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Text
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URL Address
<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/srep43789</a>
Pages
43789–43789
Volume
7
Dublin Core
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Title
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A wogonin-rich-fraction of Scutellaria baicalensis root extract exerts chondroprotective effects by suppressing IL-1beta-induced activation of AP-1 in human OA chondrocytes.
Publisher
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Scientific reports
Date
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2017
2017-03
Subject
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Cells; Chemical Fractionation/methods; Chondrocytes/*drug effects/metabolism; Cultured; Cyclooxygenase 2/genetics/metabolism; Flavanones/*pharmacology; Gene Expression Regulation/drug effects; Humans; Interleukin-1beta/pharmacology; Interleukin-6/genetics/metabolism; Osteoarthritis/pathology; Plant Extracts/*pharmacology; Plant Roots/*chemistry; Protective Agents/pharmacology; Reactive Oxygen Species/metabolism; Scutellaria baicalensis/*chemistry; Transcription Factor AP-1/genetics/*metabolism
Creator
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Khan Nazir M; Haseeb Abdul; Ansari Mohammad Y; Haqqi Tariq M
Description
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Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation and sustained oxidative stress. The root extract of Scutellaria baicalensis (SBE) has been used for the treatment of inflammatory and other diseases. Here, we performed activity-guided HPLC-fractionation of SBE, identified the active ingredient(s) and investigated its chondroprotective potential. We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MMP-9,
Identifier
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<a href="http://doi.org/10.1038/srep43789" target="_blank" rel="noreferrer noopener">10.1038/srep43789</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Ansari Mohammad Y
Cells
Chemical Fractionation/methods
Chondrocytes/*drug effects/metabolism
Cultured
Cyclooxygenase 2/genetics/metabolism
Department of Anatomy & Neurobiology
Flavanones/*pharmacology
Gene Expression Regulation/drug effects
Haqqi Tariq M
Haseeb Abdul
Humans
Interleukin-1beta/pharmacology
Interleukin-6/genetics/metabolism
Khan Nazir M
NEOMED College of Medicine
Osteoarthritis/pathology
Plant Extracts/*pharmacology
Plant Roots/*chemistry
Protective Agents/pharmacology
Reactive Oxygen Species/metabolism
Scientific reports
Scutellaria baicalensis/*chemistry
Transcription Factor AP-1/genetics/*metabolism