adipocyte size and increased cristae formation. IRAK2 kinase inactivation also reduced high-fat diet-induced metabolic diseases. Mechanistically, IRAK2 suppressed respiratory super-complex formation via interaction with PHB1 and OPA1 upon stimulation of IL-1. Taken together, our results suggest that the IRAK2 Myddosome functions as a critical link between inflammation and metabolism, representing a novel therapeutic target for patients with obesity.
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<a href="http://doi.org/10.1038/s41590-020-0750-1" target="_blank" rel="noreferrer noopener">10.1038/s41590-020-0750-1</a>
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journalArticle
2020
August 2020 List
Brown JM
Carman JA
Chen Y
Dent R
Department of Integrative Medical Sciences
Dongre A
Drazba JA
Fox PL
Gao J
Hine C
journalArticle
Li X
Liu W
McDowell RE
Nature Immunology
NEOMED College of Medicine
Qian W
Schugar RC
Smith JD
Tang F
Wang H
Yang H
Yin M
Yu M
Zhao J
Zhou H