1
40
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Text
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<a href="http://doi.org/10.1007/s00240-020-01183-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00240-020-01183-w</a>
ISSN
2194-7236 2194-7228
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Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pediatrics; Department of Anatomy & Neurobiology
Affiliated Hospital
Akron Children's Hospital
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Bone mineral density in adolescent urinary stone formers: is sex important?
Publisher
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Urolithiasis
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03-31
Subject
The topic of the resource
Bone; children; disease; fracture; health; inflammation; kidney-stones; nephrolithiasis; osteoporosis; Pediatrics; risk; Sex; Urolithiasis; Urolithiasis
Creator
An entity primarily responsible for making the resource
Kusumi Kirsten; Schwaderer Andrew L; Clark Curtis; Budge Kevin; Hussein Nazar; Raina Rupesh; Denburg Michelle; Safadi Fayez F
Description
An account of the resource
Urinary stone disease (USD) is affecting a greater number of children and low bone mineral density (BMD) and increased skeletal fractures have been demonstrated in stone patients; however, the mechanism(s) driving bone disease remain unclear. This pilot study was undertaken to assess an adolescent kidney stone cohort's BMD and evaluate for an inverse correlation between BMD and urine concentration of lithogenic minerals and/or inflammatory levels. Prospective case-control study was carried out at a large pediatric center. 15 participants with USD (12-18 years of age, 8 female) were matched by age, sex, and body mass index to 15 controls. Lumbar and total body BMD z-score did not differ between groups. When stone formers were separated by sex, there was a significant difference between male stone formers vs. controls total body BMD z-score (Fig. 1). BMD z-score did not significantly correlate with urine calcium, oxalate, citrate or magnesium. Higher urine IL-13 did significantly correlate with higher total body BMD z-score (r = 0.677, p = 0.018). Total body BMD z-score did significantly correlate with body mass index (BMI) as expected for the control group (r = 0.6321, p = 0.0133). However, this relationship was not present in the USD group (r = - 0.1629, p = 0.5619). This is a small but hypothesis-generating study which demonstrates novel evidence of male-specific low BMD in adolescent stone formers. Furthermore, we demonstrated a positive association between urine
Identifier
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<a href="http://doi.org/10.1007/s00240-020-01183-w" target="_blank" rel="noreferrer noopener">10.1007/s00240-020-01183-w</a>
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journalArticle
2020
Akron Children's Hospital
Bone
Budge Kevin
Children
Clark Curtis
Denburg Michelle
Department of Anatomy & Neurobiology
Department of Pediatrics
Disease
Fracture
Health
Hussein Nazar
Inflammation
Journal Article
journalArticle
June 2020 Update I
kidney-stones
Kusumi Kirsten
NEOMED College of Medicine
nephrolithiasis
Osteoporosis
Pediatrics
Raina Rupesh
Risk
Safadi Fayez F
Schwaderer Andrew L
sex
urolithiasis
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fped.2019.00032" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fped.2019.00032</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
32-32
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Comparison of Risk Factors for Pediatric Kidney Stone Formation: The Effects of Sex.
Publisher
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Frontiers in pediatrics
Date
A point or period of time associated with an event in the lifecycle of the resource
2019
2019
Subject
The topic of the resource
pediatrics; age; sex; kidney stones; urolithiasis
Creator
An entity primarily responsible for making the resource
Schwaderer Andrew L; Raina Rupesh; Khare Anshika; Safadi Fayez; Moe Sharon M; Kusumi Kirsten
Description
An account of the resource
Background: Urinary stones are affecting more children, and pediatric stone formers have unique pathophysiology compared to adults. While adult stone formers are most frequently male, children have an age dependent sex prevalence. Under 10 years, a majority of stone formers are boys; adolescent stone formers are mostly female. Previous adult studies have shown that stone composition is influenced by the sex and age of the stone former. Thus, we hypothesize that female and male stone forming children will also have sex and age specific stone phenotypes. Methods: Retrospective chart review of a large pediatric center's stone forming children 6/1/2009 to 6/1/2016. Patients were identified by ICD 9 codes: N20, N20.1, and N20.9. Charts were reviewed for radiographic evidence of stones or documented visualized stone passage. Results: One hundred and thirty six subjects: 54 males and 82 females. Females were older, median age 14 years [interquartile range (IQR): 11, 15] vs. males' median age 12 years (IQR: 11, 14) (p < 0.01). Females had lower height z-scores, median 0.2 (IQR: -0.8, 0.8) vs. males' median 0.8 (IQR: -0.2, 1.8) (p < 0.01). Presenting symptoms were similar except flank pain affecting 39% of females vs. 22% of males (p = 0.04). Leukocyte esterase was positive in more females than males (33 vs. 4%) (p < 0.001). Males had a higher BUN/Cr ratio, mean +/- standard deviation of 19.8 +/- 6.3 vs. 16.6 +/- 6.5 in females (p = 0.01). Glomerular hyperfiltration was present in 9% of patients while 35% of patients had estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m(2). Treatment strategies and clinical course were similar except females were told to increase dietary citrate more frequently than males (21 vs. 4%) (p < 0.01). Conclusion: We have provided a novel analysis and demonstrated that low height z-score and pyuria are more common in female stone formers. We have also shown that 9% of pediatric stone formers have labs consistent with hyperfiltration. Whether high protein intake and/or chronic dehydration are associated with hyperfiltration and long-term renal function in children with kidney stones will be an area for future research.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fped.2019.00032" target="_blank" rel="noreferrer noopener">10.3389/fped.2019.00032</a>
2019
Age
Department of Internal Medicine
Frontiers in pediatrics
Khare Anshika
KIDNEY STONES
Kusumi Kirsten
Moe Sharon M
NEOMED College of Medicine
Pediatrics
Raina Rupesh
Safadi Fayez
Schwaderer Andrew L
sex
urolithiasis